HNF-4 Antibody – Rabbit Polyclonal

The protein encoded by this gene is a transcription factor involved in the development of the pancreas, liver, kidney, and intestines. The encoded protein also functions to maintain glucose homeostasis. Several transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Aug 2015]

HNF4 alpha: a nuclear transcription factor which binds DNA as a homodimer. Controls the expression of several genes, including hepatocyte nuclear factor 1 alpha, a transcription factor which regulates the expression of several hepatic gene, alpha 1-antitrypsin, apolipoprotein CIII, and transthyretin genes. May be essential for development of the liver, kidney and intestine. Mutations have been associated with monogenic autosomal dominant non-insulin-dependent diabetes mellitus type I. Four alternatively spliced isoforms have been described.

Protein type: DNA-binding; Nuclear receptor; Transcription factor

Cellular Component: transcription factor complex; cytoplasm; nucleus

Molecular Function: RNA polymerase II transcription factor activity, enhancer binding; ligand-dependent nuclear receptor activity; protein homodimerization activity; acyl-CoA binding; zinc ion binding; metal ion binding; transcription factor binding; protein binding; DNA binding; sequence-specific DNA binding; steroid hormone receptor activity; fatty acid binding; transcription factor activity; palmitoyl-CoA hydrolase activity; receptor binding

Biological Process: transcription from RNA polymerase II promoter; acyl-CoA metabolic process; regulation of lipid metabolic process; positive regulation of transcription, DNA-dependent; lipid homeostasis; negative regulation of tyrosine phosphorylation of Stat5 protein; glucose homeostasis; positive regulation of gluconeogenesis; negative regulation of cell proliferation; negative regulation of protein import into nucleus, translocation; regulation of transcription, DNA-dependent; regulation of gastrulation; response to glucose stimulus; negative regulation of mitotic cell cycle; cell differentiation; regulation of microvillus biogenesis; phospholipid homeostasis; intercellular junction assembly and maintenance; positive regulation of fatty acid biosynthetic process; transcription, DNA-dependent; establishment of tissue polarity; negative regulation of transcription factor activity; regulation of transcription from RNA polymerase II promoter; xenobiotic metabolic process; ornithine metabolic process; positive regulation of transcription from RNA polymerase II promoter; steroid hormone mediated signaling; lipid metabolic process; negative regulation of cell growth; blood coagulation; sex differentiation; regulation of insulin secretion