Cepharanthine

Cepharanthine is an alkaloid extracted from the plant Stephania cepharantha Hayata. It shows antimalarial, antiviral, anti-inflammatory, and antitumor activities. The IC50 values against different strains of Plasmodium falciparum range beween 0.927uM and 3.06uM. It (10uM) causes cell cycle arrest at G(1) phase, induces apoptosis and decreases the expression of STAT3 in SaOS2 Human osteosarcoma cells. It (20mg/kg/day, ip for 19 days) significantly reduces the volume and weight of the tumor in nude mouse xenografts of SaOS2 cells. It reduces pro-inflammatory cytokines, including TNF-alpha, IL-1beta, and IL-6 in RAW264.7 cells and mouse models. It inhibits the HIV-1 entry process by reducing plasma membrane fluidity. It inhibits the cytopathic effect in 2019-nCoV-related coronaviruses (2019-nCoVr) infected cells.

https://pubchem.ncbi.nlm.nih.gov/compound/10206

Small volumes of Cepharanthine biochemical vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

MBS8400482 is a biochemical targeting Cepharanthine.