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MIP-2 Antibody – Rabbit Polyclonal

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS840551

Background: MIP-2 (macrophage inflammatory protein-2) is a 69-amino acid CC chemokine originally cloned from LPS-stimulated rat lung. MIP-2 is induced during acute inflammation in rat models of diseases. It is a potent neutrophil chemotactic factor both in… More details

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Product Overview

Product Name
MIP-2, Polyclonal Antibody
Full Product Name
MIP-2 Antibody
Product Gene Name
anti-MIP-2 antibody
Product Synonym Names
MIP-2; MIP2; MIP 2; macrophge inhibitory protein-2; macrophge inhibitory protein 2; macrophge inhibitory protein
Clonality
Polyclonal
Isotype
IgG
Host
Rabbit
Species Reactivity
Mouse, Rat
Form/Format
100 ug (0.5 mg/ml) protein A purified rabbit anti-rat MIP-2 polyclonal antibody in phosphate buffered saline (PBS), pH 7.2, containing 50% glycerol, 1% BSA, 0.02% thimerosal.
Appearance: Colorless liquid
Purity/Purification
Affinity purified
Concentration
0.5 mg/ml (lot specific)
Preparation and Storage
At -20 degree C
Shelf Life: 12 months
Molecular Weight
10,783 Da
3D Structure
ModBase 3D Structure for P30348
Immunogen
E. coli-expressed mature rat MIP-2 (a.a. 1-69)
Handling
The antibody solution should be gently mixed before use.
Applications Tested/Suitable for anti-MIP-2 antibody
Western Blot (WB), Neutralization, ELISA (EIA)
Application Notes for anti-MIP-2 antibody
Western blot analysis (0.5-4 ug/ml), immunoprecipitation (4-8 ug/ml), and neutralization. However, the optimal conditions should be determined individually.

Other Notes

Small volumes of anti-MIP-2 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for MIP-2 purchase

MBS840551 is an antibody targeting MIP-2. Also known as MIP-2 Antibody. Reactive in Mouse, Rat. Host: Rabbit.

Additional Details

NCBI/Uniprot data below describe general gene information for MIP-2. It may not necessarily be applicable to this product.

NCBI GI #
16758460
NCBI GeneID
114105
NCBI Accession #
NP_446099.1
UniProt Primary Accession #
P30348
UniProt Secondary Accession #
Q5WA60
UniProt Related Accession #
P30348
GenBank Nucleotide #
NM_053647.1
NCBI Official Full Name
C-X-C motif chemokine 2
NCBI Official Synonym Full Names
chemokine (C-X-C motif) ligand 2
NCBI Official Symbol
Cxcl2
NCBI Official Synonym Symbols
Mip-2; Scyb2
UniProt Protein Name
C-X-C motif chemokine 2
UniProt Synonym Protein Names
Cytokine-induced neutrophil chemoattractant 3; CINC-3; Macrophage inflammatory protein 2; MIP2
Protein Family
Mitochondrial intermediate peptidase
UniProt Gene Name
Cxcl2
UniProt Synonym Gene Names
Cinc3; Mip-2; Mip2; Scyb2; CINC-3; MIP2
UniProt Entry Name
CXCL2_RAT
NCBI Protein Information
C-X-C motif chemokine 2

NCBI Summary for MIP-2

chemokine involved in the pulmonary inflammatory response [RGD, Feb 2006]

UniProt Comments for MIP-2

CXCL3: Ligand for CXCR2. Has chemotactic activity for neutrophils. May play a role in inflammation and exert its effects on endothelial cells in an autocrine fashion. In vitro, the processed form GRO-gamma(5-73) shows a fivefold higher chemotactic activity for neutrophilic granulocytes. Belongs to the intercrine alpha (chemokine CxC) family.

Protein type: Secreted; Secreted, signal peptide; Motility/polarity/chemotaxis

Cellular Component: extracellular space

Molecular Function: chemokine activity; CXCR chemokine receptor binding

Biological Process: neutrophil chemotaxis; wound healing; leukocyte chemotaxis; response to amphetamine; response to glucocorticoid stimulus; positive regulation of leukocyte chemotaxis; response to estradiol stimulus; regulation of cell proliferation; G-protein coupled receptor protein signaling pathway; elevation of cytosolic calcium ion concentration; response to heat; response to molecule of bacterial origin; response to gamma radiation; immune response; inflammatory response
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Research Articles on MIP-2

1. IL-1beta-mediated regulation of the CXCL1 and CXCL2 genes in pancreatic beta-cells requires stimulus-induced changes in histone chemical modifications, recruitment of the NF-kappaB and STAT1 transcription factors to genomic regulatory sequences within the proximal gene promoters, and increases in phosphorylated forms of RNA polymerase II.
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Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Products associated with anti-MIP-2 antibody

 Reference Product  PubMed Publications
 Cxcr2 antibody  >161 publications with MIP-2 and Cxcr2
 Cxcl10 antibody  >116 publications with MIP-2 and Cxcl10
 Cxcl5 antibody  >105 publications with MIP-2 and Cxcl5
 Ccl20 antibody  >81 publications with MIP-2 and Ccl20
 Cxcl12 antibody  >54 publications with MIP-2 and Cxcl12
 Ccr1 antibody  >27 publications with MIP-2 and Ccr1
 Cxcr1 antibody  >27 publications with MIP-2 and Cxcr1
 Cxcl11 antibody  >23 publications with MIP-2 and Cxcl11
 Cxcr3 antibody  >18 publications with MIP-2 and Cxcr3

Pathways associated with anti-MIP-2 antibody

 Products by Pathway  Pathway Diagram
 Chemokine Receptors Bind Chemokines Pathway antibodies  Chemokine Receptors Bind Chemokines Pathway Diagram
 Chemokine Signaling Pathway antibodies  Chemokine Signaling Pathway Diagram
 Chemokine Signaling Pathway antibodies  Chemokine Signaling Pathway Diagram
 Class A/1 (Rhodopsin-like Receptors) Pathway antibodies  Class A/1 (Rhodopsin-like Receptors) Pathway Diagram
 Cytokine-cytokine Receptor Interaction Pathway antibodies  Cytokine-cytokine Receptor Interaction Pathway Diagram
 Cytokine-cytokine Receptor Interaction Pathway antibodies  Cytokine-cytokine Receptor Interaction Pathway Diagram
 G Alpha (i) Signalling Events Pathway antibodies  G Alpha (i) Signalling Events Pathway Diagram
 GPCR Downstream Signaling Pathway antibodies  GPCR Downstream Signaling Pathway Diagram
 GPCR Ligand Binding Pathway antibodies  GPCR Ligand Binding Pathway Diagram
 Legionellosis Pathway antibodies  Legionellosis Pathway Diagram

Diseases associated with anti-MIP-2 antibody

 Disease Name  Pubmed Publications
 Inflammation Antibodies  >1076 publications with MIP-2 and Inflammation
 Necrosis Antibodies  >674 publications with MIP-2 and Necrosis
 Lung Diseases Antibodies  >410 publications with MIP-2 and Lung Diseases
 Disease Models, Animal Antibodies  >382 publications with MIP-2 and Disease Models, Animal
 Lung Injury Antibodies  >277 publications with MIP-2 and Lung Injury
 Pneumonia Antibodies  >178 publications with MIP-2 and Pneumonia
 Reperfusion Injury Antibodies  >117 publications with MIP-2 and Reperfusion Injury
 Edema Antibodies  >102 publications with MIP-2 and Edema
 Wounds and Injuries Antibodies  >100 publications with MIP-2 and Wounds and Injuries
 Skin Diseases Antibodies  >88 publications with MIP-2 and Skin Diseases

Organs/Tissues associated with anti-MIP-2 antibody

 Organ/Tissue Name  Pubmed Publications
 Lung Antibodies  >663 publications with MIP-2 and Lung
 Connective Tissue Antibodies  >29 publications with MIP-2 and Connective Tissue
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