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DNA Binding Protein-7 (DBP-7) (CHD7) Antibody – Rabbit Polyclonal

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS840528

Background: DNA binding protein 7 (DBP-7) is also known as Chd7. Mutations in the Chd7 gene is believed to be a major implication of CHARGE syndrome. CHARGE syndrome is associated with anomalies such as malformations of the heart, inner ear, retina and… More details

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Product Overview

Product Name
DNA Binding Protein-7 (DBP-7) (CHD7), Polyclonal Antibody
Full Product Name
DNA Binding Protein-7 (DBP-7) Antibody
Product Gene Name
anti-CHD7 antibody
Product Synonym Names
DNA Binding Protein 7; DNA Binding Protein-7
Clonality
Polyclonal
Isotype
IgG
Host
Rabbit
Species Reactivity
Human
Form/Format
100 ug (0.5 mg/ml) affinity purified rabbit anti-human DBP-7 polyclonal antibody in phosphate buffered saline (PBS), pH 7.2, containing 30% glycerol, 0.5% BSA, 0.01% thimerosal
Appearance: Colorless liquid
Purity/Purification
Affinity purified
Concentration
0.5 mg/ml (lot specific)
Preparation and Storage
At -20 degree C
Shelf Life: 12 months
Molecular Weight
101,085 Da
OMIM
214800
Immunogen
E. coli expressed recombinant human DBP-7
Handling
The antibody solution should be gently mixed before use.
Applications Tested/Suitable for anti-CHD7 antibody
Western Blot (WB)
Application Notes for anti-CHD7 antibody
Western blot analysis (0.5-4 ug/ml). However, the optimal conditions should be determined individually. Recombinant DBP-7 can be used as a positive control.

Testing Data of anti-CHD7 antibody

Rabbit Anti-CHD7 Polyclonal Antibody – Cat# MBS840528

Other Notes

Small volumes of anti-CHD7 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for CHD7 purchase

MBS840528 is an antibody targeting CHD7. Also known as DNA Binding Protein-7 (DBP-7) Antibody. Reactive in Human. Host: Rabbit.

Additional Details

NCBI/Uniprot data below describe general gene information for CHD7. It may not necessarily be applicable to this product.

NCBI GI #
54112403
NCBI GeneID
55636
NCBI Accession #
NP_060250
UniProt Secondary Accession #
Q05DI5; Q2TAN4; Q66K35; Q7Z6C0; Q7Z7Q2; Q9NXA0; Q9NXA3; D0VBA5; E9PNZ2
UniProt Related Accession #
Q9P2D1
GenBank Nucleotide #
NM_017780.3
NCBI Official Full Name
chromodomain-helicase-DNA-binding protein 7
NCBI Official Synonym Full Names
chromodomain helicase DNA binding protein 7
NCBI Official Symbol
CHD7
NCBI Official Synonym Symbols
CRG; HH5; IS3; KAL5
UniProt Protein Name
Chromodomain-helicase-DNA-binding protein 7
UniProt Synonym Protein Names
ATP-dependent helicase CHD7
Protein Family
Chromodomain-helicase-DNA-binding protein
UniProt Gene Name
CHD7
UniProt Synonym Gene Names
KIAA1416; CHD-7
UniProt Entry Name
CHD7_HUMAN
NCBI Protein Information
chromodomain-helicase-DNA-binding protein 7

NCBI Summary for CHD7

This gene encodes a protein that contains several helicase family domains. Mutations in this gene have been found in some patients with the CHARGE syndrome. [provided by RefSeq, Jul 2008]

UniProt Comments for CHD7

CHD-7: Probable transcription regulator. May interact with CTCF. Interacts with CHD8. Widely expressed in fetal and adult tissues. Belongs to the SNF2/RAD54 helicase family. 2 isoforms of the human protein are produced by alternative splicing.

Protein type: Nucleolus; Helicase; DNA-binding; EC 3.6.4.12

Chromosomal Location of Human Ortholog: 8q12.2

Cellular Component: nucleoplasm; nucleolus; nucleus

Molecular Function: protein binding; DNA binding; chromatin binding; helicase activity; ATP binding

Biological Process: limb development; heart morphogenesis; central nervous system development; olfactory behavior; blood circulation; palate development; positive regulation of multicellular organism growth; regulation of growth hormone secretion; adult walking behavior; female genitalia development; olfactory nerve development; embryonic hindlimb morphogenesis; regulation of neurogenesis; sensory perception of sound; regulation of transcription, DNA-dependent; skeletal development; T cell differentiation; adult heart development; inner ear morphogenesis; transcription, DNA-dependent; in utero embryonic development; olfactory bulb development; semicircular canal morphogenesis; cranial nerve development; chromatin modification; genitalia development; retina development in camera-type eye; artery morphogenesis; cognition; nose development; rRNA processing

Disease: Charge Syndrome; Tracheoesophageal Fistula With Or Without Esophageal Atresia; Hypogonadotropic Hypogonadism 5 With Or Without Anosmia
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Research Articles on CHD7

1. CHD7 mutations are not a major cause of atrioventricular septal and conotruncal heart defects.

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Products associated with anti-CHD7 antibody

 Reference Product  PubMed Publications
 FGF8 antibody  >28 publications with CHD7 and FGF8
 PROKR2 antibody  >26 publications with CHD7 and PROKR2
 SMARCA4 antibody  >1 publications with CHD7 and SMARCA4
 SETDB1 antibody  >1 publications with CHD7 and SETDB1
 NLK antibody  >1 publications with CHD7 and NLK

Pathways associated with anti-CHD7 antibody

 Products by Pathway  Pathway Diagram
 Noncanonical Wnt Signaling Pathway antibodies  Noncanonical Wnt Signaling Pathway Diagram

Diseases associated with anti-CHD7 antibody

 Disease Name  Pubmed Publications
 CHARGE Syndrome Antibodies  >185 publications with CHD7 and CHARGE Syndrome
 Kallmann Syndrome Antibodies  >38 publications with CHD7 and Kallmann Syndrome
 Idiopathic Hypogonadotropic Hypogonadism Antibodies  >9 publications with CHD7 and Idiopathic Hypogonadotropic Hypogonadism
 Death Antibodies  >6 publications with CHD7 and Death
 Fetal Growth Retardation Antibodies  >3 publications with CHD7 and Fetal Growth Retardation
 Brain Diseases Antibodies  >2 publications with CHD7 and Brain Diseases
 Ovarian Diseases Antibodies  >2 publications with CHD7 and Ovarian Diseases
 Infertility, Male Antibodies  >2 publications with CHD7 and Infertility, Male
 Birth Weight Antibodies  >1 publications with CHD7 and Birth Weight
 Prenatal Exposure Delayed Effects Antibodies  >1 publications with CHD7 and Prenatal Exposure Delayed Effects

Organs/Tissues associated with anti-CHD7 antibody

 Organ/Tissue Name  Pubmed Publications
 Heart Antibodies  >97 publications with CHD7 and Heart
 Nerve Antibodies  >31 publications with CHD7 and Nerve
 Brain Antibodies  >29 publications with CHD7 and Brain
 Eye Antibodies  >26 publications with CHD7 and Eye
 Bone Antibodies  >23 publications with CHD7 and Bone
 Embryonic Tissue Antibodies  >14 publications with CHD7 and Embryonic Tissue
 Blood Antibodies  >14 publications with CHD7 and Blood
 Mouth Antibodies  >5 publications with CHD7 and Mouth
 Thymus Antibodies  >4 publications with CHD7 and Thymus
 Muscle Antibodies  >3 publications with CHD7 and Muscle
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