CREB Antibody – Rabbit Polyclonal

CREB: a transcription factor of the leucine zipper family of DNA binding proteins. Binds as a homodimer to the cAMP-responsive element (CRE). Phosphorylated by several protein kinases, and induces transcription of genes in response to hormonal stimulation of the cAMP pathway. Two splice-variant isoforms have been described.

Protein type: DNA-binding; Transcription factor

Cellular Component: nucleoplasm; transcription factor complex; mitochondrion; nuclear chromatin; chromatin; nucleus

Molecular Function: RNA polymerase II transcription factor activity, enhancer binding; histone acetyltransferase binding; protein binding; enzyme binding; DNA binding; sequence-specific DNA binding; double-stranded DNA binding; transcription factor binding; transcription factor activity

Biological Process: circadian rhythm; transcription from RNA polymerase II promoter; lactation; response to glucagon stimulus; positive regulation of osteoclast differentiation; positive regulation of transcription, DNA-dependent; positive regulation of multicellular organism growth; protein amino acid phosphorylation; response to organic substance; regulation of apoptosis; regulation of transcription, DNA-dependent; mammary gland development; positive regulation of transforming growth factor-beta3 production; transforming growth factor beta receptor signaling pathway; cell differentiation; positive regulation of transcriptional preinitiation complex assembly; response to drug; protein stabilization; secretory granule organization and biogenesis; positive regulation of hormone secretion; positive regulation of lipid biosynthetic process; regulation of circadian rhythm; memory; axonogenesis; pituitary gland development; positive regulation of fat cell differentiation; positive regulation of transcription from RNA polymerase II promoter; regulation of cell size