Survivin (BIRC5) Antibody – Rabbit Polyclonal

This gene is a member of the inhibitor of apoptosis (IAP) gene family, which encode negative regulatory proteins that prevent apoptotic cell death. IAP family members usually contain multiple baculovirus IAP repeat (BIR) domains, but this gene encodes proteins with only a single BIR domain. The encoded proteins also lack a C-terminus RING finger domain. In humans, gene expression is high during fetal development and in most tumors yet low in adult tissues. Antisense transcripts have been identified in human that regulate this gene's expression. At least three transcript variants encoding distinct isoforms have been found for this gene, although at least one of these transcript variants is a nonsense-mediated decay (NMD) candidate. [provided by RefSeq, Jul 2008]

Survivin: an apoptosis inhibitor that is expressed during the G2/M phase of the cell cycle. Associates with the microtubules of the mitotic spindle and any disruption results in the loss of apoptosis activity. May play a role in neoplasia. Inhibitor of caspase-3 and caspase-7. Two splice variant isoforms have been described.

Protein type: Apoptosis

Cellular Component: nuclear chromosome; microtubule; chromosome; cytosol; interphase microtubule organizing center; centriole; kinetochore; cytoskeleton; cytoplasmic microtubule; spindle microtubule; cytoplasm; apical plasma membrane; midbody; nucleus; chromosome, pericentric region

Molecular Function: tubulin binding; identical protein binding; protein homodimerization activity; zinc ion binding; protease inhibitor activity; metal ion binding; microtubule binding; caspase inhibitor activity; ubiquitin-protein ligase activity; protein binding; enzyme binding; protein heterodimerization activity; chaperone binding; cofactor binding; cysteine protease inhibitor activity; Ran GTPase binding

Biological Process: apoptosis; regulation of mitotic cell cycle; regulation of signal transduction; negative regulation of peptidase activity; cytokinesis; protein ubiquitination; negative regulation of caspase activity; positive regulation of mitotic cell cycle; protein amino acid phosphorylation; chromosome segregation; regulation of transcription, DNA-dependent; negative regulation of neuron apoptosis; G2/M transition of mitotic cell cycle; positive regulation of exit from mitosis; mitosis; spindle checkpoint; transcription, DNA-dependent; establishment of chromosome localization; positive regulation of cell cycle; microtubule cytoskeleton organization and biogenesis; cell cycle; embryonic development; protein complex localization; cell division; negative regulation of transcription, DNA-dependent; negative regulation of apoptosis