ILK1 Antibody – Rabbit Polyclonal

ILK: a tyrosine kinase-like kinase of the MLK family. Couples integrins and growth factors to downstream pathways involved in cell survival, cell cycle control, cell-cell adhesion and cell motility. Functions as a scaffold bridging the extra-cellular matrix and growth factor receptors to the actin cytoskeleton through interactions with the ILK-PINCH complex. This complex, which includes integrin, PINCH (which links ILK to receptor tyrosine kinases via Nck2), PARVA and affixin, is considered to be one of the convergence points of integrin- and growth factor-signaling pathways. May be implicated in mediating cell architecture, adhesion to integrin substrates and anchorage-dependent growth in epithelial cells. Stimulated downstream of PI3 kinase. Increased expression is correlated with progression of several tumor types, including breast, prostate, and colon carcinomas. Overexpression drives anchorage-independent growth and faster cell cycle.

Protein type: Protein kinase, TKL; EC 2.7.11.1; Kinase, protein; Protein kinase, Ser/Thr (non-receptor); TKL group; MLK family; ILK subfamily

Cellular Component: protein complex; focal adhesion; costamere; terminal button; intercellular junction; nucleoplasm; extracellular matrix; cell projection; cell soma; membrane; lamellipodium; axon; cytoplasm; stress fiber; plasma membrane; dendritic shaft; intracellular; cell junction

Molecular Function: integrin binding; transferase activity; protein serine/threonine kinase activity; protein binding; signal transducer activity; transferase activity, transferring phosphorus-containing groups; nucleotide binding; kinase activity; SH3 domain binding; protein kinase binding; ATP binding; protein kinase activity

Biological Process: Schwann cell development; negative regulation of smooth muscle cell proliferation; protein heterooligomerization; positive regulation of axon extension; positive regulation of transcription, DNA-dependent; regulation of signal transduction; negative regulation of smooth muscle cell migration; protein amino acid phosphorylation; positive regulation of MAP kinase activity; myelin formation; positive regulation of MAPKKK cascade; cell projection organization and biogenesis; positive regulation of cell proliferation; protein kinase B signaling cascade; fibril organization and biogenesis; regulation of cell growth; negative regulation of neuron apoptosis; cell cycle arrest; positive regulation of cell-matrix adhesion; positive regulation of BMP signaling pathway; integrin-mediated signaling pathway; cell aging; positive regulation of dendrite morphogenesis; positive regulation of myoblast differentiation; myelination in the peripheral nervous system; establishment and/or maintenance of epithelial cell polarity; positive regulation of osteoblast differentiation; positive regulation of protein kinase B signaling cascade; peptidyl-serine phosphorylation; ureteric bud branching; regulation of actin cytoskeleton organization and biogenesis; negative regulation of protein kinase activity; positive regulation of axonogenesis; nerve development; phosphorylation; neurite morphogenesis; positive regulation of phosphorylation; negative regulation of apoptosis; positive regulation of cell migration