Rabbit Anti-FKBP38 Polyclonal Antibody – Cat# MBS840677

FKBP38 Antibody – Rabbit Polyclonal

Name: FKBP38 Antibody; Polyclonal; Rabbit; Human/Mouse/Rat-Reactive; MyBioSource
Brand: MyBioSource
SKU: MBS840677
Price: 215 USD
Availability: InStock
Rating: 5 (10 reviews)

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS840677

Background: FK506-binding protein 38 (FKBP38), a member of the immunophilin family, has been implicated to play an important role in apoptosis thromugh its involvement in the mechanism that targets Bcl-2 and Bcl-xL to the outer mitochondrial membrane (OMM).… More details

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Product Documentation

Sample Manual Insert View PDF

Testing Data View PDF

Certificate of Analysis (COA) View PDF

QC Report View PDF

Material Safety Data Sheet View PDF

Technical Datasheet View PDF

Protocol View PDF

Product Overview

Product Name

FKBP38, Polyclonal Antibody

Full Product Name

FKBP38 Antibody

Product Gene Name

anti-FKBP38 antibody

Product Synonym Names

FKBPR38; FKBP8; FKBP 8; FK506 binding protein 8; FKBP 38

Clonality

Polyclonal

Isotype

IgG

Host

Rabbit

Species Reactivity

Human, Mouse, Rat

Form/Format

100 ug (0.2mg/ml) protein A purified rabbit anti-FKBP38 polyclonal antibody in phosphate-buffered saline (PBS) containing 0.1% BSA, 20% glycerol, and 0.02% thimerosal.
Appearance: Colorless liquid

Purity/Purification

Affinity purified

Concentration

0.2 mg/ml (lot specific)

Preparation and Storage

At -20 degree C
Shelf Life: 12 months

Molecular Weight

43,616 Da

Immunogen

Synthetic peptide surrounding amino acid 344 of mouse FKBP38

Handling

The antibody solution should be gently mixed before use.

Applications Tested/Suitable for anti-FKBP38 antibody

Western Blot (WB)

Application Notes for anti-FKBP38 antibody

Western blotting (0.5-4 ug/ml). However, the optimal concentrations should be determined individually. Blocking peptide is available separately. The antibody recognizes a ~40 kDa band in samples from human, mouse and rat origins. Reactivity to other species has not been tested.

Other Notes

Small volumes of anti-FKBP38 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for FKBP38 purchase

MBS840677 is an antibody targeting FKBP38. Also known as FKBP38 Antibody. Reactive in Human, Mouse, Rat. Host: Rabbit.

Additional Details

NCBI/Uniprot data below describe general gene information for FKBP38. It may not necessarily be applicable to this product.

NCBI GI #

28395544

NCBI Accession #

AY225340

UniProt Secondary Accession #

Q3UK86; Q6GTX9; Q811M7; Q811R4; Q8C2F0; Q99L93

NCBI Official Full Name

Mus musculus FK506-binding protein 38 mRNA, complete cds

UniProt Protein Name

Peptidyl-prolyl cis-trans isomerase FKBP8

UniProt Synonym Protein Names

38 kDa FK506-binding protein; 38 kDa FKBP; FKBP-38; mFKBP38; FK506-binding protein 8; FKBP-8; FKBPR38; Rotamase

UniProt Gene Name

Fkbp8

UniProt Synonym Gene Names

Fkbp38; Sam11; PPIase FKBP8; 38 kDa FKBP; FKBP-38; mFKBP38; FKBP-8

UniProt Entry Name

FKBP8_MOUSE

UniProt Comments for FKBP38

FKBP8: Constitutively inactive PPiase, which becomes active when bound to calmodulin and calcium. Seems to act as a chaperone for BCL2, targets it to the mitochondria and modulates its phosphorylation state. The BCL2/FKBP8/calmodulin/calcium complex probably interferes with the binding of BCL2 to its targets. The active form of FKBP8 may therefore play a role in the regulation of apoptosis. 2 isoforms of the human protein are produced by alternative splicing.

Protein type: Membrane protein, integral; Chaperone; Isomerase; EC 5.2.1.8; Mitochondrial

Cellular Component: mitochondrial envelope; mitochondrion; membrane; integral to membrane; integral to endoplasmic reticulum membrane

Molecular Function: identical protein binding; peptidyl-prolyl cis-trans isomerase activity; FK506 binding; isomerase activity

Biological Process: neural tube development; smoothened signaling pathway; camera-type eye development; protein peptidyl-prolyl isomerization; protein folding; apoptosis; multicellular organism growth; regulation of BMP signaling pathway; cell fate specification; dorsal/ventral pattern formation; regulation of gene expression; dorsoventral neural tube patterning; positive regulation of BMP signaling pathway; negative regulation of apoptosis

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.