Rabbit Anti-CXCR5 Polyclonal Antibody – Cat# MBS840458

CXCR5 Antibody – Rabbit Polyclonal

Name: CXCR5 Antibody; Polyclonal; Rabbit; Human-Reactive; MyBioSource
Brand: MyBioSource
SKU: MBS840458
Price: 215 USD
Availability: InStock
Rating: 5 (10 reviews)

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS840458

Background: Chemokines play an important role in inflammation and critical for the recruitment of effector immune cells to sites of infection. Chemokines activate leukocytes by binding to G protein coupled receptors. The ever-growing chemokine receptor… More details

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Product Documentation

Sample Manual Insert View PDF

Testing Data View PDF

Certificate of Analysis (COA) View PDF

QC Report View PDF

Material Safety Data Sheet View PDF

Technical Datasheet View PDF

Protocol View PDF

Product Overview

Product Name

CXCR5, Polyclonal Antibody

Full Product Name

CXCR5 Antibody

Product Gene Name

anti-CXCR5 antibody

Product Synonym Names

CXCR5; MDR15; CD185; C-X-C chemokine receptor type 5; BLR1

Clonality

Polyclonal

Isotype

IgG

Host

Rabbit

Species Reactivity

Human

Form/Format

100 ug (0.5 mg/ml) affinity purified rabbit polyclonal antibody in phosphate-buffered saline (PBS) containing 30% glycerol, 0.5% BSA, and 0.01% thimerosal.
Appearance: Colorless liquid

Purity/Purification

Affinity purified

Concentration

0.5 mg/ml (lot specific)

Preparation and Storage

At -20 degree C
Shelf Life: 12 months

Molecular Weight

36,676 Da

OMIM

601613

3D Structure

ModBase 3D Structure for P32302

Immunogen

Synthetic peptide surrounding amino acid 359 of human CXCR5

Handling

The antibody solution should be gently mixed before use.

Applications Tested/Suitable for anti-CXCR5 antibody

Western Blot (WB), Immunohistochemistry (IHC)

Application Notes for anti-CXCR5 antibody

Western blotting (0.5-4 ug/ml). However, the optimal concentrations should be determined individually. The antibody recognizes 36 kDa CXCR5 of human origin. Reactivity to other species has not been tested.

Other Notes

Small volumes of anti-CXCR5 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for CXCR5 purchase

MBS840458 is an antibody targeting CXCR5. Also known as CXCR5 Antibody. Reactive in Human. Host: Rabbit.

Additional Details

NCBI/Uniprot data below describe general gene information for CXCR5. It may not necessarily be applicable to this product.

NCBI GI #

4502415

NCBI GeneID

643

NCBI Accession #

NP_001707.1

UniProt Primary Accession #

P32302

UniProt Secondary Accession #

Q14811

UniProt Related Accession #

P32302

GenBank Nucleotide #

NM_001716.4

NCBI Official Full Name

C-X-C chemokine receptor type 5 isoform 1

NCBI Official Synonym Full Names

chemokine (C-X-C motif) receptor 5

NCBI Official Symbol

CXCR5

NCBI Official Synonym Symbols

BLR1; CD185; MDR15

UniProt Protein Name

C-X-C chemokine receptor type 5

UniProt Synonym Protein Names

Burkitt lymphoma receptor 1; Monocyte-derived receptor 15; MDR-15; CD_antigen: CD185

Protein Family

C-X-C chemokine receptor

UniProt Gene Name

CXCR5

UniProt Synonym Gene Names

BLR1; MDR15; CXC-R5; CXCR-5; MDR-15

UniProt Entry Name

CXCR5_HUMAN

NCBI Protein Information

C-X-C chemokine receptor type 5

NCBI Summary for CXCR5

This gene encodes a multi-pass membrane protein that belongs to the CXC chemokine receptor family. It is expressed in mature B-cells and Burkitt's lymphoma. This cytokine receptor binds to B-lymphocyte chemoattractant (BLC), and is involved in B-cell migration into B-cell follicles of spleen and Peyer patches. Alternatively spliced transcript variants encoding different isoforms have been described for this gene. [provided by RefSeq, Aug 2011]

UniProt Comments for CXCR5

CXCR5: Cytokine receptor that binds to B-lymphocyte chemoattractant (BLC). Involved in B-cell migration into B-cell follicles of spleen and Peyer patches but not into those of mesenteric or peripheral lymph nodes. May have a regulatory function in Burkitt lymphoma (BL) lymphomagenesis and/or B-cell differentiation. Belongs to the G-protein coupled receptor 1 family. 2 isoforms of the human protein are produced by alternative splicing.

Protein type: Receptor, GPCR; Membrane protein, integral; Membrane protein, multi-pass; GPCR, family 1

Chromosomal Location of Human Ortholog: 11q23.3

Cellular Component: integral to plasma membrane; plasma membrane; external side of plasma membrane

Molecular Function: G-protein coupled receptor activity; protein binding; C-X-C chemokine receptor activity

Biological Process: positive regulation of cytokinesis; G-protein coupled receptor protein signaling pathway; B cell activation; immune response; cell motility; chemotaxis; lymph node development

Research Articles on CXCR5

1. After validation in larger patient groups, CXCR5 and CXCL13 may prove useful as biomarkers for nonsmall cell lung carcinoma Correspondingly, blockade of this axis could serve as an effective therapy for nonsmall cell lung carcinoma.

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Products associated with anti-CXCR5 antibody

Reference Product	PubMed Publications
CXCL13 antibody	>199 publications with CXCR5 and CXCL13
CXCR4 antibody	>142 publications with CXCR5 and CXCR4
CXCL12 antibody	>67 publications with CXCR5 and CXCL12
CCL19 antibody	>32 publications with CXCR5 and CCL19
CCL21 antibody	>30 publications with CXCR5 and CCL21
CCL5 antibody	>15 publications with CXCR5 and CCL5
CCL4 antibody	>5 publications with CXCR5 and CCL4
CCL28 antibody	>2 publications with CXCR5 and CCL28
CCL27 antibody	>1 publications with CXCR5 and CCL27

Pathways associated with anti-CXCR5 antibody

Products by Pathway	Pathway Diagram
Chemokine Receptors Bind Chemokines Pathway antibodies	Chemokine Receptors Bind Chemokines Pathway Diagram
Chemokine Signaling Pathway antibodies	Chemokine Signaling Pathway Diagram
Chemokine Signaling Pathway antibodies	Chemokine Signaling Pathway Diagram
Class A/1 (Rhodopsin-like Receptors) Pathway antibodies	Class A/1 (Rhodopsin-like Receptors) Pathway Diagram
Cytokine-cytokine Receptor Interaction Pathway antibodies	Cytokine-cytokine Receptor Interaction Pathway Diagram
Cytokine-cytokine Receptor Interaction Pathway antibodies	Cytokine-cytokine Receptor Interaction Pathway Diagram
G Alpha (i) Signalling Events Pathway antibodies	G Alpha (i) Signalling Events Pathway Diagram
GPCR Downstream Signaling Pathway antibodies	GPCR Downstream Signaling Pathway Diagram
GPCR Ligand Binding Pathway antibodies	GPCR Ligand Binding Pathway Diagram
GPCRs, Class A Rhodopsin-like Pathway antibodies	GPCRs, Class A Rhodopsin-like Pathway Diagram

Diseases associated with anti-CXCR5 antibody

Disease Name	Pubmed Publications
Inflammation Antibodies	>92 publications with CXCR5 and Inflammation
Necrosis Antibodies	>42 publications with CXCR5 and Necrosis
Disease Models, Animal Antibodies	>37 publications with CXCR5 and Disease Models, Animal
Kidney Diseases Antibodies	>21 publications with CXCR5 and Kidney Diseases
Carcinoma Antibodies	>20 publications with CXCR5 and Carcinoma
Lung Diseases Antibodies	>19 publications with CXCR5 and Lung Diseases
Liver Diseases Antibodies	>19 publications with CXCR5 and Liver Diseases
Neoplasms, Experimental Antibodies	>17 publications with CXCR5 and Neoplasms, Experimental
Skin Diseases Antibodies	>17 publications with CXCR5 and Skin Diseases
Prostatic Neoplasms Antibodies	>8 publications with CXCR5 and Prostatic Neoplasms

Organs/Tissues associated with anti-CXCR5 antibody

Organ/Tissue Name	Pubmed Publications
Blood Antibodies	>543 publications with CXCR5 and Blood
Lymph Node Antibodies	>213 publications with CXCR5 and Lymph Node
Lymph Antibodies	>120 publications with CXCR5 and Lymph
Spleen Antibodies	>79 publications with CXCR5 and Spleen
Pharynx Antibodies	>31 publications with CXCR5 and Pharynx
Thymus Antibodies	>25 publications with CXCR5 and Thymus
Lung Antibodies	>22 publications with CXCR5 and Lung
Skin Antibodies	>19 publications with CXCR5 and Skin
Intestine Antibodies	>17 publications with CXCR5 and Intestine
Prostate Antibodies	>11 publications with CXCR5 and Prostate