Theliatinib (HMPL-309)

Name: Theliatinib (HMPL-309); MyBioSource
Brand: MyBioSource
SKU: MBS8400445
Price: 275 USD
Availability: InStock
Rating: 5 (10 reviews)

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS8400445

Theliatinib is a potent epidermal growth factor receptor EGFR tyrosine kinase inhibitor with a Ki value of 0.05nM and IC50 of 3nM. It exhibits strong antitumor activity in patient-derived estrogen cancer xenograft (PDECX) models with high EGFR expression,… More details

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Product Documentation

Sample Manual Insert View PDF

Testing Data View PDF

Certificate of Analysis (COA) View PDF

QC Report View PDF

Material Safety Data Sheet View PDF

Technical Datasheet View PDF

Protocol View PDF

Product Overview

Product Name

Theliatinib, Biochemical

Full Product Name

Theliatinib

Product Synonym Names

HMPL-309; (3aR, 6aR)-N-[4-(3-ethynylanilino)-7-methoxyquinazolin-6-yl]-1-methyl-2, 3, 3a, 4, 6, 6a-hexahydropyrrolo[2, 3-c]pyrrole-5-carboxamide

Form/Format

Solid

Purity/Purification

>98%

Specificity

A potent and selective EGFR inhibitor

Preparation and Storage

Store at -20 degree C
Do not take internally. Wear gloves and mask when handling the product! Avoid contact by all modes of exposure.
Shelf Life: Est.~36 months
Country of Origin: USA

Molecular Weight

442.5

Solubilities

~5mg/ml in DMSO. May needultrasonication.

Molecular Formula

C??H??N?O?

InChi

InChI=1S/C25H26N6O2/c1-4-16-6-5-7-18(10-16)28-24-19-11-21(23(33-3)12-20(19)26-15-27-24)29-25(32)31-13-17-8-9-30(2)22(17)14-31/h1; 5-7; 10-12; 15; 17; 22H; 8-9; 13-14H2; 2-3H3; (H; 29; 32)(H; 26; 27; 28)/t17-; 22+/m1/s1

InChi Key

FSXCKIBROURMFT-VGSWGCGISA-N

SMILES

CN1CCC2C1CN(C2)C(=O)NC3=C(C=C4C(=C3)C(=NC=N4)NC5=CC=CC(=C5)C#C)OC

CAS Number

1353644-70-8

PubChem CID

54759275

Product Categories/Family for Theliatinib biochemical

Web Categories; Enzyme Inhibitors; Protein Kinase Inhibitors; Protein Kinase Inhibitors (A-Z); Enzyme Inhibitors (A-Z); Biochemicals; Biochemicals (A-Z); Other Protein Kinase Inhibitors

Product References and Citations for Theliatinib biochemical

https://pubchem.ncbi.nlm.nih.gov/compound/54759275

Other Notes

Small volumes of Theliatinib biochemical vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for Theliatinib purchase

MBS8400445 is a biochemical targeting Theliatinib.