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GRO/Kc (CXCL1) Antibody – Rabbit Polyclonal

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS611087

All three isoforms of GRO are CXC chemokines that can signal through the CXCR1 or CXCR2 receptors. The GRO proteins chemoattract and activate neutrophils and basophils. Recombinant rat GRO/KC is a 7.8kD protein consisting of 72 amino acids including the 'ELR'… More details

$775 / 0.1 mg +1 FREE 8GB USB
Product Documentation
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Sample Manual Insert View PDF
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Testing Data View PDF
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Certificate of Analysis (COA) View PDF
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QC Report View PDF
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Material Safety Data Sheet View PDF
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Technical Datasheet View PDF
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Protocol View PDF

Product Overview

Online Datasheet in PDF
Product Name
GRO/KC (Cxcl1), Polyclonal Antibody
Full Product Name
GRO/KC
Product Gene Name
anti-Cxcl1 antibody
Product Synonym Names
Anti -GRO/KC
Clonality
Polyclonal
Isotype
IgG
Host
Rabbit
Species Reactivity
Rat
Form/Format
Supplied as a liquid in PBS, pH7.2, 40% glycerol.
Purity/Purification
Affinity Purified
Purified by affinity chromatography.
Specificity
Recognizes rat GRO/KC.
Preparation and Storage
May be stored at 4 degree C for short-term only. For long-term storage, aliquot and store at -20 degree C. Aliquots are stable for at least 12 months at -20 degree C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer.
Molecular Weight
10,249 Da
Chromosome Location
Chromosome: 14; NC_005113.3 (18653032..18654811, complement). Location: 14p22
3D Structure
ModBase 3D Structure for P14095
Immunogen
Highly purified (>98%) recombinant antigen.

Product Categories/Family for anti-Cxcl1 antibody

Antibodies; Abs to Growth Factors; Cytokines
Applications Tested/Suitable for anti-Cxcl1 antibody
ELISA (EL/EIA), Western Blot (WB), Neutralization
Application Notes for anti-Cxcl1 antibody
Suitable for use in ELISA, Western Blot and Neutralization.
Dilution: ELISA: 0.5ug/ml (100ul/well).
Western Blot: 0.1-0.2ug/ml. Use 1.5-3.0ng/lane as the detection limit for recombinant rat GRO/KC.
Neutralization: 5-10ug/ml.

Other Notes

Small volumes of anti-Cxcl1 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for Cxcl1 purchase

MBS611087 is an antibody targeting Cxcl1. Also known as GRO/KC. Reactive in Rat. Host: Rabbit.

Additional Details

NCBI/Uniprot data below describe general gene information for Cxcl1. It may not necessarily be applicable to this product.

NCBI GI #
13540652
NCBI GeneID
81503
NCBI Accession #
NP_110472.1
UniProt Primary Accession #
P14095
UniProt Related Accession #
P14095
GenBank Nucleotide #
NM_030845.1
NCBI Official Full Name
growth-regulated alpha protein
NCBI Official Synonym Full Names
chemokine (C-X-C motif) ligand 1
NCBI Official Symbol
Cxcl1
NCBI Official Synonym Symbols
Gro1; CINC-1
UniProt Protein Name
Growth-regulated alpha protein
UniProt Synonym Protein Names
C-X-C motif chemokine 1; Cytokine-induced neutrophil chemoattractant 1; CINC-1; Platelet-derived growth factor-inducible protein KC
Protein Family
Growth-regulated alpha protein
UniProt Gene Name
Cxcl1
UniProt Synonym Gene Names
Cinc1; Gro; Scyb1; CINC-1
UniProt Entry Name
GROA_RAT
NCBI Protein Information
growth-regulated alpha protein; C-X-C motif chemokine 1; cytokine-induced neutrophil chemoattractant 1; platelet-derived growth factor-inducible protein KC; chemokine (C-X-C motif) ligand 1 (melanoma growth stimulating activity, alpha)

NCBI Summary for Cxcl1

acts as a neutrophil chemoattractant; may play a role in acute phase inflammatory response [RGD, Feb 2006]

UniProt Comments for Cxcl1

CXCL2: Produced by activated monocytes and neutrophils and expressed at sites of inflammation. Hematoregulatory chemokine, which, in vitro, suppresses hematopoietic progenitor cell proliferation. GRO-beta(5-73) shows a highly enhanced hematopoietic activity. Belongs to the intercrine alpha (chemokine CxC) family.

Protein type: Motility/polarity/chemotaxis; Secreted, signal peptide; Secreted

Cellular Component: extracellular space

Molecular Function: growth factor activity; chemokine activity; CXCR chemokine receptor binding

Biological Process: neutrophil chemotaxis; response to amphetamine; response to glucocorticoid stimulus; positive regulation of potassium ion transport; response to lipopolysaccharide; positive regulation of leukocyte chemotaxis; response to estradiol stimulus; regulation of cell proliferation; G-protein coupled receptor protein signaling pathway; elevation of cytosolic calcium ion concentration; response to heat; positive regulation of superoxide release; response to molecule of bacterial origin; response to gamma radiation; immune response; acute inflammatory response
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Research Articles on Cxcl1

1. Function of the transient receptor potential vanilloid (TRPV)1 channel is enhanced by dorsal root ganglia inflammation. The effects (decreased tachyphylaxis) are mimicked by incubation with GRO/KC.

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Products associated with anti-Cxcl1 antibody

 Reference Product  PubMed Publications
 Cxcl2 antibody  >486 publications with Cxcl1 and Cxcl2
 Ccl2 antibody  >461 publications with Cxcl1 and Ccl2
 Il8rb antibody  >202 publications with Cxcl1 and Il8rb
 Cxcl3 antibody  >83 publications with Cxcl1 and Cxcl3
 Cxcl6 antibody  >65 publications with Cxcl1 and Cxcl6
 Cxcr4 antibody  >46 publications with Cxcl1 and Cxcr4
 Il6 antibody  >41 publications with Cxcl1 and Il6
 Ccr2 antibody  >36 publications with Cxcl1 and Ccr2
 Cxcr3 antibody  >29 publications with Cxcl1 and Cxcr3
 Ppbp antibody  >21 publications with Cxcl1 and Ppbp

Pathways associated with anti-Cxcl1 antibody

 Products by Pathway  Pathway Diagram
 Chemokine Signaling Pathway antibodies  Chemokine Signaling Pathway Diagram
 Chemokine Signaling Pathway antibodies  Chemokine Signaling Pathway Diagram
 Cytokines And Inflammatory Response (BioCarta) Pathway antibodies  Cytokines And Inflammatory Response (BioCarta) Pathway Diagram
 Legionellosis Pathway antibodies  Legionellosis Pathway Diagram
 Legionellosis Pathway antibodies  Legionellosis Pathway Diagram
 NOD-like Receptor Signaling Pathway antibodies  NOD-like Receptor Signaling Pathway Diagram
 NOD-like Receptor Signaling Pathway antibodies  NOD-like Receptor Signaling Pathway Diagram
 Salmonella Infection Pathway antibodies  Salmonella Infection Pathway Diagram
 Salmonella Infection Pathway antibodies  Salmonella Infection Pathway Diagram
 Spinal Cord Injury Pathway antibodies  Spinal Cord Injury Pathway Diagram

Diseases associated with anti-Cxcl1 antibody

 Disease Name  Pubmed Publications
 Inflammation Antibodies  >958 publications with Cxcl1 and Inflammation
 Necrosis Antibodies  >486 publications with Cxcl1 and Necrosis
 Disease Models, Animal Antibodies  >352 publications with Cxcl1 and Disease Models, Animal
 Lung Diseases Antibodies  >286 publications with Cxcl1 and Lung Diseases
 Neoplasms Antibodies  >282 publications with Cxcl1 and Neoplasms
 Cardiovascular Diseases Antibodies  >163 publications with Cxcl1 and Cardiovascular Diseases
 Lung Injury Antibodies  >156 publications with Cxcl1 and Lung Injury
 Pneumonia Antibodies  >101 publications with Cxcl1 and Pneumonia
 Wounds and Injuries Antibodies  >87 publications with Cxcl1 and Wounds and Injuries
 Reperfusion Injury Antibodies  >84 publications with Cxcl1 and Reperfusion Injury

Organs/Tissues associated with anti-Cxcl1 antibody

 Organ/Tissue Name  Pubmed Publications
 Pancreas Antibodies  >27 publications with Cxcl1 and Pancreas
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