Beta Receptor II (TGF) Antibody – Rabbit Polyclonal

TGFBR2: a TKL kinase of the serine/threonine-protein kinase receptor (STKR) family. R1 and R2 TGF-beta receptors dimerize after binding TGF-beta at the cell surface. Binds to DAXX. Defects can cause esophageal cancer.

Protein type: Kinase, protein; Protein kinase, Ser/Thr (receptor); Membrane protein, integral; Protein kinase, TKL; Oncoprotein; EC 2.7.11.30; TKL group; STKR family; Type2 subfamily

Cellular Component: cell surface; integral to plasma membrane; cytoplasm; integral to membrane; caveola; cytosol; receptor complex; external side of plasma membrane; lipid raft

Molecular Function: protein homodimerization activity; glycosaminoglycan binding; metal ion binding; mitogen-activated protein kinase kinase kinase binding; transmembrane receptor protein serine/threonine kinase activity; transforming growth factor beta receptor activity; protein binding; transforming growth factor beta receptor activity, type II; transforming growth factor beta binding; protein heterodimerization activity; SMAD binding; ATP binding; receptor signaling protein serine/threonine kinase activity

Biological Process: lens development in camera-type eye; wound healing; apoptosis; positive regulation of smooth muscle cell proliferation; heart development; myeloid dendritic cell differentiation; gastrulation; palate development; positive regulation of tolerance induction to self antigen; protein amino acid phosphorylation; response to organic cyclic substance; response to organic substance; negative regulation of cell proliferation; negative regulation of cardiac muscle cell proliferation; transforming growth factor beta receptor signaling pathway; positive regulation of mesenchymal cell proliferation; transmembrane receptor protein serine/threonine kinase signaling pathway; response to glucose stimulus; positive regulation of NK T cell differentiation; vasculogenesis; response to nutrient; positive regulation of T cell tolerance induction; aging; response to drug; receptor-mediated endocytosis; smoothened signaling pathway; organ regeneration; positive regulation of skeletal muscle regeneration; in utero embryonic development; embryonic hemopoiesis; common-partner SMAD protein phosphorylation; peptidyl-threonine phosphorylation; embryonic cranial skeleton morphogenesis; regulation of cell proliferation; patterning of blood vessels; organ morphogenesis; peptidyl-serine phosphorylation; positive regulation of angiogenesis; gut development; response to estrogen stimulus; response to steroid hormone stimulus; regulation of gene expression; response to mechanical stimulus; cartilage development; positive regulation of B cell tolerance induction; activation of protein kinase activity; response to hypoxia; brain development; embryo implantation; lung development