Avitinib (Abivertinib)

Name: Avitinib (Abivertinib); MyBioSource
Brand: MyBioSource
SKU: MBS8400439
Price: 240 USD
Availability: InStock
Rating: 5 (10 reviews)

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS8400439

Avitinib is a pyrrolopyrimidine-based, irreversible inhibitor of the epidermal growth factor receptor (EGFR) receptor tyrosine kinase. It inhibits EGFR L858R/T790M double mutations with an IC50 value of 0.18nM which is nearly 43-fold potent over wild-type… More details

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Product Documentation

Sample Manual Insert View PDF

Testing Data View PDF

Certificate of Analysis (COA) View PDF

QC Report View PDF

Material Safety Data Sheet View PDF

Technical Datasheet View PDF

Protocol View PDF

Product Overview

Product Name

Avitinib, Biochemical

Full Product Name

Avitinib

Product Synonym Names

Abivertinib; N-[3-[[2-[3-fluoro-4-(4-methylpiperazin-1-yl)anilino]-7H-pyrrolo[2, 3-d]pyrimidin-4-yl]oxy]phenyl]prop-2-enamide; N-(3-((2-((3-Fluoro-4-(4-methylpiperazin-1-yl)phenyl)amino)-7H-pyrrolo[2, 3-d]pyrimidin-4-yl)oxy)phenyl)acrylamide; AC0010

Form/Format

White to off-White Powder

Purity/Purification

>98%

Specificity

An irreversible EGFR inhibitor

Preparation and Storage

Store at -20 degree C
Do not take internally. Wear gloves and mask when handling the product! Avoid contact by all modes of exposure.
Shelf Life: Est.~36 months
Country of Origin: USA

Molecular Weight

487.53

Solubilities

~30mg/ml in DMSO; ethanol; DMF

Molecular Formula

C??H??FN?O?

InChi

InChI=1S/C26H26FN7O2/c1-3-23(35)29-17-5-4-6-19(15-17)36-25-20-9-10-28-24(20)31-26(32-25)30-18-7-8-22(21(27)16-18)34-13-11-33(2)12-14-34/h3-10; 15-16H; 1; 11-14H2; 2H3; (H; 29; 35)(H2; 28; 30; 31; 32)

InChi Key

UOFYSRZSLXWIQB-UHFFFAOYSA-N

SMILES

CN1CCN(CC1)C2=C(C=C(C=C2)NC3=NC4=C(C=CN4)C(=N3)OC5=CC=CC(=C5)NC(=O)C=C)F

CAS Number

1557267-42-1

MDL Number

MFCD29089376

PubChem CID

72734520

Product Categories/Family for Avitinib biochemical

Web Categories; Enzyme Inhibitors; Protein Kinase Inhibitors; Protein Kinase Inhibitors (A-Z); Cancer Research; Oncogenic Signaling Pathway; EGFR Signaling; EGFR Inhibitors; Enzyme Inhibitors (A-Z); Protein Kinase Inhibitors (A-Z); Signaling Pathways; Bio

Product References and Citations for Avitinib biochemical

https://pubchem.ncbi.nlm.nih.gov/compound/72734520

Other Notes

Small volumes of Avitinib biochemical vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for Avitinib purchase

MBS8400439 is a biochemical targeting Avitinib.