Rabbit Anti-DR4 Polyclonal Antibody – Cat# MBS840198

DR4 Antibody – Rabbit Polyclonal

Name: DR4 Antibody; Polyclonal; Rabbit; Mouse-Reactive; MyBioSource
Brand: MyBioSource
SKU: MBS840198
Price: 215 USD
Availability: InStock
Rating: 5 (10 reviews)

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS840198

Background: Apoptosis can be induced by certain cytokines including TNF and Fas Ligand of the TNF super-family thromugh their death domain (DD) containing receptors, TNFR1 and Fas. A member of the TNF receptor family was recently identified and designated DR4… More details

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Product Documentation

Sample Manual Insert View PDF

Testing Data View PDF

Certificate of Analysis (COA) View PDF

QC Report View PDF

Material Safety Data Sheet View PDF

Technical Datasheet View PDF

Protocol View PDF

Product Overview

Product Name

DR4, Polyclonal Antibody

Full Product Name

DR4 Antibody

Product Gene Name

anti-DR4 antibody

Product Synonym Names

TNFRSF10A; TRAILR1; MGC9365; APO2; CD261; TRAIL-R1; TRAILR-1

Clonality

Polyclonal

Isotype

IgG

Host

Rabbit

Species Reactivity

Mouse

Form/Format

100 ug (0.5 mg/ml) affinity purified rabbit anti-DR4 polyclonal antibody in phosphate buffered saline (PBS), pH 7.2, containing 30% glycerol, 0.5% BSA, 0.01% thimerosal.
Appearance: Colorless liquid

Purity/Purification

Affinity purified

Concentration

0.5 mg/ml (lot specific)

Preparation and Storage

At -20 degree C
Shelf Life: 12 months

Molecular Weight

50,089 Da

OMIM

603611

3D Structure

ModBase 3D Structure for O00220

Immunogen

Synthetic peptide corresponding to residues surrounding amino acids 454 of human DR4

Handling

The antibody solution should be gently mixed before use.

Applications Tested/Suitable for anti-DR4 antibody

Western Blot (WB)

Application Notes for anti-DR4 antibody

Western blot analysis (0.5-4 ug/ml) and immunofluorescence. However, the optimal conditions should be determined individually. The antibody detects a 57 kDa mouse DR4 in Western blot analysis.

Other Notes

Small volumes of anti-DR4 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for DR4 purchase

MBS840198 is an antibody targeting DR4. Also known as DR4 Antibody. Reactive in Mouse. Host: Rabbit.

Additional Details

NCBI/Uniprot data below describe general gene information for DR4. It may not necessarily be applicable to this product.

NCBI GI #

259906438

NCBI GeneID

8797

NCBI Accession #

NP_003835.3

UniProt Primary Accession #

O00220

UniProt Secondary Accession #

Q53Y72; Q96E62; A8K5I4

UniProt Related Accession #

O00220

GenBank Nucleotide #

NM_003844.3

NCBI Official Full Name

tumor necrosis factor receptor superfamily member 10A

NCBI Official Synonym Full Names

tumor necrosis factor receptor superfamily, member 10a

NCBI Official Symbol

TNFRSF10A

NCBI Official Synonym Symbols

DR4; APO2; CD261; TRAILR1; TRAILR-1

UniProt Protein Name

Tumor necrosis factor receptor superfamily member 10A

UniProt Synonym Protein Names

Death receptor 4; TNF-related apoptosis-inducing ligand receptor 1; TRAIL receptor 1; TRAIL-R1; CD_antigen: CD261

Protein Family

Transposon Ty1-DR4 Gag polyprotein

UniProt Gene Name

TNFRSF10A

UniProt Synonym Gene Names

APO2; DR4; TRAILR1; TRAIL receptor 1; TRAIL-R1

UniProt Entry Name

TR10A_HUMAN

NCBI Protein Information

tumor necrosis factor receptor superfamily member 10A

NCBI Summary for DR4

The protein encoded by this gene is a member of the TNF-receptor superfamily. This receptor is activated by tumor necrosis factor-related apoptosis inducing ligand (TNFSF10/TRAIL), and thus transduces cell death signal and induces cell apoptosis. Studies with FADD-deficient mice suggested that FADD, a death domain containing adaptor protein, is required for the apoptosis mediated by this protein. [provided by RefSeq, Jul 2008]

UniProt Comments for DR4

TRAIL-R1: Receptor for the cytotoxic ligand TNFSF10/TRAIL. The adapter molecule FADD recruits caspase-8 to the activated receptor. The resulting death-inducing signaling complex (DISC) performs caspase-8 proteolytic activation which initiates the subsequent cascade of caspases (aspartate-specific cysteine proteases) mediating apoptosis. Promotes the activation of NF- kappa-B.

Protein type: Membrane protein, integral

Chromosomal Location of Human Ortholog: 8p21

Cellular Component: integral to membrane; plasma membrane

Molecular Function: protein binding; protease binding; death receptor activity; TRAIL binding; receptor activity; transcription factor binding

Biological Process: caspase activation; induction of apoptosis via death domain receptors; apoptosis; activation of NF-kappaB-inducing kinase; signal transduction

Research Articles on DR4

1. findings highlight novel mechanisms underlying endoplasmic reticulum stress-induced TNFRSF10A and TNFRSF10B expressions and apoptosis.

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Products associated with anti-DR4 antibody

Reference Product	PubMed Publications
TNFRSF10B antibody	>584 publications with DR4 and TNFRSF10B
TNFSF10 antibody	>575 publications with DR4 and TNFSF10
CASP8 antibody	>192 publications with DR4 and CASP8
FADD antibody	>108 publications with DR4 and FADD
CFLAR antibody	>49 publications with DR4 and CFLAR
TRADD antibody	>20 publications with DR4 and TRADD
CASP10 antibody	>12 publications with DR4 and CASP10
RIPK1 antibody	>8 publications with DR4 and RIPK1
TRAF2 antibody	>7 publications with DR4 and TRAF2
TP53 antibody	>7 publications with DR4 and TP53

Pathways associated with anti-DR4 antibody

Products by Pathway	Pathway Diagram
Apoptosis Pathway antibodies	Apoptosis Pathway Diagram
Apoptosis Pathway antibodies	Apoptosis Pathway Diagram
Apoptosis Pathway antibodies	Apoptosis Pathway Diagram
Apoptosis Modulation And Signaling Pathway antibodies	Apoptosis Modulation And Signaling Pathway Diagram
CASP8 Activity Is Inhibited Pathway antibodies	CASP8 Activity Is Inhibited Pathway Diagram
Caspase Activation Via Extrinsic Apoptotic Signalig Pathway antibodies	Caspase Activation Via Extrinsic Apoptotic Signalig Pathway Diagram
Cytokine-cytokine Receptor Interaction Pathway antibodies	Cytokine-cytokine Receptor Interaction Pathway Diagram
Cytokine-cytokine Receptor Interaction Pathway antibodies	Cytokine-cytokine Receptor Interaction Pathway Diagram
Death Receptor Signalling Pathway antibodies	Death Receptor Signalling Pathway Diagram
Dimerization Of Procaspase-8 Pathway antibodies	Dimerization Of Procaspase-8 Pathway Diagram

Diseases associated with anti-DR4 antibody

Disease Name	Pubmed Publications
Necrosis Antibodies	>522 publications with DR4 and Necrosis
Adenocarcinoma Antibodies	>68 publications with DR4 and Adenocarcinoma
Leukemia Antibodies	>60 publications with DR4 and Leukemia
Lung Neoplasms Antibodies	>37 publications with DR4 and Lung Neoplasms
Breast Neoplasms Antibodies	>34 publications with DR4 and Breast Neoplasms
Prostatic Neoplasms Antibodies	>32 publications with DR4 and Prostatic Neoplasms
Neoplasms, Experimental Antibodies	>31 publications with DR4 and Neoplasms, Experimental
Colonic Neoplasms Antibodies	>25 publications with DR4 and Colonic Neoplasms
Carcinoma, Hepatocellular Antibodies	>22 publications with DR4 and Carcinoma, Hepatocellular
Carcinoma, Non-Small-Cell Lung Antibodies	>21 publications with DR4 and Carcinoma, Non-Small-Cell Lung

Organs/Tissues associated with anti-DR4 antibody

Organ/Tissue Name	Pubmed Publications
Lung Antibodies	>46 publications with DR4 and Lung
Liver Antibodies	>38 publications with DR4 and Liver
Prostate Antibodies	>31 publications with DR4 and Prostate
Brain Antibodies	>17 publications with DR4 and Brain
Vascular Antibodies	>15 publications with DR4 and Vascular
Kidney Antibodies	>15 publications with DR4 and Kidney
Skin Antibodies	>14 publications with DR4 and Skin
Stomach Antibodies	>11 publications with DR4 and Stomach
Muscle Antibodies	>10 publications with DR4 and Muscle
Pancreas Antibodies	>8 publications with DR4 and Pancreas