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MARCKS Antibody – Rabbit Polyclonal

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS840440

Background: MARCKS (Myristoylated alanine-rich protein kinase C substrate) is a major PKC substrate that is distributed in various cell types. MARCKS has been implicated in cell motility, cell adhesion, phagocytosis, membrane traffic and mitogenesis. PKC… More details

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Product Overview

Product Name
MARCKS, Polyclonal Antibody
Full Product Name
Phospho-MARCKS Antibody
Product Gene Name
anti-MARCKS antibody
Product Synonym Names
MACS; PRKCSL; MRACKS; PKCSL; FLJ14368; FLJ90045; phosphomyristin
Clonality
Polyclonal
Isotype
IgG
Host
Rabbit
Species Reactivity
Human, Mouse, Rat
Form/Format
100 ul affinity purified rabbit anti-phospho-MARCKS polyclonal antibody in phosphate buffered saline (PBS), pH 7.2, containing 50% glycerol, 1% BSA, 0.02% thimerosal.
Appearance: Colorless liquid
Purity/Purification
Affinity purified
Concentration
0.5 mg/ml (lot specific)
Preparation and Storage
At -20 degree C
Shelf Life: 12 months
Molecular Weight
29,795 Da
3D Structure
ModBase 3D Structure for P30009
Immunogen
Synthetic peptide corresponding to amino acids surrounding Ser152/156 of rat MARCKS
Handling
The antibody solution should be gently mixed before use.
Applications Tested/Suitable for anti-MARCKS antibody
Western Blot (WB)
Application Notes for anti-MARCKS antibody
Western blotting (1:200-1000). However, the optimal conditions should be determined individually. Other applications have not been determined. The antibody detects 80 kDa MARCKS only when phosphorylated at Ser152/156.

Other Notes

Small volumes of anti-MARCKS antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for MARCKS purchase

MBS840440 is an antibody targeting MARCKS. Also known as Phospho-MARCKS Antibody. Reactive in Human, Mouse, Rat. Host: Rabbit.

Additional Details

NCBI/Uniprot data below describe general gene information for MARCKS. It may not necessarily be applicable to this product.

NCBI GI #
266495
NCBI GeneID
25603
NCBI Accession #
P30009.2
UniProt Primary Accession #
P30009
UniProt Secondary Accession #
P20468
UniProt Related Accession #
P30009
NCBI Official Full Name
Myristoylated alanine-rich C-kinase substrate
NCBI Official Synonym Full Names
myristoylated alanine rich protein kinase C substrate
NCBI Official Symbol
Marcks
NCBI Official Synonym Symbols
KINC; Macs
UniProt Protein Name
Myristoylated alanine-rich C-kinase substrate
UniProt Synonym Protein Names
Protein kinase C substrate 80 kDa protein
Protein Family
Myristoylated alanine-rich C-kinase substrate
UniProt Gene Name
Marcks
UniProt Synonym Gene Names
Macs; MARCKS
UniProt Entry Name
MARCS_RAT
NCBI Protein Information
myristoylated alanine-rich C-kinase substrate

NCBI Summary for MARCKS

protein kinase C (PKC) substrate and scaffolding protein [RGD, Feb 2006]

UniProt Comments for MARCKS

MARCKS: the most prominent cellular substrate of protein kinase C. Binds calmodulin, actin, and synapsin. A filamentous actin cross-linking protein. Critical for normal brain development. Phosphorylation by PKC displaces it from the plasma membrane, inhibiting F-actin cross-linking activity. Plays a role in growth cone adhesion: its nonphosphorylated form stabilizes integrin-mediated adhesions, and its phosphorylation-triggered release from adhesions causes localized growth cone detachment. Highly expressed in immature T and B lymphocytes: its expression is highest in CD4-8- T cells and B-cell blasts generated by antigen receptor signaling. Its expression and phosphorylation are closely linked to microglial activation processes involved in pathological conditions such as neuroinflammation and neurodegeneration.

Protein type: Motility/polarity/chemotaxis; Actin-binding

Cellular Component: germinal vesicle; microtubule; centrosome; focal adhesion; lysosome; dendritic spine; cell cortex; cytosol; growth cone; membrane; cytoplasm; plasma membrane; synapse; nerve terminal; outer dense fiber

Molecular Function: calmodulin binding; protein kinase C binding; phosphatidylserine binding; phospholipid binding; actin binding

Biological Process: intracellular protein transport; phospholipase D activation; actin filament organization; brain development; cell-substrate adhesion
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Research Articles on MARCKS

1. Either genetic silencing of MARCKS or disruption of its interaction with Rab10 inhibited axon growth of cortical neurons.

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Products associated with anti-MARCKS antibody

 Reference Product  PubMed Publications
 Prkca antibody  >11 publications with MARCKS and Prkca
 Prkcd antibody  >11 publications with MARCKS and Prkcd
 Prkce antibody  >8 publications with MARCKS and Prkce
 Mlp antibody  >6 publications with MARCKS and Mlp
 Prkcg antibody  >4 publications with MARCKS and Prkcg
 Cdk2 antibody  >2 publications with MARCKS and Cdk2
 Apoe antibody  >1 publications with MARCKS and Apoe

Pathways associated with anti-MARCKS antibody

 Products by Pathway  Pathway Diagram
 Acetylcholine Regulates Insulin Secretion Pathway antibodies  Acetylcholine Regulates Insulin Secretion Pathway Diagram
 Fc Gamma R-mediated Phagocytosis Pathway antibodies  Fc Gamma R-mediated Phagocytosis Pathway Diagram
 Fc Gamma R-mediated Phagocytosis Pathway antibodies  Fc Gamma R-mediated Phagocytosis Pathway Diagram
 Integration Of Energy Metabolism Pathway antibodies  Integration Of Energy Metabolism Pathway Diagram
 Metabolism Pathway antibodies  Metabolism Pathway Diagram
 MicroRNAs In Cancer Pathway antibodies  MicroRNAs In Cancer Pathway Diagram
 MicroRNAs In Cancer Pathway antibodies  MicroRNAs In Cancer Pathway Diagram
 Regulation Of Insulin Secretion Pathway antibodies  Regulation Of Insulin Secretion Pathway Diagram

Organs/Tissues associated with anti-MARCKS antibody

 Organ/Tissue Name  Pubmed Publications
 Brain Antibodies  >238 publications with MARCKS and Brain
 Nerve Antibodies  >85 publications with MARCKS and Nerve
 Muscle Antibodies  >50 publications with MARCKS and Muscle
 Lung Antibodies  >37 publications with MARCKS and Lung
 Embryonic Tissue Antibodies  >22 publications with MARCKS and Embryonic Tissue
 Eye Antibodies  >17 publications with MARCKS and Eye
 Heart Antibodies  >16 publications with MARCKS and Heart
 Pancreas Antibodies  >9 publications with MARCKS and Pancreas
 Ovary Antibodies  >8 publications with MARCKS and Ovary
 Dorsal Root Ganglion Antibodies  >4 publications with MARCKS and Dorsal Root Ganglion
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