PBR Antibody – Rabbit Polyclonal

TSPO: Responsible for the manifestation of peripheral-type benzodiazepine recognition sites and is most likely to comprise binding domains for benzodiazepines and isoquinoline carboxamides. May play a role in the transport of porphyrins and heme. Plays a role in the transport of cholesterol across mitochondrial membranes in steroidogenic cells. Belongs to the TspO/BZRP family. Interacts with BZRAP1. May interact with STAR. Interacts with MOST-1. 2 isoforms of the human protein are produced by alternative splicing.

Protein type: Apoptosis; Mitochondrial; Receptor, misc.; Membrane protein, multi-pass; Membrane protein, integral

Cellular Component: mitochondrial outer membrane; nuclear membrane; membrane; intracellular membrane-bound organelle; mitochondrion; cytoplasm; integral to membrane

Molecular Function: androgen binding; benzodiazepine receptor activity

Biological Process: positive regulation of apoptosis; negative regulation of nitric oxide biosynthetic process; chloride transport; regulation of steroid biosynthetic process; negative regulation of tumor necrosis factor production; glial cell migration; signal transduction; lipid transport; synaptic transmission; behavioral response to pain; positive regulation of mitochondrial depolarization; transport; ion transport; positive regulation of calcium ion transport; steroid biosynthetic process