Lamin B1 (LMNB1) Antibody – Rabbit Polyclonal

Lamin B1: nuclear lamins are intermediate filament proteins that constitute the lattice-like matrix at the inner face of the nuclear membrane that underlies the nuclear envelop. The lamins, highly conserved throughout evolution, are encoded by three genes in the human: LMNA, LMNB1, and LMNB2. The A-type lamins (lamin A/C) are developmentally regulated and are generally expressed in differentiated cells. The anchoring of chromatin to the nuclear lamina is involved in the control of gene expression and in DNA replication and repair. During mitosis, the nuclear lamina is reversibly disassembled as the lamin proteins are phosphorylated. B-type lamins are phosphorylated within minutes of engaging the IgM surface receptor of resting splenic B cells. Nuclear lamins are cleaved by caspases during apoptosis.

Protein type: Cytoskeletal

Cellular Component: nucleoplasm; nuclear membrane; nuclear matrix; membrane; lamin filament; intermediate filament; nuclear inner membrane; nuclear envelope; nucleus

Molecular Function: JUN kinase binding; phospholipase binding; structural molecule activity

Biological Process: G2/M-specific positive regulation of cyclin-dependent protein kinase activity; positive regulation of JNK cascade