Afatinib Dimaleate (Gilotrif)

Name: Afatinib Dimaleate (Gilotrif); MyBioSource
Brand: MyBioSource
SKU: MBS8400512
Price: 185 USD
Availability: InStock
Rating: 5 (10 reviews)

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS8400512

Afatinib is an irreversible dual inhibitor of epidermal growth factor receptor (EGFR) and human epidermal growth factor receptor 2 (HER2) tyrosine kinase. It shows IC50 values of 0.5nM and 14nM for EGFR kinase and HER2 kinase respectively. It inhibits… More details

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Product Documentation

Sample Manual Insert View PDF

Testing Data View PDF

Certificate of Analysis (COA) View PDF

QC Report View PDF

Material Safety Data Sheet View PDF

Technical Datasheet View PDF

Protocol View PDF

Product Overview

Product Name

Afatinib dimaleate, Biochemical

Full Product Name

Afatinib dimaleate

Product Synonym Names

Gilotrif; (2E)-N-(4-((3-Chloro-4-fluorophenyl)amino)-7-(((3S)-tetrahydrofuran-3-yl)oxy)quinazolin- 6-yl)-4-(dimethylamino)but-2-enamide bis(hydrogen (2Z)-but-2-enedioate); (2E)-N-[4-[(3-Chloro-4-fluorophenyl)amino]-7-[[(3S)-tetrahydro-3-furanyl]oxy]-6-quinazolinyl]-4-(dimethylamino)-2-butenamide dimaleate; (E)-4-Dimethylamino-But-2-Enoic Acid-(4-(3-Chloro-4-Fluoro-Phenylamino)-7-((S)-Tetra-Hydrofuran-3-Yloxy)-Quinazolin-6Yl)-Amide Dimaleate; BIBW 2992MA2; Tovok

Form/Format

White to off-white powder

Purity/Purification

>=95%

Specificity

An inhibitor of EGFR and HER2

Preparation and Storage

Store at -20 degree C
Do not take internally. Wear gloves and mask when handling the product! Avoid contact by all modes of exposure.
Shelf Life: Est.~36 months
Country of Origin: USA

Molecular Weight

718.08

Solubilities

~ 50mg/ml in water

Molecular Formula

C??H??ClFN?O??

InChi

InChI=1S/C24H25ClFN5O3.2C4H4O4/c1-31(2)8-3-4-23(32)30-21-11-17-20(12-22(21)34-16-7-9-33-13-16)27-14-28-24(17)29-15-5-6-19(26)18(25)10-15;2*5-3(6)1-2-4(7)8/h3-6; 10-12; 14; 16H; 7-9; 13H2; 1-2H3; (H; 30; 32)(H; 27; 28; 29);2*1-2H; (H; 5; 6)(H; 7; 8)/b4-3+;2*2-1-/t16-;;/m0../s1

InChi Key

USNRYVNRPYXCSP-JUGPPOIOSA-N

SMILES

CN(C)CC=CC(=O)NC1=C(C=C2C(=C1)C(=NC=N2)NC3=CC(=C(C=C3)F)Cl)OC4CCOC4.C(=CC(=O)O)C(=O)O.C(=CC(=O)O)C(=O)O

CAS Number

850140-73-7

MDL Number

MFCD25974239

PubChem CID

15606394

Product Categories/Family for Afatinib dimaleate biochemical

Web Categories; Enzyme Inhibitors; Protein Kinase Inhibitors; Protein Kinase Inhibitors (A-Z); Cancer Research; Oncogenic Signaling Pathway; Signaling Pathways; EGFR Signaling; EGFR Inhibitors; Biochemicals; Biochemicals (A-Z); Protein Tyrosine Kinase Inh

Product References and Citations for Afatinib dimaleate biochemical

https://pubchem.ncbi.nlm.nih.gov/compound/15606394

Other Notes

Small volumes of Afatinib dimaleate biochemical vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for Afatinib dimaleate purchase

MBS8400512 is a biochemical targeting Afatinib dimaleate.