RICTOR Antibody – Rabbit Polyclonal

RICTOR: a regulatory binding partner of the kinase mTOR. Part of a rapamycin-insensitive and raptor-independent pathway that regulates the cytoskeleton. Rictor interacts with Cullin1-Rbx1 to form an E3 ubiquitin ligase complex, and promotes ubiquitination and degradation of SGK1. Shares homology with pianissimo from D. discoidieum, STE20p from S. pombe, and AVO3p from S. cerevisiae.

Protein type: Cell cycle regulation; Adaptor/scaffold; Ubiquitin conjugating system

Cellular Component: TORC2 complex

Molecular Function: protein binding; ribosome binding; protein kinase binding

Biological Process: regulation of GTPase activity; TOR signaling pathway; regulation of phosphorylation; multicellular organismal development; regulation of peptidyl-serine phosphorylation; regulation of protein kinase B signaling cascade; positive regulation of protein kinase B signaling cascade; peptidyl-serine phosphorylation; embryonic development; positive regulation of peptidyl-tyrosine phosphorylation; positive regulation of actin filament polymerization; regulation of gene expression; regulation of actin cytoskeleton organization and biogenesis; actin cytoskeleton reorganization; regulation of inflammatory response; positive regulation of endothelial cell proliferation; positive regulation of TOR signaling pathway