STAT5 Antibody – Rabbit Polyclonal

STAT5A: transcription factor of the STAT family. Phosphorylated and activated by receptor-associated kinases downstream of many cytokines and growth-factor receptors. Activation of this protein in myeloma and lymphoma associated with a TEL/JAK2 fusion protein is essential for the tumorigenesis. Induces the expression of BCL2L1/BCL-X(L) in the mouse, suggesting an antiapoptotic function of this protein. Forms homo- or heterodimers that translocate into the nucleus where they regulate transcription. Two alternatively spliced isoforms have been described.

Protein type: Motility/polarity/chemotaxis; Oncoprotein; Transcription factor; DNA-binding

Cellular Component: cytoplasm; nucleus

Molecular Function: signal transducer activity; protein binding; DNA binding; sequence-specific DNA binding; double-stranded DNA binding; transcription factor activity; protein phosphatase binding

Biological Process: mammary gland involution; positive regulation of interleukin-2 biosynthetic process; T cell differentiation in the thymus; female pregnancy; positive regulation of multicellular organism growth; 2-oxoglutarate metabolic process; sequestering of lipid; natural killer cell differentiation; allantoin metabolic process; negative regulation of mast cell apoptosis; regulation of steroid metabolic process; T cell homeostasis; Peyer's patch development; isoleucine metabolic process; transcription, DNA-dependent; valine metabolic process; development of secondary female sexual characteristics; JAK-STAT cascade; regulation of transcription from RNA polymerase II promoter; regulation of epithelial cell differentiation; positive regulation of transcription from RNA polymerase II promoter; taurine metabolic process; negative regulation of apoptosis; lactation; transcription from RNA polymerase II promoter; succinate metabolic process; response to peptide hormone stimulus; oxaloacetate metabolic process; peptidyl-tyrosine phosphorylation; fatty acid metabolic process; signal transduction; positive regulation of activated T cell proliferation; positive regulation of mitotic cell cycle; positive regulation of natural killer cell differentiation; mammary gland development; regulation of transcription, DNA-dependent; luteinization; positive regulation of cell proliferation; development of secondary male sexual characteristics; creatinine metabolic process; positive regulation of gamma-delta T cell differentiation; regulation of cell adhesion; negative regulation of erythrocyte differentiation; cytokine and chemokine mediated signaling pathway; citrate metabolic process; regulation of multicellular organism growth; positive regulation of natural killer cell mediated cytotoxicity; creatine metabolic process; positive regulation of lymphocyte differentiation; positive regulation of B cell differentiation; positive regulation of inflammatory response