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SMC4/CAPC Antibody – Rabbit Polyclonal

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS840368

Background: The SMC (structural maintenance of chromosomes) family of proteins form heterodimeric complexes that modulate sister chromatid cohesion and chromosome condensation for mitosis. The two distinct classes of SMC protein complexes are comprised of… More details

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Product Overview

Product Name
SMC4/CAPC, Polyclonal Antibody
Full Product Name
SMC4 / CAPC Antibody
Product Gene Name
anti-SMC4/CAPC antibody
Product Synonym Names
CAPC; SMC4; SMC4L1; hCAP-C
Clonality
Polyclonal
Isotype
IgG
Host
Rabbit
Species Reactivity
Human
Form/Format
100 uL affinity purified rabbit polyclonal antibody in phosphate-buffered saline (PBS) containing 30% glycerol, 1% BSA and 0.02% thimerosal.
Appearance: Colorless liquid
Purity/Purification
Affinity purified
Concentration
0.5 mg/ml (lot specific)
Preparation and Storage
At -20 degree C
Shelf Life: 12 months
Molecular Weight
140,278 Da
OMIM
605575
Immunogen
Synthetic peptide of human SMC4
Handling
The antibody solution should be gently mixed before use.
Applications Tested/Suitable for anti-SMC4/CAPC antibody
Western Blot (WB)
Application Notes for anti-SMC4/CAPC antibody
Western blotting (1:200 - 1:2000). However, the optimal concentrations should be determined individually. HEK293T cell lysate can be used as a positive control. The antibody recognizes the SMC4 of human origin. Reactivity to other species has not been tested.

Other Notes

Small volumes of anti-SMC4/CAPC antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for SMC4/CAPC purchase

MBS840368 is an antibody targeting SMC4/CAPC. Also known as SMC4 / CAPC Antibody. Reactive in Human. Host: Rabbit.

Additional Details

NCBI/Uniprot data below describe general gene information for SMC4/CAPC. It may not necessarily be applicable to this product.

NCBI GI #
21361252
NCBI GeneID
10051
NCBI Accession #
NP_005487.2
UniProt Secondary Accession #
O95752; Q8NDL4; Q9UNT9; A6NLT9; D3DNL8
UniProt Related Accession #
Q9NTJ3
GenBank Nucleotide #
NM_005496.2
NCBI Official Full Name
SMC4 structural maintenance of chromosomes 4-like 1; chromosome-associated polypeptide C; structural maintenance of chromosomes (SMC) family member, chromosome-associated protein C; SMC4 (structural maintenance of chromosomes 4, yeast)-like 1
NCBI Official Synonym Full Names
structural maintenance of chromosomes 4
NCBI Official Symbol
SMC4
NCBI Official Synonym Symbols
CAPC; CAP-C; SMC-4; SMC4L1; hCAP-C
UniProt Protein Name
Structural maintenance of chromosomes protein 4
UniProt Synonym Protein Names
Chromosome-associated polypeptide C; hCAP-C; XCAP-C homolog
UniProt Gene Name
SMC4
UniProt Synonym Gene Names
CAPC; SMC4L1; SMC protein 4; SMC-4; hCAP-C
UniProt Entry Name
SMC4_HUMAN
NCBI Protein Information
structural maintenance of chromosomes protein 4

NCBI Summary for SMC4/CAPC

Members of the structural maintenance of chromosomes, or SMC, family (e.g., SMC1A; MIM 300040) are critical for mitotic chromosome condensation in frogs and for DNA repair in mammals.[supplied by OMIM, Nov 2010]

UniProt Comments for SMC4/CAPC

SMC4: Central component of the condensin complex, a complex required for conversion of interphase chromatin into mitotic-like condense chromosomes. The condensin complex probably introduces positive supercoils into relaxed DNA in the presence of type I topoisomerases and converts nicked DNA into positive knotted forms in the presence of type II topoisomerases. Forms an heterodimer with SMC2. Component of the condensin complex, which contains the SMC2 and SMC4 heterodimer, and three non SMC subunits that probably regulate the complex: BRRN1/CAPH, CNAP1/CAPD2 and CAPG. Widely expressed. Higher expression in testis, colon, thymus. Belongs to the SMC family. SMC4 subfamily. 2 isoforms of the human protein are produced by alternative splicing.

Protein type: Cell cycle regulation

Chromosomal Location of Human Ortholog: 3q26.1

Cellular Component: nucleoplasm; cytoplasm; condensin complex; nucleus; cytosol

Molecular Function: protein binding; protein heterodimerization activity; ATP binding

Biological Process: meiotic chromosome condensation; mitotic sister chromatid segregation; mitotic chromosome condensation; cell division; mitotic cell cycle; kinetochore organization and biogenesis; meiotic chromosome segregation
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Research Articles on SMC4/CAPC

1. Knockdown of SMC-4 expression significantly suppressed the proliferation.

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Products associated with anti-SMC4/CAPC antibody

 Reference Product  PubMed Publications
 SMC2 antibody  >30 publications with SMC4/CAPC and SMC2
 CDK1 antibody  >3 publications with SMC4/CAPC and CDK1
 RAD21 antibody  >1 publications with SMC4/CAPC and RAD21

Diseases associated with anti-SMC4/CAPC antibody

 Disease Name  Pubmed Publications
 Liver Diseases Antibodies  >2 publications with SMC4/CAPC and Liver Diseases
 Carcinoma, Hepatocellular Antibodies  >2 publications with SMC4/CAPC and Carcinoma, Hepatocellular
 Breast Neoplasms Antibodies  >2 publications with SMC4/CAPC and Breast Neoplasms
 Liver Neoplasms Antibodies  >2 publications with SMC4/CAPC and Liver Neoplasms
 Nervous System Diseases Antibodies  >1 publications with SMC4/CAPC and Nervous System Diseases
 Lung Neoplasms Antibodies  >1 publications with SMC4/CAPC and Lung Neoplasms
 Cell Transformation, Neoplastic Antibodies  >1 publications with SMC4/CAPC and Cell Transformation, Neoplastic
 Neoplasm Metastasis Antibodies  >1 publications with SMC4/CAPC and Neoplasm Metastasis
 Poisoning Antibodies  >1 publications with SMC4/CAPC and Poisoning
 Neoplasms, Experimental Antibodies  >1 publications with SMC4/CAPC and Neoplasms, Experimental

Organs/Tissues associated with anti-SMC4/CAPC antibody

 Organ/Tissue Name  Pubmed Publications
 Muscle Antibodies  >2 publications with SMC4/CAPC and Muscle
 Lung Antibodies  >2 publications with SMC4/CAPC and Lung
 Liver Antibodies  >2 publications with SMC4/CAPC and Liver
 Brain Antibodies  >2 publications with SMC4/CAPC and Brain
 Eye Antibodies  >1 publications with SMC4/CAPC and Eye
 Intestine Antibodies  >1 publications with SMC4/CAPC and Intestine
 Blood Antibodies  >1 publications with SMC4/CAPC and Blood
 Ovary Antibodies  >1 publications with SMC4/CAPC and Ovary
 Heart Antibodies  >1 publications with SMC4/CAPC and Heart
 Testis Antibodies  >1 publications with SMC4/CAPC and Testis
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