TrkB Antibody – Rabbit Polyclonal

TrkB: a receptor tyrosine kinase of the Trk family. Receptor for brain-derived neurotrophic factor (BDNF), neurotrophin-3, -4 and -5 but not nerve growth factor (NGF). Involved in the development and maintenance of the nervous system. Three splice variant isoforms have been described.

Protein type: Protein kinase, TK; Kinase, protein; EC 2.7.10.1; Membrane protein, integral; Protein kinase, tyrosine (receptor); TK group; Trk family

Cellular Component: cell surface; rough endoplasmic reticulum; integral to plasma membrane; cell; dendrite; postsynaptic density; dendritic spine; excitatory synapse; terminal button; perikaryon; cytosol; Golgi membrane; postsynaptic membrane; growth cone; cell soma; axon; cytoplasm; presynaptic active zone; plasma membrane; endosome membrane; intracellular; nerve terminal; endosome; receptor complex

Molecular Function: brain-derived neurotrophic factor receptor activity; neurotrophin binding; protein binding; protein homodimerization activity; ephrin receptor binding; brain-derived neurotrophic factor binding; transmembrane receptor protein tyrosine kinase activity; neurotrophin receptor activity; ATP binding

Biological Process: circadian rhythm; mechanoreceptor differentiation; retinal rod cell development; peptidyl-tyrosine phosphorylation; protein amino acid autophosphorylation; neuron migration; regulation of neurotransmitter secretion; regulation of dendrite development; positive regulation of synaptic transmission, glutamatergic; neuron differentiation; positive regulation of MAPKKK cascade; positive regulation of cell proliferation; oligodendrocyte differentiation; feeding behavior; negative regulation of neuron apoptosis; regulation of metabolic process; inflammatory response; vasculogenesis; neuromuscular junction development; central nervous system neuron development; aging; response to light stimulus; brain-derived neurotrophic factor receptor signaling pathway; regulation of protein kinase B signaling cascade; learning; positive regulation of peptidyl-serine phosphorylation; positive regulation of phosphoinositide 3-kinase cascade; peripheral nervous system neuron development; long-term memory; glutamate secretion; regulation of MAPKKK cascade; positive regulation of axonogenesis; cerebral cortex development