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Caspase-6 (CASP6) Antibody – Rabbit Polyclonal

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS840174

Background: Caspase-6 is one of the major executioner caspases functioning in cellular apoptotic processes. Similar as other caspases, caspase-6 is also synthesized as an inactive pro-enzyme that is processed in cells undergoing apoptosis. Caspase-6 has also… More details

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Product Overview

Product Name
Caspase-6 (Casp6), Polyclonal Antibody
Full Product Name
Caspase-6 Antibody
Product Gene Name
anti-Casp6 antibody
Product Synonym Names
CASP6; CASP-6; MCH2
Clonality
Polyclonal
Isotype
IgG
Host
Rabbit
Species Reactivity
Human, Mouse, Rat
Form/Format
100 ug (0.2 mg/ml) rabbit anti-caspase-6 polyclonal antibody in phosphate buffered saline (PBS), pH 7.2, containing 30% glycerol, 0.5% BSA, 0.01 thimerosal.
Appearance: Colorless liquid
Purity/Purification
Affinity purified
Concentration
0.2 mg/ml (lot specific)
Preparation and Storage
At -20 degree C
Shelf Life: 12 months
Molecular Weight
31,556 Da
Immunogen
Synthetic peptide mapping to the C-terminus of rat caspase-6 large fragment
Positive Control
Western Blot:Rat kidney tissue lysate, full length and cleaved. IHC: Tonsil tissue
Handling
The antibody solution should be gently mixed before use.
Applications Tested/Suitable for anti-Casp6 antibody
Western Blot (WB), Immunohistochemistry (IHC)
Application Notes for anti-Casp6 antibody
Western blotting (0.5-4 ug/ml), and Immunohistochemistry (5 ug/ml). However, the optimal conditions should be determined individually. Jurkat cell lysate, mouse intestine, and rat kidney tissue lysate can be used as a positive controls. The antibody detects a full length (35 kDa) and the cleaved fragment (18 kDa) of caspase-6.

Testing Data of anti-Casp6 antibody

Rabbit Anti-CASP6 Polyclonal Antibody – Cat# MBS840174

Other Notes

Small volumes of anti-Casp6 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for Casp6 purchase

MBS840174 is an antibody targeting Casp6. Also known as Caspase-6 Antibody. Reactive in Human, Mouse, Rat. Host: Rabbit.

Additional Details

NCBI/Uniprot data below describe general gene information for Casp6. It may not necessarily be applicable to this product.

NCBI GI #
3287307
NCBI GeneID
83584
NCBI Accession #
AAC25433
UniProt Related Accession #
O35397
NCBI Official Full Name
caspase 6
NCBI Official Synonym Full Names
caspase 6
NCBI Official Symbol
Casp6
NCBI Official Synonym Symbols
Mch2
UniProt Protein Name
Caspase-6
UniProt Synonym Protein Names
Apoptotic protease Mch-2
Protein Family
Caspase
UniProt Gene Name
Casp6
UniProt Synonym Gene Names
Mch2; CASP-6
UniProt Entry Name
CASP6_RAT
NCBI Protein Information
caspase-6

NCBI Summary for Casp6

member of the cysteine-aspartic acid protease (caspase) family that plays a terminal role in apoptosis [RGD, Feb 2006]

UniProt Comments for Casp6

CASP6: Involved in the activation cascade of caspases responsible for apoptosis execution. Cleaves poly(ADP-ribose) polymerase in vitro, as well as lamins. Overexpression promotes programmed cell death. Heterotetramer that consists of two anti-parallel arranged heterodimers, each one formed by a 18 kDa (p18) and a 11 kDa (p11) subunit. Interacts with BIRC6/bruce. Activation is suppressed by phosphorylation at Ser-257. Belongs to the peptidase C14A family. 2 isoforms of the human protein are produced by alternative splicing.

Protein type: EC 3.4.22.59; Apoptosis; Protease

Cellular Component: nucleoplasm; cytoplasm; nucleus; cytosol

Molecular Function: identical protein binding; cysteine-type endopeptidase activity; endopeptidase activity

Biological Process: lens development in camera-type eye; response to metal ion; positive regulation of retinal cell programmed cell death; positive regulation of apoptosis; apoptosis; acute inflammatory response to non-antigenic stimulus; response to testosterone stimulus; response to organic nitrogen; proteolysis; response to estradiol stimulus; response to organic substance; epithelial cell differentiation; response to hydrogen peroxide; response to heat; response to cytokine stimulus; positive regulation of neuron apoptosis; response to glucose stimulus; response to gamma radiation; response to iron ion
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Research Articles on Casp6

1. Caspase-6 shows a time-dependent expression in PMNs, MNCs and FBCs during skin injury repair in rat.

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Products associated with anti-Casp6 antibody

 Reference Product  PubMed Publications
 Casp3 antibody  >434 publications with Casp6 and Casp3
 Casp8 antibody  >193 publications with Casp6 and Casp8
 Xiap antibody  >19 publications with Casp6 and Xiap
 Apaf1 antibody  >12 publications with Casp6 and Apaf1
 Satb1 antibody  >6 publications with Casp6 and Satb1
 Birc2 antibody  >4 publications with Casp6 and Birc2
 Birc3 antibody  >4 publications with Casp6 and Birc3
 Lmna antibody  >3 publications with Casp6 and Lmna

Pathways associated with anti-Casp6 antibody

 Products by Pathway  Pathway Diagram
 Apoptosis Pathway antibodies  Apoptosis Pathway Diagram
 Apoptosis Pathway antibodies  Apoptosis Pathway Diagram
 Apoptosis Pathway antibodies  Apoptosis Pathway Diagram
 Apoptosis Pathway antibodies  Apoptosis Pathway Diagram
 Apoptosis Modulation By HSP70 Pathway antibodies  Apoptosis Modulation By HSP70 Pathway Diagram
 Apoptotic Cleavage Of Cellular Proteins Pathway antibodies  Apoptotic Cleavage Of Cellular Proteins Pathway Diagram
 Apoptotic Execution Phase Pathway antibodies  Apoptotic Execution Phase Pathway Diagram
 Breakdown Of The Nuclear Lamina Pathway antibodies  Breakdown Of The Nuclear Lamina Pathway Diagram
 Cardiovascular Signaling Pathway antibodies  Cardiovascular Signaling Pathway Diagram
 Caspase-mediated Cleavage Of Cytoskeletal Proteins Pathway antibodies  Caspase-mediated Cleavage Of Cytoskeletal Proteins Pathway Diagram

Organs/Tissues associated with anti-Casp6 antibody

 Organ/Tissue Name  Pubmed Publications
 Brain Antibodies  >85 publications with Casp6 and Brain
 Lung Antibodies  >34 publications with Casp6 and Lung
 Liver Antibodies  >34 publications with Casp6 and Liver
 Kidney Antibodies  >27 publications with Casp6 and Kidney
 Heart Antibodies  >18 publications with Casp6 and Heart
 Embryonic Tissue Antibodies  >18 publications with Casp6 and Embryonic Tissue
 Prostate Antibodies  >17 publications with Casp6 and Prostate
 Thymus Antibodies  >9 publications with Casp6 and Thymus
 Dorsal Root Ganglion Antibodies  >6 publications with Casp6 and Dorsal Root Ganglion
 Ovary Antibodies  >5 publications with Casp6 and Ovary
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