MKC-8866 (IRE1-IN-8866)

Name: MKC-8866 (IRE1-IN-8866); MyBioSource
Brand: MyBioSource
SKU: MBS8400423
Price: 240 USD
Availability: InStock
Rating: 5 (10 reviews)

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS8400423

MKC-8866 is a potent, and selective IRE1 RNase inhibitor with an IC50 of 0.29?uM in human vitro. MKC-8866 strongly inhibits Dithiothreitol-induced X-box-binding protein 1-spliced (XBP1s) expression with an EC50 of 0.52?uM and unstresses RPMI 8226 cells with… More details

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Product Documentation

Sample Manual Insert View PDF

Testing Data View PDF

Certificate of Analysis (COA) View PDF

QC Report View PDF

Material Safety Data Sheet View PDF

Technical Datasheet View PDF

Protocol View PDF

Product Overview

Product Name

MKC-8866, Biochemical

Full Product Name

MKC-8866

Product Synonym Names

IRE1-IN-8866; MKC8866; 7-Hydroxy-6-methoxy-4-methyl-3-(2-morpholino-2-oxoethyl)-2-oxo-2H-chromene-8-carbaldehyde

Form/Format

Crystalline solid

Purity/Purification

>=98%

Specificity

A selective IRE1 RNase inhibitor

Preparation and Storage

Store at -20 degree C
Do not take internally. Wear gloves and mask when handling the product! Avoid contact by all modes of exposure.
Shipping: Gel Pack
Shelf Life: Est.~36 months
Country of Origin: USA

Molecular Weight

361.35

Solubilities

~ 3mg/ml DMSO

Molecular Formula

C??H??NO?

InChi

InChI=1S/C18H19NO7/c1-10-11-7-14(24-2)16(22)13(9-20)17(11)26-18(23)12(10)8-15(21)19-3-5-25-6-4-19/h7; 9; 22H; 3-6; 8H2; 1-2H3

InChi Key

IFDGMRMUJYGWQQ-UHFFFAOYSA-N

SMILES

O=CC1=C(O)C(OC)=CC2=C1OC(C(CC(N3CCOCC3)=O)=C2C)=O

CAS Number

1338934-59-0

PubChem CID

89542346

Product Categories/Family for MKC-8866 biochemical

Web Categories; Biochemicals; Enzyme Inhibitors; Other Inhibitors; Enzyme Inhibitors (A-Z); Biochemicals (A-Z)

Product References and Citations for MKC-8866 biochemical

https://pubchem.ncbi.nlm.nih.gov/compound/89542346

Other Notes

Small volumes of MKC-8866 biochemical vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for MKC-8866 purchase

MBS8400423 is a biochemical targeting MKC-8866.