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BCL-3 Antibody – Rabbit Polyclonal

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS840236

Background: Bcl-3, a proto-oncogene, is believed to be involved in certain human B cell leukemias. It encodes a protein that functions as an IkB-like molecule for native NFkB, but is specific for the p50 subunit of NFkB. More details

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Product Documentation
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Sample Manual Insert View PDF
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Testing Data View PDF
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Material Safety Data Sheet View PDF
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Technical Datasheet View PDF
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Protocol View PDF

Product Overview

Product Name
Bcl-3, Polyclonal Antibody
Full Product Name
Bcl-3 Antibody
Product Gene Name
anti-Bcl-3 antibody
Product Synonym Names
BCL3; D19S37; BCL4
Clonality
Polyclonal
Isotype
IgG
Host
Rabbit
Species Reactivity
Human, Mouse, Rat
Form/Format
100 ug (0.2 mg/ml) Protein G affinity purified rabbit anti-Bcl-3 polyclonal antibody in phosphate buffered saline (PBS), pH 7.2, containing 30% glycerol, 0.5% BSA, 0.01% thimerosal.
Appearance: Colorless liquid
Purity/Purification
Affinity purified
Concentration
0.2 mg/ml (lot specific)
Preparation and Storage
At -20 degree C
Shelf Life: 12 months
Molecular Weight
47,584 Da
OMIM
109560
3D Structure
ModBase 3D Structure for P20749
Immunogen
Synthetic peptide surrounding amino acid 424 of human Bcl-3
Handling
The antibody solution should be gently mixed before use.
Applications Tested/Suitable for anti-Bcl-3 antibody
Western Blot (WB), Immunoprecipitation (IP), Immunofluorescence (IF), Immunohistochemistry (IHC)
Application Notes for anti-Bcl-3 antibody
Western blot analysis (2-4 ug/ml). Per researchers feedback, the antibody also works well in Immunoprecipation (10-20 ug/ml), and Immunohistochemistry (20-40 ug/ml). However, the optimal conditions should be determined individually. Detects 55-60 kDa Bcl-3 of human, mouse, and rat origins. Other species have not been tested.

Testing Data of anti-Bcl-3 antibody

Rabbit Anti-BCL-3 Polyclonal Antibody – Cat# MBS840236

Other Notes

Small volumes of anti-Bcl-3 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for Bcl-3 purchase

MBS840236 is an antibody targeting Bcl-3. Also known as Bcl-3 Antibody. Reactive in Human, Mouse, Rat. Host: Rabbit.

Additional Details

NCBI/Uniprot data below describe general gene information for Bcl-3. It may not necessarily be applicable to this product.

NCBI GI #
164664508
NCBI GeneID
602
NCBI Accession #
NP_005169.2
UniProt Primary Accession #
P20749
UniProt Related Accession #
P20749
GenBank Nucleotide #
NM_005178.4
NCBI Official Full Name
B-cell lymphoma 3 protein
NCBI Official Synonym Full Names
B-cell CLL/lymphoma 3
NCBI Official Symbol
BCL3
NCBI Official Synonym Symbols
BCL4; D19S37
UniProt Protein Name
B-cell lymphoma 3 protein
UniProt Synonym Protein Names
Proto-oncogene BCL3
Protein Family
B-cell lymphoma 3 protein
UniProt Gene Name
BCL3
UniProt Synonym Gene Names
BCL4; D19S37; BCL-3
UniProt Entry Name
BCL3_HUMAN
NCBI Protein Information
B-cell lymphoma 3 protein

NCBI Summary for Bcl-3

This gene is a proto-oncogene candidate. It is identified by its translocation into the immunoglobulin alpha-locus in some cases of B-cell leukemia. The protein encoded by this gene contains seven ankyrin repeats, which are most closely related to those found in I kappa B proteins. This protein functions as a transcriptional co-activator that activates through its association with NF-kappa B homodimers. The expression of this gene can be induced by NF-kappa B, which forms a part of the autoregulatory loop that controls the nuclear residence of p50 NF-kappa B. [provided by RefSeq, Jul 2008]
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UniProt Comments for Bcl-3

Contributes to the regulation of transcriptional activation of NF-kappa-B target genes. In the cytoplasm, inhibits the nuclear translocation of the NF-kappa-B p50 subunit. In the nucleus, acts as transcriptional activator that promotes transcription of NF-kappa-B target genes. Contributes to the regulation of cell proliferation ().
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Research Articles on Bcl-3

1. a delayed (incoherent) feed-forward loop together with differential rates of TNFA (fast) and BCL3 (slow) mRNA turnover provide robust, pulsatile expression of TNFalpha

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Products associated with anti-Bcl-3 antibody

 Reference Product  PubMed Publications
 JUN antibody  >27 publications with Bcl-3 and JUN
 NFKB2 antibody  >12 publications with Bcl-3 and NFKB2
 STAT3 antibody  >8 publications with Bcl-3 and STAT3
 RELB antibody  >8 publications with Bcl-3 and RELB
 RELA antibody  >6 publications with Bcl-3 and RELA
 NFKB1 antibody  >6 publications with Bcl-3 and NFKB1
 CYLD antibody  >5 publications with Bcl-3 and CYLD
 CTBP1 antibody  >1 publications with Bcl-3 and CTBP1

Pathways associated with anti-Bcl-3 antibody

 Products by Pathway  Pathway Diagram
 Atypical NF-kappaB Pathway antibodies  Atypical NF-kappaB Pathway Diagram
 TNF Signaling Pathway antibodies  TNF Signaling Pathway Diagram
 TNF Signaling Pathway antibodies  TNF Signaling Pathway Diagram
 TNF-alpha/NF-kB Signaling Pathway antibodies  TNF-alpha/NF-kB Signaling Pathway Diagram

Diseases associated with anti-Bcl-3 antibody

 Disease Name  Pubmed Publications
 Chromosome Aberrations Antibodies  >44 publications with Bcl-3 and Chromosome Aberrations
 Inflammation Antibodies  >14 publications with Bcl-3 and Inflammation
 Necrosis Antibodies  >13 publications with Bcl-3 and Necrosis
 Nervous System Diseases Antibodies  >11 publications with Bcl-3 and Nervous System Diseases
 Cardiovascular Diseases Antibodies  >7 publications with Bcl-3 and Cardiovascular Diseases
 Neoplasms, Experimental Antibodies  >6 publications with Bcl-3 and Neoplasms, Experimental
 Disease Models, Animal Antibodies  >6 publications with Bcl-3 and Disease Models, Animal
 Breast Neoplasms Antibodies  >5 publications with Bcl-3 and Breast Neoplasms
 Cell Transformation, Neoplastic Antibodies  >4 publications with Bcl-3 and Cell Transformation, Neoplastic
 Ovarian Neoplasms Antibodies  >3 publications with Bcl-3 and Ovarian Neoplasms

Organs/Tissues associated with anti-Bcl-3 antibody

 Organ/Tissue Name  Pubmed Publications
 Blood Antibodies  >35 publications with Bcl-3 and Blood
 Bone Antibodies  >11 publications with Bcl-3 and Bone
 Brain Antibodies  >8 publications with Bcl-3 and Brain
 Liver Antibodies  >8 publications with Bcl-3 and Liver
 Kidney Antibodies  >6 publications with Bcl-3 and Kidney
 Skin Antibodies  >5 publications with Bcl-3 and Skin
 Spleen Antibodies  >4 publications with Bcl-3 and Spleen
 Lymph Node Antibodies  >4 publications with Bcl-3 and Lymph Node
 Placenta Antibodies  >3 publications with Bcl-3 and Placenta
 Thyroid Antibodies  >3 publications with Bcl-3 and Thyroid
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