PDK1 Antibody – Rabbit Polyclonal

PDK1: an AGC kinase of the PKB family that contains a PH domain. Involved in a wide variety of processes including cell proliferation, differentiation and apoptosis. Autophosphorylation in the activation loop is necessary for activity. Phosphorylates and activates kinases including Akt, PKC isozymes, p70 S6K and RSK. Three alternatively-spliced isoforms have been described.

Protein type: Protein kinase, Ser/Thr (non-receptor); EC 2.7.11.1; Nuclear receptor co-regulator; Kinase, protein; Protein kinase, AGC; AGC group; PKB family

Cellular Component: cell projection; membrane; cytoplasmic membrane-bound vesicle; cytoplasm; plasma membrane; nucleus; cell junction; cytosol

Molecular Function: transferase activity; protein serine/threonine kinase activity; protein binding; phospholipase binding; 3-phosphoinositide-dependent protein kinase activity; transferase activity, transferring phosphorus-containing groups; nucleotide binding; kinase activity; protein kinase binding; ATP binding; insulin receptor binding; phospholipase activator activity; protein kinase activity

Biological Process: regulation of mast cell degranulation; epidermal growth factor receptor signaling pathway; focal adhesion formation; cell migration; transcription, DNA-dependent; activation of protein kinase B; calcium-mediated signaling; peptidyl-threonine phosphorylation; signal transduction; protein amino acid phosphorylation; hyperosmotic response; cellular response to insulin stimulus; regulation of transcription, DNA-dependent; negative regulation of toll-like receptor signaling pathway; negative regulation of protein kinase activity; positive regulation of release of sequestered calcium ion into cytosol; negative regulation of transforming growth factor beta receptor signaling pathway; regulation of I-kappaB kinase/NF-kappaB cascade; phosphorylation