Rabbit Anti-HDC Polyclonal Antibody – Cat# MBS840299

HDC Antibody – Rabbit Polyclonal

Name: HDC Antibody; Polyclonal; Rabbit; Human/Mouse/Rat-Reactive; MyBioSource
Brand: MyBioSource
SKU: MBS840299
Price: 215 USD
Availability: InStock
Rating: 5 (10 reviews)

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS840299

Background: Histidine decarboxylase (HDC) is the enzyme catalyzing the conversion of histidine into histamine. HDC can be found in the histamine secreting ECL cells of some species as well as in the mast cells. More details

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Product Documentation

Sample Manual Insert View PDF

Testing Data View PDF

Certificate of Analysis (COA) View PDF

QC Report View PDF

Material Safety Data Sheet View PDF

Technical Datasheet View PDF

Protocol View PDF

Product Overview

Product Name

HDC, Polyclonal Antibody

Full Product Name

HDC Antibody

Product Gene Name

anti-HDC antibody

Product Synonym Names

Histidine decarboxylase

Clonality

Polyclonal

Isotype

IgG

Host

Rabbit

Species Reactivity

Human, Mouse, Rat

Form/Format

100 ug (0.2 mg/ml) protein A affinity purified rabbit polyclonal antibody in phosphate-buffered saline (PBS) containing 30% glycerol, 0.5% BSA, and 0.01% thimerosal.
Appearance: Colorless liquid

Purity/Purification

Affinity purified

Concentration

0.2 mg/ml (lot specific)

Preparation and Storage

At -20 degree C
Shelf Life: 12 months

Molecular Weight

70,059 Da

OMIM

142704

Immunogen

Synthetic peptide surrounding amino acid 22 of human HDC

Handling

The antibody solution should be gently mixed before use.

Applications Tested/Suitable for anti-HDC antibody

Western Blot (WB)

Application Notes for anti-HDC antibody

Western blotting (0.5-4 ug/ml). The optimal concentrations should be determined individually. The antibody detects the 73 kDa full length HDC in samples from human, mouse and rat origins. It does not cross react with DOPA decarboxylase (DDC).

Other Notes

Small volumes of anti-HDC antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for HDC purchase

MBS840299 is an antibody targeting HDC. Also known as HDC Antibody. Reactive in Human, Mouse, Rat. Host: Rabbit.

Additional Details

NCBI/Uniprot data below describe general gene information for HDC. It may not necessarily be applicable to this product.

NCBI GI #

219518162

NCBI GeneID

3067

NCBI Accession #

AAI44174

UniProt Secondary Accession #

A1L4G0; B7ZM01

UniProt Related Accession #

P19113

NCBI Official Full Name

HDC protein

NCBI Official Synonym Full Names

histidine decarboxylase

NCBI Official Symbol

HDC

UniProt Protein Name

Histidine decarboxylase

Protein Family

Headcase protein

UniProt Gene Name

HDC

UniProt Synonym Gene Names

HDC

UniProt Entry Name

DCHS_HUMAN

NCBI Protein Information

histidine decarboxylase

NCBI Summary for HDC

This gene encodes a member of the group II decarboxylase family and forms a homodimer that converts L-histidine to histamine in a pyridoxal phosphate dependent manner. Histamine regulates several physiologic processes, including neurotransmission, gastric acid secretion,inflamation, and smooth muscle tone.[provided by RefSeq, Aug 2010]

UniProt Comments for HDC

HDC: a member of the group II decarboxylase family and forms a homodimer that converts L-histidine to histamine in a pyridoxal phosphate dependent manner. Histamine regulates several physiologic processes, including neurotransmission, gastric acid secretion,inflamation, and smooth muscle tone.[provided by RefSeq, Aug 2010]

Protein type: Amino Acid Metabolism - histidine; EC 4.1.1.22; Lyase

Chromosomal Location of Human Ortholog: 15q21.2

Cellular Component: cytosol

Molecular Function: pyridoxal phosphate binding; histidine decarboxylase activity

Biological Process: histamine biosynthetic process; catecholamine biosynthetic process; histidine metabolic process; histidine catabolic process

Disease: Gilles De La Tourette Syndrome

Research Articles on HDC

1. HDC rs17740607 polymorphism is at least a partial loss-of-function variant and acts as a protective factor against chronic heart failure

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Products associated with anti-HDC antibody

Reference Product	PubMed Publications
HNMT antibody	>9 publications with HDC and HNMT
ABP1 antibody	>3 publications with HDC and ABP1
CNDP2 antibody	>2 publications with HDC and CNDP2

Diseases associated with anti-HDC antibody

Disease Name	Pubmed Publications
Breast Neoplasms Antibodies	>199 publications with HDC and Breast Neoplasms
Inflammation Antibodies	>91 publications with HDC and Inflammation
Brain Diseases Antibodies	>66 publications with HDC and Brain Diseases
Gastrointestinal Diseases Antibodies	>53 publications with HDC and Gastrointestinal Diseases
Necrosis Antibodies	>47 publications with HDC and Necrosis
Neoplasms, Experimental Antibodies	>38 publications with HDC and Neoplasms, Experimental
Liver Diseases Antibodies	>30 publications with HDC and Liver Diseases
Fever Antibodies	>27 publications with HDC and Fever
Nausea Antibodies	>23 publications with HDC and Nausea
Kidney Diseases Antibodies	>21 publications with HDC and Kidney Diseases

Organs/Tissues associated with anti-HDC antibody

Organ/Tissue Name	Pubmed Publications
Bone Marrow Antibodies	>298 publications with HDC and Bone Marrow
Brain Antibodies	>202 publications with HDC and Brain
Stomach Antibodies	>130 publications with HDC and Stomach
Lung Antibodies	>92 publications with HDC and Lung
Spleen Antibodies	>52 publications with HDC and Spleen
Intestine Antibodies	>22 publications with HDC and Intestine
Thymus Antibodies	>9 publications with HDC and Thymus
Testis Antibodies	>8 publications with HDC and Testis
Adipose Tissue Antibodies	>6 publications with HDC and Adipose Tissue
Pancreas Antibodies	>6 publications with HDC and Pancreas