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KCNK2 Antibody – Rabbit Polyclonal

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS9612001

Function: Ion channel that contributes to passive transmembrane potassium transport (PubMed:23169818). Reversibly converts between a voltage-insensitive potassium leak channel and a voltage-dependent outward rectifying potassium channel in a… More details

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Product Overview

Online Datasheet in PDF
Product Name
KCNK2, Polyclonal Antibody
Full Product Name
KCNK2 Antibody
Product Gene Name
anti-KCNK2 antibody
Product Synonym Gene Name
TREK, TREK1
Product Synonym Names
hTREK 1c; hTREK 1e; K2p2.1; K2P2.1 potassium channel; KCNK 2; Kcnk2; KCNK2_HUMAN; MGC126742; MGC126744; Outward rectifying potassium channel protein TREK 1; Outward rectifying potassium channel protein TREK-1; Outward rectifying potassium channel protein TREK1; Potassium channel subfamily K member 2; Potassium inwardly rectifying channel subfamily K member 2; Tandem pore domain potassium channel TREK 1; Tandem pore domain potassium channel TREK1; TPKC1; TREK 1; TREK 1 K(+) channel subunit; TREK; TREK-1 K(+) channel subunit; TREK1; TWIK related potassium channel 1; Two pore domain potassium channel TREK 1; Two pore domain potassium channel TREK-1; Two pore domain potassium channel TREK1; Two pore potassium channel 1; Two pore potassium channel TPKC1
Clonality
Polyclonal
Isotype
IgG
Host
Rabbit
Species Reactivity
Human, Mouse, Rat
Form/Format
Rabbit IgG in phosphate buffered saline, pH7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol
Purity/Purification
Peptide affinity purification
Concentration
1mg/ml (lot specific)
Specificity
KCNK2 Antibody detects endogenous levels of total KCNK2.
Preparation and Storage
Store at -20°C. Stable for up to 12 months from date of receipt.
Antibody/Peptide Pairs
KCNK2 peptide (MBS9621945) is used for blocking the activity of KCNK2 antibody (MBS9612001)
Molecular Weight
47 kDa
OMIM
AF129399 mRNA
3D Structure
ModBase 3D Structure for O95069
Supply Chain Verification
Manufactured in a lab with traceable raw materials manufactured on site. Coordinated product portfolio of antibodies, pairs, conjugates, recombinant proteins, and immunoassay materials available, please inquire.
Immunogen
A synthesized peptide derived from human KCNK2, corresponding to a region within N-terminal amino acids.
Fragment
Fab fragment
ISO Certification
Manufactured in an ISO 9001:2015 Certified Laboratory.
Applications Tested/Suitable for anti-KCNK2 antibody
ELISA (EIA)
Application Notes for anti-KCNK2 antibody
WB: 1:500-1:2000
IHC: 1:50-1:200
ELISA(peptide): 1:20,000-1:40,000
*The optimal dilutions should be determined by the end user.

IMPORTANT: For western blot, incubate membrane with diluted primary Abin 5% w/v milk , 1X TBS, 0.1% Tween®20 at 4°C with gentle shaking,overnight.

Western Blot (WB) of anti-KCNK2 antibody

Western blot analysis of extracts from Human brain, using KCNK2 Antibody. The lane on the left was treated with blocking peptide.
Rabbit Anti-KCNK2 Polyclonal Antibody – Cat# MBS9612001

Immunohistochemistry (IHC)-Paraffin of anti-KCNK2 antibody

MBS9612001 at 1/100 staining Mouse kidney tissue by IHC-P. The sample was formaldehyde fixed and a heat mediated antigen retrieval step in citrate buffer was performed. The sample was then blocked and incubated with the primary antibody at 4°C overnight. An HRP conjugated anti-Rabbit antibody was used as the secondary antibody.
Rabbit Anti-KCNK2 Polyclonal Antibody, Immunohistochemistry (IHC)-Paraffin – Cat# MBS9612001

Other Notes

Small volumes of anti-KCNK2 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for KCNK2 purchase

MBS9612001 is an antibody targeting KCNK2. Also known as KCNK2 Antibody. Reactive in Human, Mouse, Rat. Host: Rabbit.

Additional Details

NCBI/Uniprot data below describe general gene information for KCNK2. It may not necessarily be applicable to this product.

NCBI GI #
62912487
NCBI GeneID
3776
NCBI Accession #
NP_001017424.1
UniProt Primary Accession #
O95069
UniProt Related Accession #
O95069
GenBank Nucleotide #
NP_001017424.1
NCBI Official Full Name
potassium channel subfamily K member 2 isoform a
NCBI Official Synonym Full Names
potassium two pore domain channel subfamily K member 2
NCBI Official Symbol
KCNK2
NCBI Official Synonym Symbols
TREK; TPKC1; TREK1; K2p2.1; TREK-1; hTREK-1c; hTREK-1e
UniProt Protein Name
Potassium channel subfamily K member 2
UniProt Synonym Protein Names
Outward rectifying potassium channel protein TREK-1; TREK-1 K(+) channel subunit; Two pore domain potassium channel TREK-1; Two pore potassium channel TPKC1
Protein Family
Potassium channel subfamily
UniProt Gene Name
KCNK2
UniProt Synonym Gene Names
TREK; TREK1
NCBI Protein Information
potassium channel subfamily K member 2

NCBI Summary for KCNK2

This gene encodes one of the members of the two-pore-domain background potassium channel protein family. This type of potassium channel is formed by two homodimers that create a channel that leaks potassium out of the cell to control resting membrane potential. The channel can be opened, however, by certain anesthetics, membrane stretching, intracellular acidosis, and heat. Three transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]
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UniProt Comments for KCNK2

Ion channel that contributes to passive transmembrane potassium transport (PubMed:23169818). Reversibly converts between a voltage-insensitive potassium leak channel and a voltage-dependent outward rectifying potassium channel in a phosphorylation-dependent manner (PubMed:11319556). In astrocytes, forms mostly heterodimeric potassium channels with KCNK1, with only a minor proportion of functional channels containing homodimeric KCNK2. In astrocytes, the heterodimer formed by KCNK1 and KCNK2 is required for rapid glutamate release in response to activation of G-protein coupled receptors, such as F2R and CNR1 ().
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Research Articles on KCNK2

1. The activity of TREK-1 has a key role for the correct functioning of the alveolar epithelium.

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Products associated with anti-KCNK2 antibody

 Reference Product  PubMed Publications
 KCNK10 antibody  >11 publications with KCNK2 and KCNK10
 KCNK4 antibody  >7 publications with KCNK2 and KCNK4
 KCND2 antibody  >2 publications with KCNK2 and KCND2
 TRPM8 antibody  >1 publications with KCNK2 and TRPM8

Pathways associated with anti-KCNK2 antibody

 Products by Pathway  Pathway Diagram
 Cardiac Conduction Pathway antibodies  Cardiac Conduction Pathway Diagram
 Gastric Acid Secretion Pathway antibodies  Gastric Acid Secretion Pathway Diagram
 Gastric Acid Secretion Pathway antibodies  Gastric Acid Secretion Pathway Diagram
 Muscle Contraction Pathway antibodies  Muscle Contraction Pathway Diagram
 Neuronal System Pathway antibodies  Neuronal System Pathway Diagram
 Phase 4 - Resting Membrane Potential Pathway antibodies  Phase 4 - Resting Membrane Potential Pathway Diagram
 Potassium Channels Pathway antibodies  Potassium Channels Pathway Diagram
 TWIK Related Potassium Channel (TREK) Pathway antibodies  TWIK Related Potassium Channel (TREK) Pathway Diagram
 Tandem Pore Domain Potassium Channels Pathway antibodies  Tandem Pore Domain Potassium Channels Pathway Diagram

Diseases associated with anti-KCNK2 antibody

 Disease Name  Pubmed Publications
 Nervous System Diseases Antibodies  >9 publications with KCNK2 and Nervous System Diseases
 Depressive Disorder Antibodies  >6 publications with KCNK2 and Depressive Disorder
 Inflammation Antibodies  >4 publications with KCNK2 and Inflammation
 Cardiovascular Diseases Antibodies  >3 publications with KCNK2 and Cardiovascular Diseases
 Diabetes Mellitus Antibodies  >2 publications with KCNK2 and Diabetes Mellitus
 Heart Diseases Antibodies  >2 publications with KCNK2 and Heart Diseases
 Fibrosis Antibodies  >2 publications with KCNK2 and Fibrosis
 Seizures Antibodies  >1 publications with KCNK2 and Seizures
 Heart Failure Antibodies  >1 publications with KCNK2 and Heart Failure
 Hypertension Antibodies  >1 publications with KCNK2 and Hypertension

Organs/Tissues associated with anti-KCNK2 antibody

 Organ/Tissue Name  Pubmed Publications
 Brain Antibodies  >13 publications with KCNK2 and Brain
 Muscle Antibodies  >4 publications with KCNK2 and Muscle
 Adrenal Gland Antibodies  >4 publications with KCNK2 and Adrenal Gland
 Ovary Antibodies  >3 publications with KCNK2 and Ovary
 Lung Antibodies  >3 publications with KCNK2 and Lung
 Kidney Antibodies  >3 publications with KCNK2 and Kidney
 Testis Antibodies  >1 publications with KCNK2 and Testis
 Skin Antibodies  >1 publications with KCNK2 and Skin
 Thyroid Antibodies  >1 publications with KCNK2 and Thyroid
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