ETK/BMX Antibody – Rabbit Polyclonal

This gene encodes a non-receptor tyrosine kinase belonging to the Tec kinase family. The protein contains a PH-like domain, which mediates membrane targeting by binding to phosphatidylinositol 3,4,5-triphosphate (PIP3), and a SH2 domain that binds to tyrosine-phosphorylated proteins and functions in signal transduction. The protein is implicated in several signal transduction pathways including the Stat pathway, and regulates differentiation and tumorigenicity of several types of cancer cells. Multiple alternatively spliced variants, encoding the same protein, have been identified.[provided by RefSeq, Sep 2009]

Etk: a tyrosine kinase of the Tec family. Activity is required for IL6-induced differentiation. May play a role in the growth and differentiation of hematopoietic cells. May be involved in signal transduction in endocardial and arterial endothelial cells.

Protein type: EC 2.7.10.2; Kinase, protein; Protein kinase, TK; Protein kinase, tyrosine (non-receptor); TK group; Tec family

Chromosomal Location of Human Ortholog: Xp22.2

Cellular Component: extrinsic to internal side of plasma membrane; cytosol

Molecular Function: protein binding; signal transducer activity; protein-tyrosine kinase activity; metal ion binding; non-membrane spanning protein tyrosine kinase activity; ATP binding; receptor binding

Biological Process: adaptive immune response; apoptosis; protein amino acid autophosphorylation; signal transduction; protein amino acid phosphorylation; T cell receptor signaling pathway; regulation of cell proliferation; B cell receptor signaling pathway; innate immune response; mesoderm development; cell adhesion; cell differentiation; transmembrane receptor protein tyrosine kinase signaling pathway; cell structure disassembly during apoptosis