GBT-440 (Voxelotor)

Name: GBT-440 (Voxelotor); MyBioSource
Brand: MyBioSource
SKU: MBS8400472
Price: 265 USD
Availability: InStock
Rating: 5 (10 reviews)

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS8400472

GTB-440 is a modulator of sickle hemoglobin S (HbS). It binds to the N?terminal valine of one of the haemoglobin alpha chains and increases HbS affinity for oxygen. GBT440 dose?dependently increases HbS affinity for oxygen (EC50 = 8·2uM) for purified HbS and… More details

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Product Documentation

Sample Manual Insert View PDF

Testing Data View PDF

Certificate of Analysis (COA) View PDF

QC Report View PDF

Material Safety Data Sheet View PDF

Technical Datasheet View PDF

Protocol View PDF

Product Overview

Product Name

GBT-440, Biochemical

Full Product Name

GBT-440

Product Synonym Names

Voxelotor; Hemoglobin Modulators-1; 2-hydroxy-6-[[2-(2-propan-2-ylpyrazol-3-yl)pyridin-3-yl]methoxy]benzaldehyde; 2-hydroxy-6-((2-(1-isopropyl-1H-pyrazol-5-yl)pyridin-3-yl)methoxy)benzaldehyde; 2-hydroxy-6-((2-(1-(propan-2-yl)-1H-pyrazol-5-yl)pyridin-3-yl)methoxy)benzaldehyde; Benzaldehyde, 2-hydroxy-6-((2-(1-(1-methylethyl)-1H-pyrazol-5-yl)-3-pyridinyl)methoxy)-

Form/Format

White to off-white solid powder

Purity/Purification

>=98%

Specificity

A modulator of sickle hemoglobin S (HbS)

Preparation and Storage

Store at -20 degree C
Do not take internally. Wear gloves and mask when handling the product! Avoid contact by all modes of exposure.
Shelf Life: Est.~36 months
Country of Origin: USA

Molecular Weight

337.37

Solubilities

~33mg/ml in DMSO and DMF; ~20mg/ml in ethanol

Molecular Formula

C??H??N?O?

InChi

InChI=1S/C19H19N3O3/c1-13(2)22-16(8-10-21-22)19-14(5-4-9-20-19)12-25-18-7-3-6-17(24)15(18)11-23/h3-11; 13; 24H; 12H2; 1-2H3

InChi Key

FWCVZAQENIZVMY-UHFFFAOYSA-N

SMILES

CC(C)N1C(=CC=N1)C2=C(C=CC=N2)COC3=CC=CC(=C3C=O)O

CAS Number

1446321-46-5

MDL Number

MFCD29053764

PubChem CID

71602803

Product Categories/Family for GBT-440 biochemical

Web Categories; Biochemicals; Enzyme Inhibitors; Other Inhibitors; Biochemicals (A-Z); Enzyme Inhibitors (A-Z)

Product References and Citations for GBT-440 biochemical

https://pubchem.ncbi.nlm.nih.gov/compound/71602803

Other Notes

Small volumes of GBT-440 biochemical vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for GBT-440 purchase

MBS8400472 is a biochemical targeting GBT-440.