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PHC2 Antibody – Rabbit Polyclonal

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS840259

Polyclonal Antibody to detect PHC2 in mouse samples. Background: PHC2 is a component of a Polycomb group (PcG) multiprotein PRC1-like complex, a complex class required to maintain the transcriptionally repressive state of many genes, including Hox genes,… More details

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Sample Manual Insert View PDF
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Testing Data View PDF
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Material Safety Data Sheet View PDF
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Technical Datasheet View PDF
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Protocol View PDF

Product Overview

Product Name
PHC2, Polyclonal Antibody
Full Product Name
PHC2 polyclonal antibody
Product Gene Name
Product Synonym Names
EDR2; HPH2; PH2
Clonality
Polyclonal
Isotype
IgG
Host
Rabbit
Species Reactivity
Mouse
Form/Format
In PBS with 0.05% (W/V) sodium azide.
Appearance: Colorless liquid
Preparation and Storage
At -20 degree C
Shelf Life: 12 months
Molecular Weight
90,812 Da
OMIM
602979
3D Structure
ModBase 3D Structure for Q8IXK0
Immunogen
Polyclonal antibody raised in rabbit against mouse PHC2 (polyhomeotic homolog 2) using two KLH-conjugated synthetic peptides containing a sequence from the central region of the protein.
Positive Control
ELISA: Peptides.
Handling
The antibody solution should be gently mixed before use.
Applications Tested/Suitable for anti-PHC2 antibody
ELISA (EIA)
Application Notes for anti-PHC2 antibody
ELISA: 1:500.

Testing Data of anti-PHC2 antibody

Rabbit Anti-PHC2 Polyclonal Antibody – Cat# MBS840259

Other Notes

Small volumes of anti-PHC2 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for PHC2 purchase

MBS840259 is an antibody targeting PHC2. Also known as PHC2 polyclonal antibody. Reactive in Mouse. Host: Rabbit.

Additional Details

NCBI/Uniprot data below describe general gene information for PHC2. It may not necessarily be applicable to this product.

NCBI GI #
NCBI GeneID
NCBI Accession #
UniProt Primary Accession #
UniProt Secondary Accession #
UniProt Related Accession #
GenBank Nucleotide #
NCBI Official Full Name
polyhomeotic-like protein 2 isoform b
NCBI Official Synonym Full Names
polyhomeotic homolog 2 (Drosophila)
NCBI Official Symbol
PHC2
NCBI Official Synonym Symbols
PH2; EDR2; HPH2
UniProt Protein Name
Polyhomeotic-like protein 2
UniProt Synonym Protein Names
Early development regulatory protein 2
UniProt Gene Name
PHC2
UniProt Synonym Gene Names
EDR2; PH2; hPH2
UniProt Entry Name
PHC2_HUMAN
NCBI Protein Information
polyhomeotic-like protein 2

NCBI Summary for PHC2

In Drosophila melanogaster, the 'Polycomb' group (PcG) of genes are part of a cellular memory system that is responsible for the stable inheritance of gene activity. PcG proteins form a large multimeric, chromatin-associated protein complex. The protein encoded by this gene has homology to the Drosophila PcG protein 'polyhomeotic' (Ph) and is known to heterodimerize with EDR1 and colocalize with BMI1 in interphase nuclei of human cells. The specific function in human cells has not yet been determined. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]
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UniProt Comments for PHC2

PHC2: Component of a Polycomb group (PcG) multiprotein PRC1- like complex, a complex class required to maintain the transcriptionally repressive state of many genes, including Hox genes, throughout development. PcG PRC1 complex acts via chromatin remodeling and modification of histones; it mediates monoubiquitination of histone H2A 'Lys-119', rendering chromatin heritably changed in its expressibility. 5 isoforms of the human protein are produced by alternative splicing.

Protein type: Transcription, coactivator/corepressor

Chromosomal Location of Human Ortholog: 1p34.3

Cellular Component: nucleoplasm; heterochromatin; PcG protein complex; nucleus

Molecular Function: protein binding; DNA binding; zinc ion binding

Biological Process: multicellular organismal development; spermatogenesis
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Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

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