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CD62L Antibody – Polyclonal

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS177770

Description: Rabbit IgG polyclonal antibody for L-selectin(SELL) detection. Tested with WB, IHC-P, ELISA in Human;Mouse;Rat.Background: CD62L, also known as L-selectin, is a cell adhesion molecule found on leukocytes. It belongs to the selectin family of… More details

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Product Overview

Online Datasheet in PDF
Product Name
CD62L, Polyclonal Antibody
Full Product Name
Anti-CD62L Antibody
Product Gene Name
anti-CD62L antibody
Product Synonym Names
L-selectin; A.11; AI528707; CD62 antigen ligand; CD62 antigen-like family member L; CD62L; gp90 MEL; gp90-MEL; hLHRc; IgA nephropathy, susceptibility to, included; L Selectin; L-selectin; LAM-1; LAM1; LECAM1; LEU8; Leukocyte adhesion molecule 1; Leukocyte surface antigen Leu-8; Leukocyte surface antigen Leu8; Leukocyte-endothelial cell adhesion molecule 1; LNHR; LSEL; Ly-22; Ly-m22; Lyam-1; LYAM1; LYAM1_HUMAN; Lymph node homing receptor; Lymphocyte adhesion molecule 1; Lymphocyte antigen 22; Lymphocyte surface MEL-14 antigen; MEL-14; Pln homing receptor; PLNHR; Selectin L; Selectin, lymphocyte; SELL; TQ1; selectin L
Clonality
Polyclonal
Species Reactivity
Human, Mouse, Rat
Form/Format
Lyophilized. Each vial contains 5mg BSA, 0.9mg NaCl, 0.2mg Na2HPO4, 0.05mg NaN3.
Purity/Purification
Immunogen Affinity Purified
Preparation and Storage
At -20 degree C for one year. After reconstitution, at 4 degree C for one month. It can also be aliquoted and stored frozen at -20 degree C for a longer time. Avoid repeated freezing and thawing.
Molecular Weight
43,618 Da
OMIM
153240
3D Structure
ModBase 3D Structure for P14151
Immunogen
E Coli-derived human CD62L recombinant protein (Position: W39-Y372). Human CD62L shares 77.5 % and 78.7 % amino acid (aa) sequence identity with mouse and rat CD62L, respectively.
Ig Type
Rabbit IgG
Reconstitution
Add 0.2ml of distilled water will yield a concentration of 500ug/ml.
ISO Certification
Manufactured in an ISO 13485:2003 and EN ISO 13485:2012 Certified Laboratory.
Applications Tested/Suitable for anti-CD62L antibody
Western Blot (WB), Immunohistochemistry (IHC) Paraffin, ELISA (EIA)
Application Notes for anti-CD62L antibody
ELISA Concentration: 0.1-0.5ug/ml
Western Blot Concentration: 0.1-0.5ug/ml
Immunohistochemistry (IHC) Paraffin Concentration: 0.5-1ug/ml

Immunohistochemistry (IHC) of anti-CD62L antibody

Anti- L-selectin Picoband antibody, MBS177770, IHC(P)
IHC(P): Human Tonsil Tissue
Anti-CD62L Polyclonal Antibody – Cat# MBS177770

Western Blot (WB) of anti-CD62L antibody

Anti- L-selectin Picoband antibody, MBS177770, Western blotting
All lanes: Anti L-selectin (MBS177770) at 0.5ug/ml
Lane 1: Human Placenta Tissue Lysate at 50ug
Lane 2: JURKAT Whole Cell Lysate at 40ug
Lane 3: CEM Whole Cell Lysate at 40ug
Lane 4: HL60 Whole Cell Lysate at 40ug
Lane 5: Rat Spleen Tissue Lysate at 50ug
Lane 6: Mouse Spleen Tissue Lysate at 50ug
Predicted bind size: 42KD
Observed bind size: 42KD
Anti-CD62L Polyclonal Antibody, Western Blot (WB) – Cat# MBS177770

Product References and Citations for anti-CD62L antibody

1. "Entrez Gene: SELL selectin L (lymphocyte adhesion molecule 1)". 2. Cotran; Kumar, Collins (1998). Robbins Pathologic Basis of Disease. Philadelphia: W.B Saunders Company.

Other Notes

Small volumes of anti-CD62L antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for CD62L purchase

MBS177770 is an antibody targeting CD62L. Reactive in Human, Mouse, Rat.

Additional Details

NCBI/Uniprot data below describe general gene information for CD62L. It may not necessarily be applicable to this product.

NCBI GI #
262206315
NCBI GeneID
6402
NCBI Accession #
NP_000646.2
UniProt Primary Accession #
P14151
UniProt Secondary Accession #
P15023; Q9UJ43; B2R6Q8
UniProt Related Accession #
P14151
GenBank Nucleotide #
NM_000655.4
NCBI Official Full Name
L-selectin
NCBI Official Synonym Full Names
selectin L
NCBI Official Symbol
SELL
NCBI Official Synonym Symbols
TQ1; LAM1; LEU8; LNHR; LSEL; CD62L; LYAM1; PLNHR; LECAM1
UniProt Protein Name
L-selectin
UniProt Synonym Protein Names
CD62 antigen-like family member L; Leukocyte adhesion molecule 1; LAM-1; Leukocyte surface antigen Leu-8; Leukocyte-endothelial cell adhesion molecule 1; LECAM1; Lymph node homing receptor; TQ1; gp90-MEL; CD_antigen: CD62L
Protein Family
L-selectin
UniProt Gene Name
SELL
UniProt Synonym Gene Names
LNHR; LYAM1; LAM-1; LECAM1
UniProt Entry Name
LYAM1_HUMAN
NCBI Protein Information
L-selectin

NCBI Summary for CD62L

This gene encodes a cell surface adhesion molecule that belongs to a family of adhesion/homing receptors. The encoded protein contains a C-type lectin-like domain, a calcium-binding epidermal growth factor-like domain, and two short complement-like repeats. The gene product is required for binding and subsequent rolling of leucocytes on endothelial cells, facilitating their migration into secondary lymphoid organs and inflammation sites. Single-nucleotide polymorphisms in this gene have been associated with various diseases including immunoglobulin A nephropathy. Alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, Oct 2009]
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UniProt Comments for CD62L

SELL: Cell surface adhesion protein. Mediates the adherence of lymphocytes to endothelial cells of high endothelial venules in peripheral lymph nodes. Promotes initial tethering and rolling of leukocytes in endothelia. Belongs to the selectin/LECAM family. 2 isoforms of the human protein are produced by alternative splicing.

Protein type: Membrane protein, integral

Chromosomal Location of Human Ortholog: 1q23-q25

Cellular Component: external side of plasma membrane; integral to plasma membrane; plasma membrane

Molecular Function: carbohydrate binding; cell adhesion molecule binding; glycosphingolipid binding; heparin binding; protease binding; protein binding

Biological Process: cell adhesion; leukocyte migration; regulation of immune response; response to ATP

Disease: Iga Nephropathy, Susceptibility To, 1
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Research Articles on CD62L

1. Modification of Levels of Adhesion Molecule Expression of Human Innate Immune Cells by Glycopolymers of Marine Bacteria

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Products associated with anti-CD62L antibody

 Reference Product  PubMed Publications
 TNF antibody  >27 publications with CD62L and TNF
 CD4 antibody  >26 publications with CD62L and CD4
 SELE antibody  >17 publications with CD62L and SELE
 ITGAM antibody  >3 publications with CD62L and ITGAM
 SELPLG antibody  >2 publications with CD62L and SELPLG
 CD8A antibody  >1 publications with CD62L and CD8A

Pathways associated with anti-CD62L antibody

 Products by Pathway  Pathway Diagram
 Adaptive Immune System Pathway antibodies  Adaptive Immune System Pathway Diagram
 Cell Adhesion Molecules (CAMs) Pathway antibodies  Cell Adhesion Molecules (CAMs) Pathway Diagram
 Cell Adhesion Molecules (CAMs) Pathway antibodies  Cell Adhesion Molecules (CAMs) Pathway Diagram
 Cell Surface Interactions At The Vascular Wall Pathway antibodies  Cell Surface Interactions At The Vascular Wall Pathway Diagram
 Hemostasis Pathway antibodies  Hemostasis Pathway Diagram
 Immune System Pathway antibodies  Immune System Pathway Diagram
 Immunoregulatory Interactions Between A Lymphoid And A Non-Lymphoid Cell Pathway antibodies  Immunoregulatory Interactions Between A Lymphoid And A Non-Lymphoid Cell Pathway Diagram

Diseases associated with anti-CD62L antibody

 Disease Name  Pubmed Publications
 Liver Diseases Antibodies  >121 publications with CD62L and Liver Diseases
 Inflammation Antibodies  >89 publications with CD62L and Inflammation
 Pain Antibodies  >82 publications with CD62L and Pain
 Heart Diseases Antibodies  >79 publications with CD62L and Heart Diseases
 Gastrointestinal Diseases Antibodies  >63 publications with CD62L and Gastrointestinal Diseases
 Lung Diseases Antibodies  >51 publications with CD62L and Lung Diseases
 Necrosis Antibodies  >49 publications with CD62L and Necrosis
 Carcinoma, Hepatocellular Antibodies  >48 publications with CD62L and Carcinoma, Hepatocellular
 Kidney Diseases Antibodies  >41 publications with CD62L and Kidney Diseases
 Fever Antibodies  >32 publications with CD62L and Fever

Organs/Tissues associated with anti-CD62L antibody

 Organ/Tissue Name  Pubmed Publications
 Blood Antibodies  >623 publications with CD62L and Blood
 Liver Antibodies  >196 publications with CD62L and Liver
 Bone Antibodies  >184 publications with CD62L and Bone
 Muscle Antibodies  >155 publications with CD62L and Muscle
 Heart Antibodies  >127 publications with CD62L and Heart
 Vascular Antibodies  >104 publications with CD62L and Vascular
 Kidney Antibodies  >102 publications with CD62L and Kidney
 Brain Antibodies  >99 publications with CD62L and Brain
 Lung Antibodies  >90 publications with CD62L and Lung
 Spleen Antibodies  >73 publications with CD62L and Spleen
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