NHERF1/EBP50 Antibody – Rabbit Polyclonal

NHERF: a scaffold protein that connects plasma membrane proteins with members of the Ezrin/moesin/radixin family and thereby helps to link them to the actin cytoskeleton and to regulate their surface expression. Necessary for recycling of internalized beta-2-adrenergic receptor Was first known to play a role in the regulation of the activity and subcellular location of SLC9A3. Necessary for cAMP-mediated phosphorylation and inhibition of SLC9A3. May enhance Wnt signaling.

Protein type: Motility/polarity/chemotaxis; Adaptor/scaffold

Cellular Component: centrosome; microvillus; intracellular membrane-bound organelle; brush border membrane; cell; endomembrane system; stereocilium bundle tip; lipid raft; ruffle; stereocilium; membrane; apical part of cell; microvillus membrane; cytoplasm; apical plasma membrane; plasma membrane; intracellular; nucleus; vesicle; filopodium

Molecular Function: protein domain specific binding; protein binding; chloride channel regulator activity; protein self-association; beta-2 adrenergic receptor binding; protein complex binding; beta-catenin binding; dopamine receptor binding; protein complex scaffold; receptor binding; phosphatase binding; PDZ domain binding

Biological Process: bile acid secretion; Wnt receptor signaling pathway; negative regulation of protein kinase B signaling cascade; renal sodium ion transport; negative regulation of cell proliferation; microvillus biogenesis; cAMP-mediated signaling; cellular phosphate ion homeostasis; sensory perception of sound; auditory receptor cell stereocilium organization and biogenesis; dopamine receptor, phospholipase C activating pathway; negative regulation of sodium:hydrogen antiporter activity; regulation of protein kinase activity; actin cytoskeleton organization and biogenesis; negative regulation of cell migration; dopamine receptor, adenylate cyclase activating pathway; negative regulation of phosphoinositide 3-kinase cascade