TEM-8/ATR1 Antibody – Rabbit Polyclonal

ANTXR1: Plays a role in cell attachment and migration. Interacts with extracellular matrix proteins and with the actin cytoskeleton. Mediates adhesion of cells to type 1 collagen and gelatin, reorganization of the actin cytoskeleton and promotes cell spreading. Plays a role in the angiogenic response of cultured umbilical vein endothelial cells. Defects in ANTXR1 are associated with susceptibility to hemangioma capillary infantile (HCI). HCI are benign, highly proliferative lesions involving aberrant localized growth of capillary endothelium. They are the most common tumor of infancy, occurring in up to 10% of all births. Hemangiomas tend to appear shortly after birth and show rapid neonatal growth for up to 12 months characterized by endothelial hypercellularity and increased numbers of mast cells. This phase is followed by slow involution at a rate of about 10% per year and replacement by fibrofatty stroma. Belongs to the ATR family. 4 isoforms of the human protein are produced by alternative splicing.

Protein type: Actin-binding; Membrane protein, integral; Receptor, misc.

Cellular Component: filopodium membrane; cell surface; cell projection; membrane; integral to membrane; plasma membrane

Molecular Function: actin filament binding; collagen binding; transmembrane receptor activity; metal ion binding; receptor activity

Biological Process: actin cytoskeleton reorganization; reproductive process; signal transduction