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DAP12 Antibody – Rabbit Polyclonal

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS840274

Background: DAP12 (KARAP) is a natural killer (NK) cell-expressed cell surface receptor and belongs to the immunoglobulin and C-type lectin superfamily. Unlike other members of this family which possess immunoreceptor tyrosine-based inhibitory motifs (ITIM),… More details

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Product Overview

Product Name
DAP12, Polyclonal Antibody
Full Product Name
DAP12 Antibody
Product Gene Name
anti-DAP12 antibody
Product Synonym Names
DAP-12; DAP 12; DAP12; TYRO protein tyrosine kinase binding protein; TYROBP
Clonality
Polyclonal
Isotype
IgG
Host
Rabbit
Species Reactivity
Human
Form/Format
100 ug (0.5 mg/ml) affinity purified rabbit anti-DAP12 polyclonal antibody in phosphate buffered saline (PBS), pH 7.2, containing 30% glycerol, 0.5% BSA, 0.01% thimerosal.
Appearance: Colorless liquid
Purity/Purification
Affinity purified
Concentration
0.5 mg/ml (lot specific)
Preparation and Storage
At -20 degree C
Shelf Life: 12 months
Molecular Weight
12,367 Da
3D Structure
ModBase 3D Structure for O54885
Immunogen
Synthetic peptide corresponding to residues surrounding amino acids 94 of mouse DAP-12
Handling
The antibody solution should be gently mixed before use.
Applications Tested/Suitable for anti-DAP12 antibody
Western Blot (WB)
Application Notes for anti-DAP12 antibody
Western blot analysis (0.5-4 ug/ml). However, the optimal conditions should be determined individually.

Testing Data of anti-DAP12 antibody

Rabbit Anti-DAP12 Polyclonal Antibody – Cat# MBS840274

Other Notes

Small volumes of anti-DAP12 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for DAP12 purchase

MBS840274 is an antibody targeting DAP12. Also known as DAP12 Antibody. Reactive in Human. Host: Rabbit.

Additional Details

NCBI/Uniprot data below describe general gene information for DAP12. It may not necessarily be applicable to this product.

NCBI GI #
6755915
NCBI GeneID
22177
NCBI Accession #
NP_035792.1
UniProt Primary Accession #
O54885
UniProt Secondary Accession #
O88603
UniProt Related Accession #
O54885
GenBank Nucleotide #
NM_011662.2
NCBI Official Full Name
TYRO protein tyrosine kinase-binding protein
NCBI Official Synonym Full Names
TYRO protein tyrosine kinase binding protein
NCBI Official Symbol
Tyrobp
NCBI Official Synonym Symbols
Ly83; DAP12; KARAP
UniProt Protein Name
TYRO protein tyrosine kinase-binding protein
UniProt Synonym Protein Names
DNAX-activation protein 12; Killer-activating receptor-associated protein; KAR-associated protein
Protein Family
C-type lectin domain family
UniProt Gene Name
Tyrobp
UniProt Synonym Gene Names
Dap12; Karap; KAR-associated protein
UniProt Entry Name
TYOBP_MOUSE
NCBI Protein Information
TYRO protein tyrosine kinase-binding protein

UniProt Comments for DAP12

TYROBP: Non-covalently associates with activating receptors of the CD300 family. Cross-linking of CD300-TYROBP complexes results in cellular activation. Involved for instance in neutrophil activation mediated by integrin. Defects in TYROBP are a cause of polycystic lipomembranous osteodysplasia with sclerosing leukoencephalopathy (PLOSL); also called presenile dementia with bone cysts or Nasu-Hakola disease (NHD). PLOSL is a recessively inherited disease characterized by a combination of psychotic symptoms rapidly progressing to presenile dementia and bone cysts restricted to wrists and ankles. PLOSL has a global distribution, although most of the patients have been diagnosed in Finland and Japan, with an estimated population prevalence of 2x10(-6) in the Finns. Belongs to the TYROBP family. 2 isoforms of the human protein are produced by alternative splicing.

Protein type: Membrane protein, integral; Cell surface

Cellular Component: cell surface; membrane; integral to membrane

Molecular Function: identical protein binding; protein binding; receptor binding

Biological Process: integrin-mediated signaling pathway; neutrophil activation during immune response; macrophage activation during immune response
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Research Articles on DAP12

1. a previously unrecognized role for DAP12 expression in tissue-resident alveolar macrophages in mediating acute noninfectious tissue injury through regulation of neutrophil trafficking.

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Products associated with anti-DAP12 antibody

 Reference Product  PubMed Publications
 Trem2 antibody  >55 publications with DAP12 and Trem2
 Syk antibody  >36 publications with DAP12 and Syk
 Clec5a antibody  >13 publications with DAP12 and Clec5a
 Klrk1 antibody  >12 publications with DAP12 and Klrk1
 Klra4 antibody  >9 publications with DAP12 and Klra4
 Klrd1 antibody  >7 publications with DAP12 and Klrd1
 Sirpa antibody  >1 publications with DAP12 and Sirpa
 Cd300lb antibody  >1 publications with DAP12 and Cd300lb

Pathways associated with anti-DAP12 antibody

 Products by Pathway  Pathway Diagram
 Axon Guidance Pathway antibodies  Axon Guidance Pathway Diagram
 Cell-Cell Communication Pathway antibodies  Cell-Cell Communication Pathway Diagram
 DAP12 Interactions Pathway antibodies  DAP12 Interactions Pathway Diagram
 DAP12 Signaling Pathway antibodies  DAP12 Signaling Pathway Diagram
 Developmental Biology Pathway antibodies  Developmental Biology Pathway Diagram
 Immune System Pathway antibodies  Immune System Pathway Diagram
 Innate Immune System Pathway antibodies  Innate Immune System Pathway Diagram
 Natural Killer Cell Mediated Cytotoxicity Pathway antibodies  Natural Killer Cell Mediated Cytotoxicity Pathway Diagram
 Natural Killer Cell Mediated Cytotoxicity Pathway antibodies  Natural Killer Cell Mediated Cytotoxicity Pathway Diagram
 Osteoclast Differentiation Pathway antibodies  Osteoclast Differentiation Pathway Diagram

Diseases associated with anti-DAP12 antibody

 Disease Name  Pubmed Publications
 Inflammation Antibodies  >47 publications with DAP12 and Inflammation
 Necrosis Antibodies  >21 publications with DAP12 and Necrosis
 Polycystic lipomembranous osteodysplasia with sclerosing leukoencephalopathy Antibodies  >20 publications with DAP12 and Polycystic lipomembranous osteodysplasia with sclerosing leukoencephalopathy
 Disease Models, Animal Antibodies  >15 publications with DAP12 and Disease Models, Animal
 Lung Diseases Antibodies  >11 publications with DAP12 and Lung Diseases
 Neoplasms, Experimental Antibodies  >7 publications with DAP12 and Neoplasms, Experimental
 Vascular Diseases Antibodies  >6 publications with DAP12 and Vascular Diseases
 Liver Diseases Antibodies  >5 publications with DAP12 and Liver Diseases
 Fibrosis Antibodies  >3 publications with DAP12 and Fibrosis
 Lung Neoplasms Antibodies  >3 publications with DAP12 and Lung Neoplasms

Organs/Tissues associated with anti-DAP12 antibody

 Organ/Tissue Name  Pubmed Publications
 Blood Antibodies  >149 publications with DAP12 and Blood
 Bone Antibodies  >78 publications with DAP12 and Bone
 Brain Antibodies  >37 publications with DAP12 and Brain
 Bone Marrow Antibodies  >29 publications with DAP12 and Bone Marrow
 Spleen Antibodies  >18 publications with DAP12 and Spleen
 Lymph Node Antibodies  >7 publications with DAP12 and Lymph Node
 Skin Antibodies  >3 publications with DAP12 and Skin
 Intestine Antibodies  >2 publications with DAP12 and Intestine
 Embryonic Tissue Antibodies  >2 publications with DAP12 and Embryonic Tissue
 Eye Antibodies  >2 publications with DAP12 and Eye
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