MMP-3 Antibody – Rabbit Polyclonal

MMP3: Can degrade fibronectin, laminin, gelatins of type I, III, IV, and V; collagens III, IV, X, and IX, and cartilage proteoglycans. Activates procollagenase. Defects in MMP3 are the cause of susceptibility to coronary heart disease type 6 (CHDS6). A multifactorial disease characterized by an imbalance between myocardial functional requirements and the capacity of the coronary vessels to supply sufficient blood flow. Decreased capacity of the coronary vessels is often associated with thickening and loss of elasticity of the coronary arteries. A polymorphism in the MMP3 promoter region is associated with the risk of coronary heart disease and myocardial infarction, due to lower MMP3 proteolytic activity and higher extracellular matrix deposition in atherosclerotic lesions. Belongs to the peptidase M10A family.

Protein type: Protease; Secreted, signal peptide; EC 3.4.24.17; Secreted; Motility/polarity/chemotaxis

Cellular Component: extracellular matrix; extracellular space; proteinaceous extracellular matrix; protein complex; dendrite; nucleus

Molecular Function: zinc ion binding; metalloendopeptidase activity; endopeptidase activity; protein complex binding; calcium ion binding

Biological Process: positive regulation of protein oligomerization; collagen catabolic process; wound healing; response to cytokine stimulus; response to hypoxia; response to lipopolysaccharide; female pregnancy; response to amino acid stimulus; proteolysis; regulation of cell migration; response to estradiol stimulus; positive regulation of cell migration