Roblitinib (FGF401)

Name: Roblitinib (FGF401); MyBioSource
Brand: MyBioSource
SKU: MBS8400449
Price: 190 USD
Availability: InStock
Rating: 5 (10 reviews)

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS8400449

Roblitinib is a reversible-covalent inhibitor of fibroblast growth factor receptor 4 (FGFR4) tyrosine kinase. It shows 1000-fold selectivity for FGFR4 over FGFR1/2/3 and other kinases, with an IC50 value of 1.9nM against FGFR4. It shows potent antitumor… More details

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Product Documentation

Sample Manual Insert View PDF

Testing Data View PDF

Certificate of Analysis (COA) View PDF

QC Report View PDF

Material Safety Data Sheet View PDF

Technical Datasheet View PDF

Protocol View PDF

Product Overview

Product Name

Roblitinib, Biochemical

Full Product Name

Roblitinib

Product Synonym Names

FGF401; N-[5-cyano-4-(2-methoxyethylamino)pyridin-2-yl]-7-formyl-6-[(4-methyl-2-oxopiperazin-1-yl)methyl]-3, 4-dihydro-2H-1, 8-naphthyridine-1-carboxamide; N-(5-cyano-4-((2-methoxyethyl)amino)pyridin-2-yl)-7-formyl-6-((4-methyl-2-oxopiperazin-1-yl)methyl)-3, 4-dihydro-1, 8-naphthyridine-1(2H)-carboxamide

Form/Format

Pale-yellow Solid

Purity/Purification

>98%

Specificity

A potent inhibitor of FGFR4

Preparation and Storage

Store at -20 degree C
Do not take internally. Wear gloves and mask when handling the product! Avoid contact by all modes of exposure.
Shelf Life: Est.~36 months
Country of Origin: USA

Molecular Weight

506.6

Solubilities

~5mg/ml in DMSO (gently warm and vortex)

Molecular Formula

C??H??N?O?

InChi

InChI=1S/C25H30N8O4/c1-31-7-8-32(23(35)15-31)14-18-10-17-4-3-6-33(24(17)29-21(18)16-34)25(36)30-22-11-20(27-5-9-37-2)19(12-26)13-28-22/h10-11; 13; 16H; 3-9; 14-15H2; 1-2H3; (H2; 27; 28; 30; 36)

InChi Key

BHKDKKZMPODMIQ-UHFFFAOYSA-N

SMILES

CN1CCN(C(=O)C1)CC2=C(N=C3C(=C2)CCCN3C(=O)NC4=NC=C(C(=C4)NCCOC)C#N)C=O

CAS Number

1708971-55-4

MDL Number

MFCD31381923

PubChem CID

118036971

Product Categories/Family for Roblitinib biochemical

Web Categories; Enzyme Inhibitors; Protein Kinase Inhibitors; Protein Kinase Inhibitors (A-Z); Enzyme Inhibitors (A-Z); Biochemicals; Biochemicals (A-Z); Other Protein Kinase Inhibitors

Product References and Citations for Roblitinib biochemical

https://pubchem.ncbi.nlm.nih.gov/compound/118036971

Other Notes

Small volumes of Roblitinib biochemical vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for Roblitinib purchase

MBS8400449 is a biochemical targeting Roblitinib.