MGL-3196 (Resmetirom)

Name: MGL-3196 (Resmetirom); MyBioSource
Brand: MyBioSource
SKU: MBS8400451
Price: 190 USD
Availability: InStock
Rating: 5 (10 reviews)

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS8400451

A selective thyroid hormone receptor beta agonist with EC50 values of 0.21 and 3.74uM for THRbeta and THRalpha, respectively. It significantly lowers non-HDL-C and liver TG in hypercholesterolemic rat and rabbit models at doses where there is no effect on TSH… More details

DISCONTINUED
Click here to view our similar product(s) OR click here to contact our technical support team for suitable replacement.

Product Documentation

Sample Manual Insert View PDF

Testing Data View PDF

Certificate of Analysis (COA) View PDF

QC Report View PDF

Material Safety Data Sheet View PDF

Technical Datasheet View PDF

Protocol View PDF

Product Overview

Product Name

MGL-3196, Biochemical

Full Product Name

MGL-3196

Product Gene Name

MGL-3196 biochemical

Product Synonym Names

Resmetirom; VIA-3196; 2-[3, 5-dichloro-4-[(6-oxo-5-propan-2-yl-1H-pyridazin-3-yl)oxy]phenyl]-3, 5-dioxo-1, 2, 4-triazine-6-carbonitrile; 2-(3, 5-dichloro-4-((5-isopropyl-6-oxo-1, 6-dihydropyridazin-3-yl)oxy)phenyl)-3, 5-dioxo-2, 3, 4, 5-tetrahydro-1, 2, 4-triazine-6-carbonitrile; 1, 2, 4-Triazine-6-carbonitrile; 2-(3, 5-dichloro-4-{[6-hydroxy-5-(propan-2-yl)pyridazin-3-yl]oxy}phenyl)-5-hydroxy-3-oxo-2, 3-dihydro-1, 2, 4-triazine-6-carbonitrile

Form/Format

Light yellow powder

Purity/Purification

0.98

Specificity

A selective thyroid hormone receptor beta agonist

Preparation and Storage

Store at -20 degree C
Do not take internally. Wear gloves and mask when handling the product! Avoid contact by all modes of exposure.
Shelf Life: Est.~36months
Country of Origin: USA

Molecular Weight

435.2

Solubilities

~20mg/ml in DMSO and DMF; ~1mg/ml in Ethanol

Molecular Formula

C??H??Cl?N?O?

InChi

InChI=1S/C17H12Cl2N6O4/c1-7(2)9-5-13(22-23-15(9)26)29-14-10(18)3-8(4-11(14)19)25-17(28)21-16(27)12(6-20)24-25/h3-5; 7H; 1-2H3; (H; 23; 26)(H; 21; 27; 28)

InChi Key

FDBYIYFVSAHJLY-UHFFFAOYSA-N

SMILES

CC(C)C1=CC(=NNC1=O)OC2=C(C=C(C=C2Cl)N3C(=O)NC(=O)C(=N3)C#N)Cl

CAS Number

920509-32-6

MDL Number

MFCD26142653

PubChem CID

15981237

Product Categories/Family for MGL-3196 biochemical

Web Categories; Biochemicals; Biochemicals (A-Z); Cardiovascular Research; Atherosclerosis; Antihyperlipidemics

Product References and Citations for MGL-3196 biochemical

https://pubchem.ncbi.nlm.nih.gov/compound/15981237

Other Notes

Small volumes of MGL-3196 biochemical vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for MGL-3196 purchase

MBS8400451 is a biochemical targeting MGL-3196.