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MyD88 Antibody – Rabbit Polyclonal

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS840479

Background: MyD88 was identified as an adapter molecule in the IL-1 signaling pathway. MyD88 associates with and recruits IRAK to the IL-1 receptor complex in response to IL-1 treatment. Dominant-negative form of MyD88 attenuates IL-1R-mediated NF-?B… More details

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Sample Manual Insert View PDF
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Testing Data View PDF
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Technical Datasheet View PDF
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Product Overview

Product Name
MyD88, Polyclonal Antibody
Full Product Name
MyD88 Antibody
Product Gene Name
Product Synonym Names
Myeloid differentiation primary response protein; MyD88
Clonality
Polyclonal
Isotype
IgG
Host
Rabbit
Species Reactivity
Human, Mouse, Rat, Monkey
Form/Format
100 ug (0.5 mg/ml) affinity purified rabbit anti- MyD88 polyclonal antibody in phosphate buffered saline (PBS), pH 7.2, containing 30% glycerol, 0.5% BSA, 5 mM EDTA and 0.01% thimerosal
Appearance: Colorless liquid
Purity/Purification
Affinity purified
Concentration
0.5 mg/ml (lot specific)
Preparation and Storage
At -20 degree C
Shelf Life: 12 months
Molecular Weight
33,856 Da
3D Structure
ModBase 3D Structure for Q6Y1S1
Immunogen
Synthetic peptide surrounding amino acid 283 of rat MyD88
Positive Control
Rat kidney tissue lysate
Handling
The antibody solution should be gently mixed before use.
Applications Tested/Suitable for anti-MyD88 antibody
Western Blot (WB)
Application Notes for anti-MyD88 antibody
Western Blot analysis (0.5-4 ug/ml). However, the optimal concentrations should be determined individually. Blocking peptide is available separately.

Testing Data of anti-MyD88 antibody

Rabbit Anti-MyD88 Polyclonal Antibody – Cat# MBS840479

Other Notes

Small volumes of anti-MyD88 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for MyD88 purchase

MBS840479 is an antibody targeting MyD88. Also known as MyD88 Antibody. Reactive in Human, Mouse, Rat, Monkey. Host: Rabbit.

Additional Details

NCBI/Uniprot data below describe general gene information for MyD88. It may not necessarily be applicable to this product.

NCBI GI #
NCBI GeneID
NCBI Accession #
UniProt Primary Accession #
UniProt Secondary Accession #
UniProt Related Accession #
GenBank Nucleotide #
NCBI Official Full Name
myeloid differentiation primary response protein MyD88
NCBI Official Synonym Full Names
myeloid differentiation primary response 88
NCBI Official Symbol
Myd88
UniProt Protein Name
Myeloid differentiation primary response protein MyD88
UniProt Gene Name
Myd88
UniProt Entry Name
MYD88_RAT
NCBI Protein Information
myeloid differentiation primary response protein MyD88

NCBI Summary for MyD88

an adaptor protein which binds toll-like receptors and links them to other downstream signalling molecules [RGD, Feb 2006]

UniProt Comments for MyD88

Adapter protein involved in the Toll-like receptor and IL-1 receptor signaling pathway in the innate immune response. Acts via IRAK1, IRAK2, IRF7 and TRAF6, leading to NF-kappa-B activation, cytokine secretion and the inflammatory response. Increases IL-8 transcription. Involved in IL-18-mediated signaling pathway. Activates IRF1 resulting in its rapid migration into the nucleus to mediate an efficient induction of IFN-beta, NOS2/INOS, and IL12A genes (). MyD88-mediated signaling in intestinal epithelial cells is crucial for maintenance of gut homeostasis and controls the expression of the antimicrobial lectin REG3G in the small intestine ().
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Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

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