FATP4 Antibody – Rabbit Polyclonal

SLC27A4: Involved in translocation of long-chain fatty acids (LFCA) across the plasma membrane. Appears to be the principal fatty acid transporter in small intestinal enterocytes. Plays a role in the formation of the epidermal barrier. Required for fat absorption in early embryogenesis. Has acyl-CoA ligase activity for long-chain and very-long-chain fatty acids. Defects in SLC27A4 are the cause of ichthyosis prematurity syndrome (IPS). A keratinization disorder characterized by complications in the second trimester of pregnancy resulting from polyhydramnion, with premature birth of a child with thick caseous desquamating epidermis, respiratory complications and transient eosinophilia. After recovery during the first months of life, the symptoms are relatively benign and the patients suffer from a lifelong non-scaly ichthyosis with atopic manifestations. Belongs to the ATP-dependent AMP-binding enzyme family.

Protein type: Transporter, SLC family; Membrane protein, multi-pass; EC 6.2.1.-; Ligase; Transporter; Membrane protein, integral

Cellular Component: endoplasmic reticulum membrane; microvillus; membrane; brush border membrane; endoplasmic reticulum; integral to membrane; plasma membrane

Molecular Function: very-long-chain-fatty-acid-CoA ligase activity; long-chain-fatty-acid-CoA ligase activity

Biological Process: long-chain fatty acid transport; skin development; very-long-chain fatty acid catabolic process; very-long-chain fatty acid metabolic process; long-chain fatty acid metabolic process; fatty acid metabolic process; medium-chain fatty acid transport; response to nutrient