Calcineurin A (PPP3CB) Antibody – Rabbit Polyclonal

PPP3CB: a calmodulin-dependent Ser/Thr phosphatase also known calcineurin A beta. Involved in a wide range of biologic activities, acting as a Ca(2 )-dependent modifier of phosphorylation status. The calcineurin holoenzyme is composed of catalytic and regulatory subunits of 60 and 18 kD, respectively.

Protein type: EC 3.1.3.16; Protein phosphatase, Ser/Thr (non-receptor)

Chromosomal Location of Human Ortholog: 10q22.2

Cellular Component: nucleoplasm; T-tubule; plasma membrane; cytosol; Z disc; calcineurin complex

Molecular Function: protein dimerization activity; calmodulin binding; protein binding; calmodulin-dependent protein phosphatase activity; enzyme binding; protein serine/threonine phosphatase activity; calcium ion binding; drug binding; protein phosphatase 2B binding

Biological Process: T cell activation; positive regulation of NFAT protein import into nucleus; axon extension; heart development; positive regulation of transcription, DNA-dependent; regulation of synaptic plasticity; social behavior; learning; signal transduction; protein amino acid dephosphorylation; protein amino acid phosphorylation; memory; calcium ion-dependent exocytosis; locomotion during locomotory behavior; T cell proliferation; calcineurin-NFAT signaling pathway; dephosphorylation; response to cytokine stimulus; negative regulation of T cell mediated cytotoxicity; innate immune response; T cell homeostasis; positive regulation of transcription from RNA polymerase II promoter; regulation of insulin secretion; T cell differentiation