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Selpercatinib

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS8400440

Selpercatinib is a RET kinase inhibitor with IC50 values ranging from 1nM to 4nM for wild type and mutant RET kinase. It has shown promising results in early phase clinical trials for RET-driven lung tumours with enhanced clinical activity and better… More details

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Product Documentation
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Sample Manual Insert View PDF
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Testing Data View PDF
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Certificate of Analysis (COA) View PDF
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QC Report View PDF
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Material Safety Data Sheet View PDF
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Technical Datasheet View PDF
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Protocol View PDF

Product Overview

Product Name
Selpercatinib, Biochemical
Full Product Name
Selpercatinib
Product Synonym Names
6-(2-hydroxy-2-methylpropoxy)-4-[6-[6-[(6-methoxypyridin-3-yl)methyl]-3, 6-diazabicyclo[3.1.1]heptan-3-yl]pyridin-3-yl]pyrazolo[1, 5-a]pyridine-3-carbonitrile; LOXO-292
Form/Format
White to off-White powder
Purity/Purification
>98%
Specificity
A RET kinase inhibitor
Preparation and Storage
Store at -20 degree C
Do not take internally. Wear gloves and mask when handling the product! Avoid contact by all modes of exposure.
Shelf Life: Est.~36 months
Country of Origin: USA
Molecular Weight
525.6
Solubilities
~8mg/ml in DMSO.ultrasonication can be done to improve solubility.
Molecular Formula
C??H??N?O?
InChi
InChI=1S/C29H31N7O3/c1-29(2; 37)18-39-24-9-25(28-21(10-30)13-33-36(28)17-24)20-5-6-26(31-12-20)34-15-22-8-23(16-34)35(22)14-19-4-7-27(38-3)32-11-19/h4-7; 9; 11-13; 17; 22-23; 37H; 8; 14-16; 18H2; 1-3H3
InChi Key
XIIOFHFUYBLOLW-UHFFFAOYSA-N
SMILES
CC(C)(COC1=CN2C(=C(C=N2)C#N)C(=C1)C3=CN=C(C=C3)N4CC5CC(C4)N5CC6=CN=C(C=C6)OC)O
CAS Number
2152628-33-4
PubChem CID
134436906

Product Categories/Family for Selpercatinib biochemical

Web Categories; Enzyme Inhibitors; Protein Kinase Inhibitors; Protein Kinase Inhibitors (A-Z); Enzyme Inhibitors (A-Z); Biochemicals; Biochemicals (A-Z); Other Protein Kinase Inhibitors

Structure of Selpercatinib biochemical

Selpercatinib Biochemical – Cat# MBS8400440

Product References and Citations for Selpercatinib biochemical

https://pubchem.ncbi.nlm.nih.gov/compound/134436906

Other Notes

Small volumes of Selpercatinib biochemical vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for Selpercatinib purchase

MBS8400440 is a biochemical targeting Selpercatinib.
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