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SLK Antibody – Rabbit Polyclonal

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS840468

Background: SLK (STE20-like kinase), also known as STK2 (serine/threonine protein kinase 2) or se20-9, is a member of the serine/threonine kinase subfamily, Ste20. This subfamily is comprised of several mammalian kinases which exhibit sequence similarity to… More details

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Product Overview

Product Name
SLK, Polyclonal Antibody
Full Product Name
SLK Antibody
Product Gene Name
anti-SLK antibody
Product Synonym Names
SLK; STE20-like Kinase; SLK; Sucrose nonfermenting like kinase; STK2; Serine/Threonine Kinase 2
Clonality
Polyclonal
Isotype
IgG
Host
Rabbit
Species Reactivity
Human, Mouse
Form/Format
100 ul affinity purified rabbit polyclonal antibody in phosphate-buffered saline (PBS) containing 30% glycerol, 1% BSA and 0.02% thimerosal.
Appearance: Colorless liquid
Purity/Purification
Affinity purified
Preparation and Storage
At -20 degree C
Shelf Life: 12 months
Molecular Weight
138,996 Da
Immunogen
Synthetic peptide of human SLK
Handling
The antibody solution should be gently mixed before use.
Applications Tested/Suitable for anti-SLK antibody
Western Blot (WB), Immunoprecipitation (IP)
Application Notes for anti-SLK antibody
Western blotting (1:500 - 1:2500) and immunoprecipitation. However, the optimal concentrations should be determined individually. The antibody recognizes the SLK of human and mouse origin. Reactivity to other species has not been tested.

Other Notes

Small volumes of anti-SLK antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for SLK purchase

MBS840468 is an antibody targeting SLK. Also known as SLK Antibody. Reactive in Human, Mouse. Host: Rabbit.

Additional Details

NCBI/Uniprot data below describe general gene information for SLK. It may not necessarily be applicable to this product.

NCBI GI #
41281453
NCBI GeneID
9748
NCBI Accession #
NP_055535.2
UniProt Secondary Accession #
O00211; Q6P1Z4; Q86WU7; Q86WW1; Q92603; Q9NQL0; Q9NQL1; D3DRA0; D3DRA1
UniProt Related Accession #
Q9H2G2
GenBank Nucleotide #
NM_014720.3
NCBI Official Full Name
STE20-like serine/threonine-protein kinase isoform 1
NCBI Official Synonym Full Names
STE20-like kinase
NCBI Official Symbol
SLK
NCBI Official Synonym Symbols
LOSK; STK2; se20-9; bA16H23.1
UniProt Protein Name
STE20-like serine/threonine-protein kinase
UniProt Synonym Protein Names
CTCL tumor antigen se20-9; STE20-related serine/threonine-protein kinase; STE20-related kinase; Serine/threonine-protein kinase 2
Protein Family
STE20-like serine/threonine-protein kinase
UniProt Gene Name
SLK
UniProt Synonym Gene Names
KIAA0204; STK2; STE20-like kinase; hSLK; STE20-related kinase
UniProt Entry Name
SLK_HUMAN
NCBI Protein Information
STE20-like serine/threonine-protein kinase

UniProt Comments for SLK

SLK: a microtubule-associated protein kinase required for progression through G2. Co-localizes with the mitotic spindle in cells undergoing mitosis. Regulates actin reorganization during cell adhesion and spreading via a Rac1-mediated pathway. Signals via ASK1 and p38 to promote apoptosis. Activated in response to anoxia and ischemia-reperfusion injury in cell culture. It inhibits the protective aspects of the endoplasmic reticulum stress response, thus contributing to its proapoptotic effect. Two alternatively-spliced isoforms have been described.

Protein type: Protein kinase, STE; Kinase, protein; EC 2.7.11.1; Protein kinase, Ser/Thr (non-receptor); STE group; STE20 family; SLK subfamily

Chromosomal Location of Human Ortholog: 10q24.33

Cellular Component: cytoplasm

Molecular Function: protein serine/threonine kinase activity; identical protein binding; protein homodimerization activity; ATP binding; receptor signaling protein serine/threonine kinase activity

Biological Process: apoptosis; protein amino acid autophosphorylation
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Research Articles on SLK

1. SLK activated ERMs, together with Galphai, are critical for the correct localization of LGN-NuMA force generator complexes and hence for proper spindle orientation.

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Products associated with anti-SLK antibody

 Reference Product  PubMed Publications
 PLK1 antibody  >5 publications with SLK and PLK1
 FYN antibody  >3 publications with SLK and FYN
 LDB2 antibody  >2 publications with SLK and LDB2
 CASP3 antibody  >2 publications with SLK and CASP3
 PXN antibody  >1 publications with SLK and PXN
 RHOA antibody  >1 publications with SLK and RHOA

Diseases associated with anti-SLK antibody

 Disease Name  Pubmed Publications
 Kidney Diseases Antibodies  >38 publications with SLK and Kidney Diseases
 Cardiovascular Diseases Antibodies  >32 publications with SLK and Cardiovascular Diseases
 Vascular Diseases Antibodies  >28 publications with SLK and Vascular Diseases
 Liver Diseases Antibodies  >27 publications with SLK and Liver Diseases
 Inflammation Antibodies  >17 publications with SLK and Inflammation
 Adenocarcinoma Antibodies  >12 publications with SLK and Adenocarcinoma
 Carcinoma, Hepatocellular Antibodies  >10 publications with SLK and Carcinoma, Hepatocellular
 Fibrosis Antibodies  >10 publications with SLK and Fibrosis
 Necrosis Antibodies  >9 publications with SLK and Necrosis
 Disease Models, Animal Antibodies  >8 publications with SLK and Disease Models, Animal

Organs/Tissues associated with anti-SLK antibody

 Organ/Tissue Name  Pubmed Publications
 Kidney Antibodies  >72 publications with SLK and Kidney
 Blood Antibodies  >53 publications with SLK and Blood
 Liver Antibodies  >47 publications with SLK and Liver
 Eye Antibodies  >34 publications with SLK and Eye
 Prostate Antibodies  >28 publications with SLK and Prostate
 Vascular Antibodies  >23 publications with SLK and Vascular
 Bladder Antibodies  >19 publications with SLK and Bladder
 Nerve Antibodies  >18 publications with SLK and Nerve
 Brain Antibodies  >14 publications with SLK and Brain
 Lymph Antibodies  >12 publications with SLK and Lymph
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