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NP-1 Antibody – Goat Polyclonal

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS840681

Background: Human alpha-defensin-1 (NP-1) is an antimicrobial peptide which belongs to the distinct family of alpha-defensins. Human NP-1 is a 3.4 kDa protein containing 30 amino acid residues. More details

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Testing Data View PDF
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Material Safety Data Sheet View PDF
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Technical Datasheet View PDF
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Protocol View PDF

Product Overview

Product Name
NP-1, Polyclonal Antibody
Full Product Name
NP-1 Antibody
Product Gene Name
Product Synonym Names
NP1; NP 1; NP-1; alpha-defensin-1; alpha defensin1; alpha defensin 1; alpha defensin
Clonality
Polyclonal
Isotype
IgG
Host
Goat
Species Reactivity
Human
Form/Format
100 ug (0.5 mg/ml) antigen affinity purified goat anti-human NP-1 polyclonal antibody in phosphate buffered saline (PBS), pH 7.2, containing 50% glycerol, and 0.02% thimerosal.
Appearance: Colorless liquid
Purity/Purification
Affinity purified
Concentration
0.5 mg/ml (lot specific)
Preparation and Storage
At -20 degree C
Shelf Life: 12 months
Molecular Weight
10,201 Da
OMIM
125220
Immunogen
E. coli expressed human NP-1
Handling
The antibody solution should be gently mixed before use.
Applications Tested/Suitable for anti-NP-1 antibody
Western Blot (WB), ELISA (EIA)
Application Notes for anti-NP-1 antibody
Western blot analysis (0.5-1 ug/ml) and ELISA (2-4 ug/ml). However, the optimal conditions should be determined individually.

Other Notes

Small volumes of anti-NP-1 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for NP-1 purchase

MBS840681 is an antibody targeting NP-1. Also known as NP-1 Antibody. Reactive in Human. Host: Goat.

Additional Details

NCBI/Uniprot data below describe general gene information for NP-1. It may not necessarily be applicable to this product.

NCBI GI #
NCBI GeneID
NCBI Accession #
UniProt Secondary Accession #
UniProt Related Accession #
GenBank Nucleotide #
NCBI Official Full Name
neutrophil defensin 1 preproprotein
NCBI Official Synonym Full Names
defensin, alpha 1
NCBI Official Symbol
DEFA1
NCBI Official Synonym Symbols
HP1; MRS; DEF1; HP-1; DEFA2; HNP-1
UniProt Protein Name
Neutrophil defensin 1
UniProt Synonym Protein Names
Defensin, alpha 1; HNP-1; HP-1; HP1
UniProt Gene Name
DEFA1
UniProt Synonym Gene Names
DEF1; DEFA2; MRS; HP-1; HP1; HP-2; HP2
UniProt Entry Name
DEF1_HUMAN
NCBI Protein Information
neutrophil defensin 1

NCBI Summary for NP-1

Defensins are a family of antimicrobial and cytotoxic peptides thought to be involved in host defense. They are abundant in the granules of neutrophils and also found in the epithelia of mucosal surfaces such as those of the intestine, respiratory tract, urinary tract, and vagina. Members of the defensin family are highly similar in protein sequence and distinguished by a conserved cysteine motif. The protein encoded by this gene, defensin, alpha 1, is found in the microbicidal granules of neutrophils and likely plays a role in phagocyte-mediated host defense. Several alpha defensin genes are clustered on chromosome 8. This gene differs from defensin, alpha 3 by only one amino acid. This gene and the gene encoding defensin, alpha 3 are both subject to copy number variation. [provided by RefSeq, Oct 2014]
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UniProt Comments for NP-1

defensin, alpha 1: Defensin 1 and defensin 2 have antibacterial, fungicide and antiviral activities. Has antimicrobial activity against Gram- negative and Gram-positive bacteria. Defensins are thought to kill microbes by permeabilizing their plasma membrane. Belongs to the alpha-defensin family.

Protein type: Secreted; Secreted, signal peptide

Chromosomal Location of Human Ortholog: 8p23.1

Cellular Component: extracellular matrix; extracellular space; Golgi lumen; extracellular region

Biological Process: defense response to Gram-positive bacterium; estrogen receptor signaling pathway; innate immune response in mucosa; killing of cells of another organism; antibacterial humoral response; innate immune response; immune response; chemotaxis; defense response to virus; defense response to fungus
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Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

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