Rabbit Anti-CTSV Polyclonal Antibody – Cat# MBS840367

Cathepsin V (CTSV) Antibody – Rabbit Polyclonal

Name: CTSV Antibody; Polyclonal; Rabbit; Human/Mouse/Rat-Reactive; MyBioSource
Brand: MyBioSource
SKU: MBS840367
Price: 215 USD
Availability: InStock
Rating: 5 (10 reviews)

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS840367

Background: Cathepsin V, also known as Cathepsin L2 and Cathepsin U, is a cysteine protease of the papain family. It is expressed as a proenzyme in lysosomes, which can be autocatalytically converted to the mature form at pH 4.0. Cathepsin V is specifically… More details

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Product Documentation

Sample Manual Insert View PDF

Testing Data View PDF

Certificate of Analysis (COA) View PDF

QC Report View PDF

Material Safety Data Sheet View PDF

Technical Datasheet View PDF

Protocol View PDF

Product Overview

Product Name

Cathepsin V (CTSV), Polyclonal Antibody

Full Product Name

Cathepsin V Antibody

Product Gene Name

anti-CTSV antibody

Product Synonym Names

CATL2; CATL 2; CTSL2; CTSU; CTSV; MGC125957

Clonality

Polyclonal

Isotype

IgG

Host

Rabbit

Species Reactivity

Human, Mouse, Rat

Form/Format

100 ug (0.5 mg/ml) affinity purified rabbit polyclonal cathepsin V antibody in phosphate buffered saline (PBS), pH 7.2, containing 30% glycerol, 0.5% BSA, and 0.01% thimerosal.
Appearance: Colorless liquid

Purity/Purification

Affinity purified

Concentration

0.5 mg/ml (lot specific)

Preparation and Storage

At -20 degree C
Shelf Life: 12 months

Molecular Weight

37,329 Da

OMIM

603308

3D Structure

ModBase 3D Structure for O60911

Immunogen

Synthetic peptide surrounding amino acid 21 of human Cathepsin

Positive Control

Western Blot: Jurkat cell lysate and mouse small intestine lysate. IHC: Kidney tissue

Handling

The antibody solution should be gently mixed before use.

Applications Tested/Suitable for anti-CTSV antibody

Western Blot (WB), Immunohistochemistry (IHC)

Application Notes for anti-CTSV antibody

Western blot analysis (0.5-4 ug/ml) and Immunohistochemistry (5 ug/ml). However, the optimal conditions should be determined individually. Jurkat cell lysate and mouse small intestine tissue lysate can be used as positive controls.

Other Notes

Small volumes of anti-CTSV antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for CTSV purchase

MBS840367 is an antibody targeting CTSV. Also known as Cathepsin V Antibody. Reactive in Human, Mouse, Rat. Host: Rabbit.

Additional Details

NCBI/Uniprot data below describe general gene information for CTSV. It may not necessarily be applicable to this product.

NCBI GI #

320118898

NCBI GeneID

1515

NCBI Accession #

NP_001188504.1

UniProt Primary Accession #

O60911

UniProt Secondary Accession #

O60233; Q2TB86; Q5T1U0

UniProt Related Accession #

O60911

GenBank Nucleotide #

NM_001201575.1

NCBI Official Full Name

cathepsin L2 preproprotein

NCBI Official Synonym Full Names

cathepsin V

NCBI Official Symbol

CTSV

NCBI Official Synonym Symbols

CTSU; CATL2; CTSL2

UniProt Protein Name

Cathepsin L2

UniProt Synonym Protein Names

Cathepsin U; Cathepsin V

Protein Family

Viral cathepsin

UniProt Gene Name

CTSV

UniProt Synonym Gene Names

CATL2; CTSL2; CTSU

UniProt Entry Name

CATL2_HUMAN

NCBI Protein Information

cathepsin L2

NCBI Summary for CTSV

The protein encoded by this gene, a member of the peptidase C1 family, is a lysosomal cysteine proteinase that may play an important role in corneal physiology. This gene is expressed in colorectal and breast carcinomas but not in normal colon, mammary gland, or peritumoral tissues, suggesting a possible role for this gene in tumor processes. Alternatively spliced variants, encoding the same protein, have been identified. [provided by RefSeq, Jan 2011]

UniProt Comments for CTSV

CTSL2: Cysteine protease. May have an important role in corneal physiology. Belongs to the peptidase C1 family.

Protein type: Protease; Secreted, signal peptide; Secreted; EC 3.4.22.15

Chromosomal Location of Human Ortholog: 9q22.2

Cellular Component: extracellular space; lysosomal lumen; neuron projection; microvillus; apical part of cell; extracellular region; nucleolus; perikaryon; external side of plasma membrane; secretory granule

Molecular Function: protein binding; histone binding; cysteine-type endopeptidase activity; protein complex binding; aminopeptidase activity; kininogen binding; cysteine-type carboxypeptidase activity; peptide binding; cysteine-type peptidase activity

Biological Process: extracellular matrix organization and biogenesis; hair follicle morphogenesis; response to glucocorticoid stimulus; Sertoli cell differentiation; multicellular organismal aging; antigen processing and presentation of exogenous peptide antigen via MHC class II; decidualization; cellular response to starvation; proteolysis; extracellular matrix disassembly; protein autoprocessing; autophagic cell death; response to glucose stimulus; spermatogenesis; nerve development

Research Articles on CTSV

1. Expression of cathepsins K, S and V within keratinocytes is reduced in photoprotected skin of aged women.

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Diseases associated with anti-CTSV antibody

Disease Name	Pubmed Publications
Kidney Diseases Antibodies	>1 publications with CTSV and Kidney Diseases
Fibrosis Antibodies	>1 publications with CTSV and Fibrosis

Organs/Tissues associated with anti-CTSV antibody

Organ/Tissue Name	Pubmed Publications
Skin Antibodies	>4 publications with CTSV and Skin
Muscle Antibodies	>1 publications with CTSV and Muscle
Bladder Antibodies	>1 publications with CTSV and Bladder
Pancreas Antibodies	>1 publications with CTSV and Pancreas
Kidney Antibodies	>1 publications with CTSV and Kidney
Thymus Antibodies	>1 publications with CTSV and Thymus