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BAY-678

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS8400501

BAY-678 is a potent, selective, cell-permeable inhibitor of human neutrophil elastase (HNE).The activity of HNE is increased in inflammatory diseases. BAY-678 shows Ki values of 15nM and 600nM for human and rat neutrophil elastase respectively and IC50 of… More details

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Product Documentation
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Sample Manual Insert View PDF
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Testing Data View PDF
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Certificate of Analysis (COA) View PDF
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Material Safety Data Sheet View PDF
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Technical Datasheet View PDF
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Product Overview

Product Name
BAY-678, Biochemical
Full Product Name
BAY-678
Product Gene Name
BAY-678 biochemical
Product Synonym Names
5-[(6R)-5-acetyl-4-methyl-2-oxo-3-[3-(trifluoromethyl)phenyl]-1, 6-dihydropyrimidin-6-yl]pyridine-2-carbonitrile; (R)-5-(5-Acetyl-6-methyl-2-oxo-1-(3-(trifluoromethyl)phenyl)-1, 2, 3, 4-tetrahydropyrimidin-4-yl)picolinonitrile; 5-[(4R)-5-Acetyl-1, 2, 3, 4-tetrahydro-6-methyl-2-oxo-1-[3-(trifluoromethyl)phenyl]-4-pyrimidinyl]-2-pyridinecarbonitrile
Form/Format
Yellow solid
Purity/Purification
>=98%
Specificity
An inhibitor of human neutrophil elastase
Preparation and Storage
Store at -20 degree C
Do not take internally. Wear gloves and mask when handling the product! Avoid contact by all modes of exposure.
Shelf Life: Est.~36 months
Country of Origin: USA
Molecular Weight
400.35
Solubilities
~20mg/ml in DMSO
Molecular Formula
C??H??F?N?O?
InChi
InChI=1S/C20H15F3N4O2/c1-11-17(12(2)28)18(13-6-7-15(9-24)25-10-13)26-19(29)27(11)16-5-3-4-14(8-16)20(21; 22)23/h3-8; 10; 18H; 1-2H3; (H; 26; 29)/t18-/m1/s1
InChi Key
PGIVGIFOWOVINL-GOSISDBHSA-N
SMILES
CC1=C(C(NC(=O)N1C2=CC=CC(=C2)C(F)(F)F)C3=CN=C(C=C3)C#N)C(=O)C
CAS Number
675103-36-3
MDL Number
MFCD29924806
PubChem CID
23728722

Product Categories/Family for BAY-678 biochemical

Web Categories; Biochemicals; Enzyme Inhibitors; Protease Inhibitors; Enzyme Inhibitors (A-Z); Biochemicals (A-Z); Elastase Inhibitors

Structure of BAY-678 biochemical

BAY-678 Biochemical – Cat# MBS8400501

Product References and Citations for BAY-678 biochemical

https://pubchem.ncbi.nlm.nih.gov/compound/23728722

Other Notes

Small volumes of BAY-678 biochemical vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for BAY-678 purchase

MBS8400501 is a biochemical targeting BAY-678.
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