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GNF-4877

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS8400360

GNF-4877 is a potent inhibitor of Dyrk1a (IC50 = 6nM) and GSK-3beta (IC50 = 16nM), that promotes pancreatic beta cell proliferation in rodent and human primary islets. More details

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Product Documentation
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Sample Manual Insert View PDF
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Testing Data View PDF
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Certificate of Analysis (COA) View PDF
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QC Report View PDF
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Material Safety Data Sheet View PDF
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Technical Datasheet View PDF
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Protocol View PDF

Product Overview

Product Name
GNF-4877, Biochemical
Full Product Name
GNF-4877
Product Gene Name
GNF-4877 biochemical
Product Synonym Names
GNF4877, (R)-1-(3-(3-Amino-6-(2-fluoro-5-isopropoxyphenyl)pyrazine-2-carboxamido)pyridin-4-yl)piperidine-3-carboxylic acid
Form/Format
Pale yellow to dark orange solid
Purity/Purification
>=98%
Specificity
A potent DYRK1A and GSK3beta inhibitor
Preparation and Storage
Store at -20 degree C
Do not take internally. Wear gloves and mask when handling the product! Avoid contact by all modes of exposure.
Shipping: Gel Pack
Shelf Life: Est.~36 months
Country of Origin: USA
Molecular Weight
494.52
Solubilities
~2mg/ml DMSO
Molecular Formula
C??H??FN?O?
InChi
InChI=1S/C25H27FN6O4/c1-14(2)36-16-5-6-18(26)17(10-16)19-12-29-23(27)22(30-19)24(33)31-20-11-28-8-7-21(20)32-9-3-4-15(13-32)25(34)35/h5-8; 10-12; 14-15H; 3-4; 9; 13H2; 1-2H3; (H2; 27; 29)(H; 31; 33)(H; 34; 35)/t15-/m1/s1
InChi Key
UZIATSFXNVOVFE-OAHLLOKOSA-N
SMILES
CC(C)OC1=CC(=C(C=C1)F)C2=CN=C(C(=N2)C(=O)NC3=C(C=CN=C3)N4CCCC(C4)C(=O)O)N
CAS Number
2041073-22-5
PubChem CID
139600315

Product Categories/Family for GNF-4877 biochemical

Web Categories; Enzyme Inhibitors; Protein Kinase Inhibitors; Protein Kinase Inhibitors (A-Z); Enzyme Inhibitors (A-Z); Biochemicals; Biochemicals; Biochemicals (A-Z); GSK Inhibitors; DYRK Inhibitors

Structure of GNF-4877 biochemical

GNF-4877 Biochemical – Cat# MBS8400360

Product References and Citations for GNF-4877 biochemical

https://pubchem.ncbi.nlm.nih.gov/compound/139600315

Other Notes

Small volumes of GNF-4877 biochemical vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for GNF-4877 purchase

MBS8400360 is a biochemical targeting GNF-4877.
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