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CHIR-124

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS8400509

CHIR-124 is a quinolone-based inhibitor of Checkpoint kinase-1 (Chk1). It potently and selectively inhibits Chk1 in vitro with an IC50 of 0.3nM. It interacts synergistically with topoisomerase poisons (e.g., camptothecin) in inhibiting the growth of several… More details

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Product Documentation
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Sample Manual Insert View PDF
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Testing Data View PDF
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Certificate of Analysis (COA) View PDF
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QC Report View PDF
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Material Safety Data Sheet View PDF
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Technical Datasheet View PDF
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Protocol View PDF

Product Overview

Product Name
CHIR-124, Biochemical
Full Product Name
CHIR-124
Product Gene Name
CHIR-124 biochemical
Product Synonym Names
4-[[(3S)-1-azabicyclo[2.2.2]octan-3-yl]amino]-3-(1H-benzimidazol-2-yl)-6-chloro-1H-quinolin-2-one; (S)-3-(1H-benzo[d]imidazol-2-yl)-6-chloro-4-(quinuclidin-3-ylamino)quinolin-2(1H)-one
Form/Format
Brown Solid
Purity/Purification
>=98%
Specificity
An inhibitor of Checkpoint kinase-1
Preparation and Storage
Store at -20 degree C
Do not take internally. Wear gloves and mask when handling the product! Avoid contact by all modes of exposure.
Shelf Life: Est.~36 months
Country of Origin: USA
Molecular Weight
419.91
Solubilities
~10mg/ml in DMSO; ~3mg/ml in DMF
Molecular Formula
C??H??ClN?O
InChi
InChI=1S/C23H22ClN5O/c24-14-5-6-16-15(11-14)21(25-19-12-29-9-7-13(19)8-10-29)20(23(30)28-16)22-26-17-3-1-2-4-18(17)27-22/h1-6; 11; 13; 19H; 7-10; 12H2; (H; 26; 27)(H2; 25; 28; 30)/t19-/m1/s1
InChi Key
MOVBBVMDHIRCTG-LJQANCHMSA-N
SMILES
C1CN2CCC1C(C2)NC3=C(C(=O)NC4=C3C=C(C=C4)Cl)C5=NC6=CC=CC=C6N5
CAS Number
405168-58-3
MDL Number
MFCD31656992
PubChem CID
135399748

Product Categories/Family for CHIR-124 biochemical

Web Categories; Biochemicals; Enzyme Inhibitors; Protein Kinase Inhibitors; Chk Kinase Inhibitors; Protein Kinase Inhibitors (A-Z); Enzyme Inhibitors (A-Z); Biochemicals (A-Z); Anticancer Agents

Structure of CHIR-124 biochemical

CHIR-124 Biochemical – Cat# MBS8400509

Product References and Citations for CHIR-124 biochemical

https://pubchem.ncbi.nlm.nih.gov/compound/135399748

Other Notes

Small volumes of CHIR-124 biochemical vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for CHIR-124 purchase

MBS8400509 is a biochemical targeting CHIR-124.
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