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LLY-283

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS8400389

LLY-283 is a potent, selective protein arginine methyltransferase 5 (PRMT5) inhibitor (IC50 = 22nM). It is selective for PRMT5 over a panel of 32 methyltransferases, including PRMT4, -6, and -7 at 1uM. LLY-283 reduces proliferation of various breast, gastric,… More details

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Product Documentation
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Sample Manual Insert View PDF
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Testing Data View PDF
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Certificate of Analysis (COA) View PDF
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QC Report View PDF
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Material Safety Data Sheet View PDF
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Technical Datasheet View PDF
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Protocol View PDF

Product Overview

Product Name
LLY-283, Biochemical
Full Product Name
LLY-283
Product Gene Name
LLY-283 biochemical
Product Synonym Names
(2R, 3R, 4S, 5R)-2-(4-Amino-7H-pyrrolo[2, 3-d]pyrimidin-7-yl)-5-((R)-hydroxy(phenyl)methyl)tetrahydrofuran-3, 4-diol, (R)-5-phenyl-7-deazaadenosine; 6-amino-9-[(R)-5-phenyl(ribofuranosyl)]-7-deazapurine, LLY283
Form/Format
White to off-white solid
Purity/Purification
>=98% by HPLC
Specificity
A potent and selective SAM-competitive PRMT5 inhibitor
Preparation and Storage
Store at -20 degree C
Do not take internally. Wear gloves and mask when handling the product! Avoid contact by all modes of exposure.
Shipping: Gel Pack
Shelf Life: Est.~36 months
Country of Origin: USA
Molecular Weight
342.35
Solubilities
>50mg/ml DMSO
Molecular Formula
C??H??N?O?
InChi
InChI=1S/C17H18N4O4/c18-15-10-6-7-21(16(10)20-8-19-15)17-13(24)12(23)14(25-17)11(22)9-4-2-1-3-5-9/h1-8; 11-14; 17; 22-24H; (H2; 18; 19; 20)/t11-; 12+; 13-; 14-; 17-/m1/s1
InChi Key
WWOOWAHTEXIWBO-QFRSUPTLSA-N
SMILES
C1=CC=C(C=C1)C(C2C(C(C(O2)N3C=CC4=C(N=CN=C43)N)O)O)O
CAS Number
2040291-27-6
PubChem CID
122669401

Product Categories/Family for LLY-283 biochemical

Web Categories; Enzyme Inhibitors; Methyltransferase Inhibitors; Enzyme Inhibitors (A-Z); Biochemicals; Biochemicals (A-Z); Epigenetics; Writer Enzymes; Protein Arginine Methyltransferases (PRMTs); PRMT Inhibitors; Epigenetics; Epigenetic Modulators (A-Z)

Structure of LLY-283 biochemical

LLY-283 Biochemical – Cat# MBS8400389

Product References and Citations for LLY-283 biochemical

https://pubchem.ncbi.nlm.nih.gov/compound/122669401

Other Notes

Small volumes of LLY-283 biochemical vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for LLY-283 purchase

MBS8400389 is a biochemical targeting LLY-283.
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