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Bnip3L/NIX Antibody – Rabbit Polyclonal

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS840443

Background: Members of Bcl-2 family are critical regulators of apoptosis by either inhibiting or promoting cell death. Bcl-2 homology 3 (BH3) domain is a potent death domain. BH3 domain containing pro-apoptotic proteins, including Bad, Bax, Bid, Bik, Hrk,… More details

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Product Overview

Product Name
Bnip3L/Nix, Polyclonal Antibody
Full Product Name
Bnip3L / Nix Antibody
Product Gene Name
anti-Bnip3L/Nix antibody
Product Synonym Names
BCL2/adenovirus E1B 19 kDa protein-interacting protein 3-like; NIP3-like protein X
Clonality
Polyclonal
Isotype
IgG
Host
Rabbit
Species Reactivity
Human, Mouse
Form/Format
100 ug (0.5 mg/ml) affinity purified rabbit anti-Bnip3L polyclonal antibody in phosphate buffered saline (PBS), pH 7.2, containing 30% glycerol, 1% BSA, 0.02% thimerosal.
Appearance: Colorless liquid
Purity/Purification
Affinity purified
Concentration
0.5 mg/ml (lot specific)
Preparation and Storage
At -20 degree C
Shelf Life: 12 months
Molecular Weight
19,559 Da
OMIM
605368
3D Structure
ModBase 3D Structure for O60238
Immunogen
Synthetic peptide surrounding amino acid 80 of human Bnip3L.
Handling
The antibody solution should be gently mixed before use.

Product Categories/Family for anti-Bnip3L/Nix antibody

Apoptosis & Related Products; Autophagy; Autophagy AntibodiesSignaling Pathways; PI3 K/Akt/mTOR Signaling; AntibodiesAntibodies & Supporting Tools; Primary Antibodies (A-Z)
Applications Tested/Suitable for anti-Bnip3L/Nix antibody
Western Blot (WB), Immunohistochemistry (IHC)
Application Notes for anti-Bnip3L/Nix antibody
The antibody can be used for Western blot analysis (0.5-2 ug/ml) and immunohistochemistry (2-10 ug/ml). The optimal conditions should be determined individually. Other applications have not been tested.

Other Notes

Small volumes of anti-Bnip3L/Nix antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for Bnip3L/Nix purchase

MBS840443 is an antibody targeting Bnip3L/Nix. Also known as Bnip3L / Nix Antibody. Reactive in Human, Mouse. Host: Rabbit.

Additional Details

NCBI/Uniprot data below describe general gene information for Bnip3L/Nix. It may not necessarily be applicable to this product.

NCBI GI #
4757860
NCBI GeneID
665
NCBI Accession #
NP_004322.1
UniProt Primary Accession #
O60238
UniProt Secondary Accession #
Q5JW63; Q8NF87; B0AZS9
UniProt Related Accession #
O60238
GenBank Nucleotide #
NM_004331.2
NCBI Official Full Name
BCL2/adenovirus E1B 19 kDa protein-interacting protein 3-like
NCBI Official Synonym Full Names
BCL2/adenovirus E1B 19kDa interacting protein 3-like
NCBI Official Symbol
BNIP3L
NCBI Official Synonym Symbols
NIX; BNIP3a
UniProt Protein Name
BCL2/adenovirus E1B 19 kDa protein-interacting protein 3-like
UniProt Synonym Protein Names
Adenovirus E1B19K-binding protein B5; BCL2/adenovirus E1B 19 kDa protein-interacting protein 3A; NIP3-like protein X; NIP3L
UniProt Gene Name
BNIP3L
UniProt Synonym Gene Names
BNIP3A; BNIP3H; NIX; NIP3L
UniProt Entry Name
BNI3L_HUMAN
NCBI Protein Information
BCL2/adenovirus E1B 19 kDa protein-interacting protein 3-like

NCBI Summary for Bnip3L/Nix

This gene encodes a protein that belongs to the pro-apoptotic subfamily within the Bcl-2 family of proteins. The encoded protein binds to Bcl-2 and possesses the BH3 domain. The protein directly targets mitochondria and causes apoptotic changes, including loss of membrane potential and the release of cytochrome c. [provided by RefSeq, Feb 2015]
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UniProt Comments for Bnip3L/Nix

BNIP3L: Induces apoptosis. Interacts with viral and cellular anti-apoptosis proteins. Can overcome the suppressors BCL-2 and BCL-XL, although high levels of BCL-XL expression will inhibit apoptosis. Inhibits apoptosis induced by BNIP3. Involved in mitochondrial quality control via its interaction with SPATA18/MIEAP: in response to mitochondrial damage, participates to mitochondrial protein catabolic process (also named MALM) leading to the degradation of damaged proteins inside mitochondria. May function as a tumor suppressor. Self-associates. Interacts with BNIP3 and STEAP3. Interacts with SPATA18/MIEAP. Interacts with human adenovirus-2 E1B 19 kDa protein. Belongs to the NIP3 family.

Protein type: Apoptosis; Membrane protein, integral; Mitochondrial; Endoplasmic reticulum; Nuclear envelope

Chromosomal Location of Human Ortholog: 8p21

Cellular Component: mitochondrial outer membrane; mitochondrion; endoplasmic reticulum; integral to membrane; nuclear envelope; intrinsic to membrane

Molecular Function: identical protein binding; protein binding; protein homodimerization activity; protein heterodimerization activity; lamin binding

Biological Process: viral reproduction; positive regulation of apoptosis; defense response to virus; negative regulation of apoptosis
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Research Articles on Bnip3L/Nix

1. Nix protein positively regulates NF-kappaB activation in gliomas

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Products associated with anti-Bnip3L/Nix antibody

 Reference Product  PubMed Publications
 BNIP3 antibody  >96 publications with Bnip3L/Nix and BNIP3
 BCL2 antibody  >23 publications with Bnip3L/Nix and BCL2
 GABARAP antibody  >4 publications with Bnip3L/Nix and GABARAP
 TP53 antibody  >4 publications with Bnip3L/Nix and TP53
 CREBBP antibody  >1 publications with Bnip3L/Nix and CREBBP

Diseases associated with anti-Bnip3L/Nix antibody

 Disease Name  Pubmed Publications
 Cardiovascular Diseases Antibodies  >16 publications with Bnip3L/Nix and Cardiovascular Diseases
 Heart Diseases Antibodies  >15 publications with Bnip3L/Nix and Heart Diseases
 Necrosis Antibodies  >14 publications with Bnip3L/Nix and Necrosis
 Breast Neoplasms Antibodies  >13 publications with Bnip3L/Nix and Breast Neoplasms
 Nervous System Diseases Antibodies  >9 publications with Bnip3L/Nix and Nervous System Diseases
 Brain Diseases Antibodies  >8 publications with Bnip3L/Nix and Brain Diseases
 Cardiomyopathies Antibodies  >6 publications with Bnip3L/Nix and Cardiomyopathies
 Disease Models, Animal Antibodies  >6 publications with Bnip3L/Nix and Disease Models, Animal
 Liver Neoplasms Antibodies  >5 publications with Bnip3L/Nix and Liver Neoplasms
 Neoplasm Metastasis Antibodies  >5 publications with Bnip3L/Nix and Neoplasm Metastasis

Organs/Tissues associated with anti-Bnip3L/Nix antibody

 Organ/Tissue Name  Pubmed Publications
 Heart Antibodies  >23 publications with Bnip3L/Nix and Heart
 Blood Antibodies  >19 publications with Bnip3L/Nix and Blood
 Muscle Antibodies  >18 publications with Bnip3L/Nix and Muscle
 Liver Antibodies  >11 publications with Bnip3L/Nix and Liver
 Brain Antibodies  >11 publications with Bnip3L/Nix and Brain
 Vascular Antibodies  >10 publications with Bnip3L/Nix and Vascular
 Lung Antibodies  >9 publications with Bnip3L/Nix and Lung
 Embryonic Tissue Antibodies  >6 publications with Bnip3L/Nix and Embryonic Tissue
 Kidney Antibodies  >5 publications with Bnip3L/Nix and Kidney
 Prostate Antibodies  >5 publications with Bnip3L/Nix and Prostate
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